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Anhydrous Cortisone Acetate

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Identification
Molecular formula
C23H30O6
CAS number
50-04-4
IUPAC name
[2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate
State
State
Solid at room temperature.
Melting point (Celsius)
222.00
Melting point (Kelvin)
495.00
Boiling point (Celsius)
529.10
Boiling point (Kelvin)
802.20
General information
Molecular weight
402.50g/mol
Molar mass
402.4970g/mol
Density
1.3100g/cm3
Appearence

White or almost white, crystalline powder or colorless crystals.

Comment on solubility

Solubility of 2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate (C23H30O6)

The solubility of 2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate is influenced by its complex molecular structure and the presence of functional groups. This compound, containing multiple hydroxyl (-OH) groups, typically exhibits:

  • High Solubility in Polar Solvents: Due to the presence of hydroxyl groups, it is likely to be soluble in polar solvents such as water and alcohols.
  • Limited Solubility in Nonpolar Solvents: The hydrophobic regions of the compound may hinder its ability to dissolve in nonpolar solvents like hydrocarbons.

In general, compounds similar in structure often show varying degrees of solubility based on their functional groups and overall molecular geometry. As a rule of thumb:

  1. Hydrogen bonding capabilities usually enhance solubility in water.
  2. Compounds with complex, bulky structures may have reduced solubility due to steric hindrance.
  3. As with many organic compounds, slight changes in temperature can also significantly affect solubility.

Ultimately, understanding the solubility characteristics of this compound is essential for applications in pharmaceuticals, environmental chemistry, and other fields where specific interactions with solvents are crucial.

Interesting facts

Interesting Facts about 2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate

This complex organic compound may seem daunting at first glance, but it’s a fascinating example of how intricate chemical architecture can influence biological activity. Here are some engaging points to consider:

  • Natural Occurrence: This compound is a derivative related to steroid-like structures, which suggests a potential natural origin or biological relevance in certain plant or animal systems.
  • Mechanistic Insights: The compound includes a hydroxyl (-OH) group and multiple carbonyl (C=O) functionalities, which can significantly influence its reactivity and interactions in biological systems.
  • Potential Uses: Compounds similar to this one have been explored for their roles in medicine, particularly in the development of therapeutics targeting hormonal pathways. This suggests that understanding its structure may lead to valuable pharmacological insights.
  • Stereochemistry: The presence of multiple stereocenters indicates a rich stereochemical landscape, which is crucial for biological activity. Even a slight alteration in configuration could lead to markedly different properties.
  • Scientific Relevance: Researchers are keenly interested in compounds of this category for their potential in drug design, particularly in fields like oncology and endocrinology.

As one scientist expressed, “The intricate dance of atoms and bonds in such compounds reminds us of the elegance of nature itself.” This compound exemplifies that notion, embodying both complexity and beauty in its molecular structure. Engaging with compounds like this not only enriches our understanding of chemistry but also opens doors to innovative solutions in health and industry.

