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Tenofovir

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Identification
Molecular formula
C9H14N5O4P
CAS number
147127-20-6
IUPAC name
2-[[9-[3,4-dihydroxy-5-(phosphonooxymethyl)tetrahydrofuran-2-yl]purin-6-yl]amino]butanedioic acid
State
State

At room temperature, Tenofovir is a solid.

Melting point (Celsius)
279.00
Melting point (Kelvin)
552.15
Boiling point (Celsius)
400.00
Boiling point (Kelvin)
673.15
General information
Molecular weight
519.33g/mol
Molar mass
519.3250g/mol
Density
1.5000g/cm3
Appearence

Tenofovir typically appears as a white crystalline powder.

Comment on solubility

Solubility of 2-[[9-[3,4-Dihydroxy-5-(phosphonooxymethyl)tetrahydrofuran-2-yl]purin-6-yl]amino]butanedioic acid

The solubility of the compound with the formula C9H14N5O4P is influenced by several factors, including its unique structural characteristics. This compound, known for its complex functional groups, exhibits specific solubility properties:

  • Water Solubility: The presence of multiple hydroxyl (–OH) groups typically enhances solubility in polar solvents like water. Thus, this compound is expected to have good solubility in aqueous solutions.
  • Effect of pH: The ionizable groups in the molecular structure can influence solubility in different pH conditions. Under acidic conditions, for example, the compound might become more soluble due to protonation.
  • Hydrophilic Character: With phosphono and hydroxy groups present, the hydrophilic character is likely high, facilitating solubility through strong interactions with water molecules.
  • Influence of Structural Hierarchy: The specific arrangement and connectivity of the functional groups can lead to variations in solubility based on steric factors and intermolecular interactions.

In conclusion, one could summarize that the solubility of this compound is likely favorable in aqueous environments, especially under conditions that favor its ionic or polar character. Understanding its solubility is crucial for applications in medicinal chemistry and bioactive studies.

Interesting facts

Interesting Facts about 2-[[9-[3,4-Dihydroxy-5-(phosphonooxymethyl)tetrahydrofuran-2-yl]purin-6-yl]amino]butanedioic acid

This fascinating compound is known for its remarkable structure and potential applications in biochemistry and pharmacology. Here are some intriguing aspects of this compound:

  • Role in Biochemistry: This compound is a unique derivative of purine that plays a crucial role in cellular metabolism. It can serve as a nucleotide analogue, potentially influencing nucleic acid synthesis and cellular signaling pathways.
  • Medical Implications: Due to its structural similarities to nucleotides, this compound has garnered interest for its potential use in drug design, particularly in anti-viral and anti-cancer therapies. Its ability to inhibit enzymes involved in nucleic acid synthesis makes it a target for developing novel therapeutics.
  • Functional Groups: The presence of various functional groups, including hydroxyl (-OH) groups and a phosphonooxymethyl group, enhances its reactivity and solubility, making it suitable for various biological applications.
  • Complex Interactions: This compound's intricate configuration allows it to participate in diverse biochemical interactions, including enzyme-substrate binding, which can lead to innovative experimental designs in research.
  • Research Potential: Its dual nature as both an amino acid derivative and a nucleobase analogue makes it a subject of intense study. Researchers are investigating its potential influence on DNA and RNA functions, energy metabolism, and signaling in living cells.

In summary, 2-[[9-[3,4-dihydroxy-5-(phosphonooxymethyl)tetrahydrofuran-2-yl]purin-6-yl]amino]butanedioic acid stands out in the world of synthetic and natural compounds. Its unique properties render it a valuable candidate in the fields of medicinal chemistry and molecular biology. As we continue to explore its characteristics, we may unlock new pathways for treatments and a deeper understanding of cellular function.

Synonyms
Aspartyl adenylate
Adenylosuccinate;Aspartyl adenylate
2-[[9-[3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]purin-6-yl]amino]butanedioic acid
adenylosuccinate
SCHEMBL23780814