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Actinomycin D

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Identification
Molecular formula
C62H86N12O16
CAS number
50-76-0
IUPAC name
2-acetamido-5-[formyl(hydroxy)amino]-N-[2-[3-[5-[3-[formyl(hydroxy)amino]propyl]-3,6-dioxo-piperazin-2-yl]propyl-hydroxy-amino]-1-(hydroxymethyl)-2-oxo-ethyl]pentanamide
State
State

Actinomycin D is typically found in a solid state at room temperature, appearing as a crystalline powder.

Melting point (Celsius)
257.00
Melting point (Kelvin)
530.15
Boiling point (Celsius)
200.00
Boiling point (Kelvin)
473.15
General information
Molecular weight
1255.42g/mol
Molar mass
1 255.4150g/mol
Density
1.1500g/cm3
Appearence

Actinomycin D is a chromopeptide antibiotic, which appears as a yellow to orange-red crystalline powder. It is very slightly soluble in water and sparingly soluble in methyl alcohol. The compound is sensitive to light, leading to gradual decomposition when exposed.

Comment on solubility

Solubility of 2-acetamido-5-[formyl(hydroxy)amino]-N-[2-[3-[5-[3-[formyl(hydroxy)amino]propyl]-3,6-dioxo-piperazin-2-yl]propyl-hydroxy-amino]-1-(hydroxymethyl)-2-oxo-ethyl]pentanamide

The solubility of the compound with the formula C62H86N12O16 is a complex matter due to its intricate molecular structure. Several factors can influence its solubility, including:

  • Molecular Weight: With a relatively high molecular weight, solubility in water may be limited.
  • Functional Groups: The presence of multiple functional groups such as amides and hydroxyl groups can enhance interactions with polar solvents.
  • Hydrophilicity vs. Hydrophobicity: The balance between hydrophilic and hydrophobic regions within the molecule is crucial; regions of higher hydrophilicity can improve solubility in water.

Generally, compounds that contain various polar and non-polar parts tend to exhibit a degree of solubility in mixed solvents. When considering potential solubility in aqueous solutions, it can energetically favor the formation of hydrogen bonds due to its hydroxyl and amine functionalities. However, due to the overall size and complexity of the structure, actual solubility might be limited.

In practical terms, solubility testing in solvents such as DMSO, methanol, and water will provide essential insights:

  • If soluble in water: suggests good bioavailability.
  • If more soluble in organic solvents: indicates potential for drug formulation in non-aqueous systems.

Ultimately, the comprehensive analysis of the solubility profile is necessary for understanding the practical applications and pharmacological properties of this compound.

Interesting facts

Interesting Facts about 2-Acetamido-5-[formyl(hydroxy)amino]-N-[2-[3-[5-[3-[formyl(hydroxy)amino]propyl]-3,6-dioxo-piperazin-2-yl]propyl-hydroxy-amino]-1-(hydroxymethyl)-2-oxo-ethyl]pentanamide

This intriguing compound belongs to a class of complex organic molecules that exhibit an array of fascinating properties and potential applications. Not solely confined to its structural intricacies, this compound plays a significant role in fields such as pharmaceuticals and biochemistry. Here are some notable points:

  • Innovative Features: The presence of multiple functional groups such as acetamido, formyl, and hydroxyamino contributes to its diverse reactivity and possible interactions with biological systems.
  • Structural Complexity: With a high molecular mass and a branched structure, it presents ample opportunities for stereochemical studies and conformational analysis.
  • Biological Significance: Compounds with this level of complexity are often explored for their potential therapeutic properties and can mimic natural substrates, enhancing their bioactivity.
  • Research Implications: The intricate design of this molecule makes it a valuable candidate in the synthesis of drugs targeting specific pathways or biological mechanisms.

As quoted by renowned chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." This spirit of exploration resonates well in the study of compounds like this one, where each unique structural element may house untapped potential for new discoveries.

In conclusion, the examination of 2-acetamido-5-[formyl(hydroxy)amino]-N-[2-[3-[5-[3-[formyl(hydroxy)amino]propyl]-3,6-dioxo-piperazin-2-yl]propyl-hydroxy-amino]-1-(hydroxymethyl)-2-oxo-ethyl]pentanamide opens up numerous avenues for research and application, underscoring the importance of structural diversity in the development of future chemicals and medicines.

Synonyms
foroxymithine
NSC612475
NSC-612475
2, 3-[3-[N-[N-(N(sup.alpha.)-acetyl-N(sup.gamma.)-formyl- N(sup.gamma.)-hydroxy-L-ornithyl)-L-seryl]-N-(hydroxy) amino]propyl]-6-[3-(N-formyl-N-hydroxyamino)propyl]-, (3S,6S)