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Fluocinolone acetonide caprylate

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Identification
Molecular formula
C32H41FO5
CAS number
35691-65-7
IUPAC name
[2-(9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] hexadecanoate
State
State

At room temperature, Fluocinolone acetonide caprylate is in a solid state. It exists as a stable powder that is not hygroscopic and does not change its state rapidly with minor temperature changes.

Melting point (Celsius)
257.15
Melting point (Kelvin)
530.30
Boiling point (Celsius)
573.15
Boiling point (Kelvin)
846.30
General information
Molecular weight
494.69g/mol
Molar mass
494.6860g/mol
Density
1.2400g/cm3
Appearence

Fluocinolone acetonide caprylate appears as a white to off-white crystalline powder. It is usually very fine and has no distinct odor. The compound may present some sheen depending on how light reflects off its crystalline surfaces.

Comment on solubility

Solubility of [2-(9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] hexadecanoate

The solubility of the compound with the chemical formula C32H41FO5 is influenced by various factors, including its molecular structure and polarity. Generally, solubility can be categorized as follows:

  • Polar vs. Nonpolar: The presence of the fluorine atom and polar functional groups (like -OH and -C=O) suggests that the compound could exhibit some degree of polarity, potentially enhancing its solubility in polar solvents such as water.
  • Hydrophobic Structures: The long hexadecanoate chain is primarily hydrophobic, which often leads to decreased solubility in polar solvents but increased solubility in nonpolar solvents like organic solvents.
  • Hydrogen Bonding: The existence of hydroxyl (-OH) groups in the structure may allow for hydrogen bonding, which can enhance solubility in suitable solvents.
  • Temperature and pH Effects: Solubility can also vary with changes in temperature and the pH of the solution, making it context-dependent.

In summary, the solubility of this compound may be moderate to low in water due to the combination of hydrophobic and polar characteristics, but potentially higher in organic solvents. Understanding these solubility properties is crucial for its application in various fields such as pharmaceuticals and chemical synthesis.

Interesting facts

Interesting Facts about 2-(9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl hexadecanoate

This compound, an intriguing molecule often studied in the context of pharmaceuticals, showcases the fascinating interplay of functional groups and structural complexity. Here's what makes it noteworthy:

  • Fluorine Influence: The presence of a fluorine atom in the structure can significantly enhance the molecule's biological activity. Fluorine atoms are often incorporated into drug design due to their ability to modify the lipophilicity and protein-binding properties of compounds.
  • Complex Structure: With multiple hydroxyl groups and a unique cyclopenta[a]phenanthrene framework, this compound illustrates the rich diversity found in organic compounds. Such complexity often leads to unique interactions with biological targets, making it a candidate for further biological evaluation.
  • Potential Therapeutic Uses: Compounds with similar structures have been explored for their potential as anti-inflammatory agents, steroid hormones, or even anticancer drugs, making this compound a subject of interest for medicinal chemists.
  • Fatty Acid Connection: The inclusion of hexadecanoate points towards potential lipophilic characteristics, which can be crucial for the pharmacokinetics of the compound, influencing absorption, distribution, metabolism, and excretion (ADME) attributes.

One can truly appreciate how the intricacies of chemical composition, structure, and functionalization come together to create molecules that could one day lead to significant advancements in medicine and therapeutics. As one researcher put it: "The pathways of chemical synthesis are often punctuated by unexpected discoveries, reminding us that every molecule holds a story waiting to be uncovered."

In summary, this compound is not just complex in its formulation; it embodies the cutting-edge of chemical research and represents the promise of innovative health solutions.

Synonyms
9-fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl hexadecanoate
DTXSID60860147
[2-(9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxoethyl] hexadecanoate
2-{9b-fluoro-1,10-dihydroxy-2,9a,11a-trimethyl-7-oxo-2H,3H,3aH,3bH,4H,5H,10H,11H-cyclopenta[a]phenanthren-1-yl}-2-oxoethyl hexadecanoate