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Fluocinolone acetonide phosphate

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Identification
Molecular formula
C24H30F1O8P
CAS number
83799-24-0
IUPAC name
[2-(9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] dihydrogen phosphate
State
State

At room temperature, fluocinolone acetonide phosphate is typically in a solid state.

Melting point (Celsius)
250.00
Melting point (Kelvin)
523.00
Boiling point (Celsius)
250.00
Boiling point (Kelvin)
523.00
General information
Molecular weight
506.48g/mol
Molar mass
506.5210g/mol
Density
1.3400g/cm3
Appearence

Fluocinolone acetonide phosphate is a white to off-white crystalline powder.

Comment on solubility

Solubility of 2-(9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl dihydrogen phosphate

The solubility of 2-(9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl dihydrogen phosphate (C24H30F1O8P) is a fascinating topic due to its complex structure and functional groups.

Generally, the solubility of compounds like this one can be influenced by several factors:

  • Polarity: The presence of polar groups such as phosphate groups often enhances solubility in polar solvents like water.
  • Molecular size: Larger molecular weight can reduce solubility due to steric hindrance.
  • Interactions: Hydrogen bonding and dipole-dipole interactions can also dictate the extent of solubility in different solvents.

In this case, the phosphate ion contributes to the potential for increased water solubility. However, the bulky steroid-like structure could hinder dissolution to some extent. Therefore, the solubility might be described best with the following characteristics:

  1. Moderately solubility in polar solvents like water.
  2. Poorly soluble in non-polar solvents due to its polar functional groups.
  3. Potential for solubility enhancement with the right pH and solvent conditions.

Ultimately, while we can deduce general characteristics about the solubility of this compound, experimental analysis would provide the most accurate information regarding its behavior in various solvents.

Interesting facts

Interesting Facts about 2-(9-Fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl dihydrogen phosphate

This compound represents a significant advancement in medicinal chemistry, particularly in the field of pharmaceuticals. Here are some noteworthy facts:

  • Complex Structure: The intricate structure of this compound includes multiple functional groups and a complex cyclopenta[a]phenanthrene core, which contributes to its unique chemical behavior and biological activity.
  • Fluorination: The presence of the fluorine atom enhances the compound's pharmacological properties, making it potentially more effective in targeting biological pathways.
  • Hydroxyl Groups: The dihydroxy groups on the molecule can facilitate hydrogen bonding, which is crucial in biological systems for molecule-receptor interactions.
  • Phosphate Group: The incorporation of a phosphate group is essential for biological activity, as it can mimic the behavior of ATP (adenosine triphosphate), a critical molecule in cellular energy transfer.
  • Potential Applications: This compound exhibits properties that might be useful in anti-cancer therapies, hormone replacement therapies, and other therapeutic areas due to its steroid-like nature.

As a scientist or a chemistry student, understanding the various components and their potential interactions can lead to exciting discoveries in drug development. The combination of structural complexity and functional diversity opens up avenues for exploration in synthetic methodologies and applications in biochemistry.

"The beauty of chemistry lies in its endless possibilities and its ability to influence life itself."

Synonyms
Betnesol
Celestone Phosphate
Linolosal
Linosal
9-fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl dihydrogen phosphate
NSC90616
.beta.-Methasonephosphate
CHEMBL2008531
DTXSID20859294
[2-(9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] dihydrogen phosphate
FB181436
NCI60_042010
NS00015667
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-,disodium salt, (11.beta.,16.beta.)-