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Clobetasol propionate

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Identification
Molecular formula
C25H32ClO5
CAS number
25122-46-7
IUPAC name
[2-(9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] propanoate
State
State

Solid at room temperature.

Melting point (Celsius)
199.00
Melting point (Kelvin)
472.15
Boiling point (Celsius)
510.15
Boiling point (Kelvin)
783.30
General information
Molecular weight
467.01g/mol
Molar mass
467.0090g/mol
Density
1.1700g/cm3
Appearence

Clobetasol propionate is a white or almost white crystalline powder.

Comment on solubility

Solubility of [2-(9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] propanoate: C25H32ClO5

The solubility of [2-(9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] propanoate is an intriguing topic due to its complex chemical structure. Here are some key points to consider regarding its solubility:

  • Polarity: The presence of multiple functional groups, such as hydroxyl (–OH) and carbonyl (C=O), can increase the polarity of the molecule, influencing its solubility in polar solvents like water.
  • Hydrophobic Regions: The molecule features hydrophobic hydrocarbon chains which may limit its solubility in water but enhance solubility in organic solvents like ethanol or chloroform.
  • Chlorine Atom: The chlorine atom could also affect solubility properties, typically contributing to increased stability and altered interactions in solution.
  • Environmental Factors: Temperature and pH may play significant roles in the solubility of this compound, as they can shift equilibrium conditions and affect solute-solvent interactions.

In conclusion, the solubility of C25H32ClO5 is likely to exhibit characteristics of both polar and non-polar behavior, depending on the solvent used, making it a compound of great interest in solubility studies.

Interesting facts

Interesting Facts about 2-(9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl propanoate

This compound, known primarily for its complex structure and diverse applications, belongs to a class of compounds that exhibit remarkable biological activity. Here are some interesting insights into this intriguing molecule:

  • Natural Product Origin: Several compounds related to this structure are derived from naturally occurring steroids, reflecting the intricate relationship between chemistry and biology.
  • Potential Therapeutic Uses: The compound has attracted attention for its potential use in medicine, particularly in fields such as oncology and anti-inflammatory therapies, thanks to its ability to interact with biological pathways.
  • Complex Synthesis: The synthesis of this molecule involves multiple steps, showcasing the challenges and creativity involved in organic chemistry. Understanding these synthetic pathways can also pave the way for the development of analogs with enhanced properties.
  • Chirality and Biological Activity: The presence of multiple chiral centers within the molecule can result in significant differences in activity. In medicinal chemistry, the configuration can drastically influence a compound's efficacy.
  • Analytical Techniques: Characterization of such complex compounds often employs advanced techniques such as NMR (Nuclear Magnetic Resonance) and MS (Mass Spectrometry) to deduce structural information and confirm the presence of functional groups.

As we unravel the intricacies of molecules like this one, we gain a deeper understanding of the connections between chemical structure and biological function, enabling the innovation of new therapeutic agents. The ongoing research into such compounds is crucial in the advancement of pharmaceutical sciences.

Synonyms
Beconase AQ
5534-09-8
9-chloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl dipropanoate
SR-05000001571
Belcoforte
Belcomet
Beclovent inhaler
NCGC00094596-03
Spectrum_000068
Spectrum2_001152
Spectrum4_000246
Spectrum5_000854
Dipropionate beclomethasone
Sch-8020W
KBioGR_000652
KBioSS_000468
DivK1c_000839
SPECTRUM1500136
SPBio_001103
SCHEMBL2404673
CHEMBL1319520
HMS502J21
KBio1_000839
KBio2_000468
KBio2_003036
KBio2_005604
DTXSID40859913
KUVIULQEHSCUHY-UHFFFAOYSA-N
NINDS_000839
HMS1920G03
HMS2091M05
Pharmakon1600-01500136
(11beta,16beta)-9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione
9-Chloro-11.beta.,17,21-trihydroxy-16.beta.-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate
CCG-40328
NSC755901
STL452897
AKOS024386978
IDI1_000839
NCGC00094596-01
NCGC00094596-02
[2-(9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxoethyl] propanoate
AS-14093
SBI-0051291.P003
AB00051922_02
SR-05000001571-1
SR-05000001571-3
BRD-A11319535-001-02-8
BRD-A11319535-001-03-6
9-Chloro-11.beta.-hydroxy-16.beta.-methyl-3,20-dioxo-17-(propionyloxy)pregna-1,4-dien-21-yl propionate #
Pregna-1-4-diene-3,20-dione, 9-chloro-16-.beta.-methyl-11-.beta.,17,21-trihydroxy-,17,21-dipropionate