Synonyms
CORTISONE ACETATE
Cortisone 21-acetate
50-04-4
Cortone acetate
Incortin
Biocort acetate
Cortadren
Scheroson
Artriona
Cortisyl
Irisone acetate
Cortelan
Cortistab
Ricortex
Adreson
Corlin
Cortogen acetate
Compound E acetate
Pregn-4-ene-3,11,20-trione, 21-(acetyloxy)-17-hydroxy-
Cortisone monoacetate
NSC 49420
Cortisone, 21-acetate
Cortisone aceticum
Cortisone (acetate)
CCRIS 3661
Cortilen
11-Dehydro-17-hydroxycorticosterone-21-acetate
11-Dehydro-17-hydroxycorticosterone acetate
EINECS 200-006-5
UNII-883WKN7W8X
NSC-49420
17,21-Dihydroxypregn-4-ene-3,11,20-trione 21-acetate
883WKN7W8X
DTXSID0022858
MFCD00003609
Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy-, 21-acetate
21-(Acetyloxy)-17-hydroxypregn-4-ene-3,11,20-trione
Cortisone acetate [USP:JAN]
MLS000069478
CHEBI:3897
DTXCID502858
NSC49420
NCGC00021191-07
17-Hydroxy-3,11,20-trioxopregn-4-en-21-yl acetate
Cortisone acetate (USP:JAN)
21-Acetoxy-4-pregnen-17alpha-ol-3,11,20-trione
17,21-Dihydroxypregn-4-ene-3,11,20-trione-21-acetate
17alpha,21-dihydroxypregn-4-ene-3,11,20-trione acetate
CORTISONE ACETATE (MART.)
CORTISONE ACETATE [MART.]
17alpha,21-Dihydroxy-4-pregnene-3,11,20-trione 21-acetate
CORTISONE ACETATE (USP-RS)
CORTISONE ACETATE [USP-RS]
CAS-50-04-4
CORTISONE ACETATE (EP MONOGRAPH)
CORTISONE ACETATE [EP MONOGRAPH]
CORTISONE ACETATE (USP MONOGRAPH)
CORTISONE ACETATE [USP MONOGRAPH]
SMR000059124
Cortisone acetate (Cortone)
cortisone-acetate
Acetate cortisone
Cortisyl artriona
2-((8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
component of Neosone
Neosone (Salt/Mix)
Cortisone-21-acetate
21-Acetoxy-17,alpha-hydroxy-3,11,20-triketopregnene-4
21-Acetoxy-17,alpha-hydroxypregn-4-ene-3,11,20-trione
Cortone acetate (TN)
4-Pregnene-17,alpha,21-diol-3,11,20-trione 21-acetate
SCHEMBL4501
CHEMBL1650
Cortisone acetate (Standard)
Lopac0_000271
MLS002207136
MLS002548859
CORTISONE ACETATE [JAN]
Cortisone acetate (JP17/USP)
Cortisone 21-acetate, >=99%
CORTISONE ACETATE [VANDF]
CORTISONE ACETICUM [HPUS]
HMS2235D24
HMS3259N19
HMS3260H04
HY-17461AR
CORTISONE ACETATE [WHO-DD]
BCP08487
CORTISONE 21-ACETATE [MI]
Tox21_113482
Tox21_500271
BDBM50455157
HY-17461A
LMST02030120
AKOS005267225
Tox21_113482_1
AC-6827
CCG-204366
CORTISONE ACETATE [ORANGE BOOK]
CS-1742
DB01380
FC20559
LP00271
NC00677
SDCCGSBI-0050259.P002
NCGC00021191-03
NCGC00021191-06
NCGC00021191-08
NCGC00021191-09
NCGC00021191-16
NCGC00260956-01
[2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate
[2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
2-((1S,10S,11S,15S,2R,14R)-14-hydroxy-2,15-dimethyl-5,17-dioxotetracyclo[8.7.0 .0<2,7>.0<11,15>]heptadec-6-en-14-yl)-2-oxoethyl acetate
AS-13692
EU-0100271
NS00006620
S2559
C08173
C90609
D00973
AB00384283-08
AB00384283_09
EN300-1709694
BRD-K86161929-001-11-7
BRD-K86161929-001-13-3
HYDROCORTISONE ACETATE IMPURITY D [EP IMPURITY]
Pregn-4-ene-3,20-trione, 21-(acetyloxy)-17-hydroxy-
Z2238899644
17-Hydroxy-3,11,20-trioxopregn-4-en-21-yl acetate #
21-Acetoxy-17.alpha.-hydroxy-3,11,20-triketopregnene-4
21-Acetoxy-17.alpha.-hydroxypregn-4-ene-3,11,20-trione
4-Pregnen-17.alpha.,21-diol-3,11,20-trione 21-acetate
4-Pregnene-17alpha,21-diol-3,11,20-trione 21-acetate
Pregn-4-ene-3,20-trione, 17,21-dihydroxy-, 21-acetate
4-Pregnene-17.alpha.,21-diol-3,11,20-trione 21-acetate
Cortisone acetate, European Pharmacopoeia (EP) Reference Standard
Cortisone acetate, United States Pharmacopeia (USP) Reference Standard
Cortisone Acetate, Pharmaceutical Secondary Standard; Certified Reference Material
17,21-Dihydroxypregn-4-ene-3,11,20-trione 21 acetate;Cortone 21-acetate;21-Acetoxy-17?-hydroxy-3,11,20-triketopregnene-4
2-[(1R,3aS,3bS,9aR,9bS,11aS)-1-hydroxy-9a,11a-dimethyl-7,10-dioxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethyl acetate
200-006-5
6alpha,9Difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate 17-Butyrate