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Histidine

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Identification
Molecular formula
C6H9N3O2
CAS number
71-00-1
IUPAC name
2-amino-3-(1H-imidazol-5-yl)propanoic acid
State
State

At room temperature, histidine is in solid state, typically in the form of a crystalline powder.

Melting point (Celsius)
287.00
Melting point (Kelvin)
560.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
155.16g/mol
Molar mass
155.1550g/mol
Density
1.4100g/cm3
Appearence

Histidine appears as white to off-white crystals or crystalline powder. It is typically odorless and has a slightly bitter taste. The compound is commonly used as a supplement and in biochemistry research.

Comment on solubility

Solubility of 2-amino-3-(1H-imidazol-5-yl)propanoic acid

2-amino-3-(1H-imidazol-5-yl)propanoic acid (C6H9N3O2), an amino acid derivative, exhibits interesting solubility characteristics.

Key Factors Affecting Solubility:

  • Polarity: The presence of both hydrophilic (amino and carboxylic groups) and hydrophobic (imidazole ring) moieties influences solubility in various solvents.
  • pH Levels: The protonation and deprotonation of the carboxylic acid group can significantly impact solubility, making it more soluble in acidic or neutral conditions.
  • Temperature: Increased temperatures can enhance solubility, as is common with many amino acids.

In general, 2-amino-3-(1H-imidazol-5-yl)propanoic acid is expected to be quite soluble in water due to its ionic and polar nature. The imidazole moiety can also facilitate interactions with aqueous environments, further enhancing solubility.

In conclusion, one can say that the dynamic interactions within different solvent systems, particularly water, make this compound readily soluble, which is essential for its biochemical activities. Its solubility profile not only denotes its reactivity but also its potential applications in various fields.

Interesting facts

Interesting Facts about 2-amino-3-(1H-imidazol-5-yl)propanoic acid

2-amino-3-(1H-imidazol-5-yl)propanoic acid, also known as histidine, is an essential amino acid that plays a crucial role in various biological processes. Here are some fascinating insights into this compound:

  • Biological Significance: Histidine is pivotal for the biosynthesis of proteins—serving as a building block for numerous enzymes and hormones within the body.
  • Buffering Agent: This amino acid possesses a side chain that can easily accept or donate protons, making it an effective buffering agent, particularly in the blood where it helps maintain pH balance.
  • Neurotransmitter Role: Histidine is integral in the synthesis of neurotransmitters such as histamine, which is pivotal in immune responses and acts as a neurotransmitter, impacting functions like gastric secretion and sleep-wake cycles.
  • Dietary Source: It can be obtained from dietary sources such as meat, fish, dairy products, and certain grains. Deficiency in histidine might lead to various health issues, including cognitive dysfunctions.
  • Histidine and Health: Studies suggest that supplementation with histidine may have potential benefits, including promoting muscle recovery and enhancing exercise performance.

In summary, 2-amino-3-(1H-imidazol-5-yl)propanoic acid is not just an ordinary amino acid; it is a remarkable compound with significant roles in metabolism, immune response, and neurotransmission. Its multifaceted properties and contributions to human health make it a topic of keen interest in both biochemical and clinical research.

Synonyms
DL-HISTIDINE
4998-57-6
H-DL-His-OH
2-amino-3-(1H-imidazol-4-yl)propanoic acid
2-amino-3-(1H-imidazol-5-yl)propanoic acid
D,L-histidine
Histidine, DL-
histidin
26062-48-6
MFCD00005208
184709-11-3
QU6SDF3Q03
POLY-L-HISTIDINE HYDROCHLORIDE MW
DL-2-Amino-3-(4-imidazolyl)propionsaeure
L-Histidine Base
(+/-)-2-Amino-3-(4-imidazolyl)propionic acid
UNII-QU6SDF3Q03
CHEBI:27570
NSC137773
Histidine #
EINECS 225-660-9
DL-His-OH
alpha-Amino-1H-imidazole-4-propionic acid
DL-Histidine, free base
His108
2-Amino-3-(1H-imidazol-4-yl)-propionic acid
SCHEMBL3258
(+/-)-HISTIDINE
1H-IMIDAZOLE-4-ALANINE
BDBM81938
DTXSID00901785
NSC_773
DL-Histidine, >=99% (TLC)
NSC620356
PDSP1_000116
PDSP2_000116
AKOS000269100
AKOS015906006
AKOS016037364
1H-Imidazole-4-propanoic acid, (S)-
CS-W010925
FD21675
FH47225
HY-W010209
NSC-620356
CAS_71-00-1
2-Amino-3-(4-imidazolyl)propionic acid
AS-13497
SY011122
SY034122
SY034142
D-2-Amino-3-(4-imidazolyl)propionic acid
DB-048737
DB-297233
DL-Histidine, puriss., >=99.0% (NT)
DS-012903
2-amino-3-(1H-imidazol-4-yl)propanoicacid
H0148
NS00005578
propanoic acid, 2-amino-3-(4-imidazolyl)-
2-amino-3-(3H-imidazol-4-yl)propanoic acid
EN300-33906
C00768
AB00514095-02
SR-01000596947
SR-01000596947-1
A5ADA56C-5114-4DBC-8F27-B4AD58E79ACD
Q27103201
F0452-7577
Z1259162152
HHI