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Benztropine

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Identification
Molecular formula
C21H25NO
CAS number
132-17-2
IUPAC name
2-[(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)oxy-phenyl-methyl]aniline
State
State
Benztropine is primarily found in a solid state at room temperature. It appears as a crystalline powder and is typically supplied as a pharmaceutical solid rather than a raw compound.
Melting point (Celsius)
164.00
Melting point (Kelvin)
437.15
Boiling point (Celsius)
313.00
Boiling point (Kelvin)
586.15
General information
Molecular weight
307.42g/mol
Molar mass
307.4210g/mol
Density
1.2100g/cm3
Appearence

Benztropine is a white to off-white crystalline powder. It is usually solid under normal conditions. The compound does not have a significant odor and is often encountered in the form of a pharmaceutical preparation, either as tablets or injectable solutions.

Comment on solubility

Solubility of 2-[(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)oxy-phenyl-methyl]aniline

The solubility of 2-[(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)oxy-phenyl-methyl]aniline (C21H25NO) can be influenced by several factors, including its molecular structure, polarity, and the presence of functional groups.

Key Considerations for Solubility:

  • Polarity: This compound exhibits a mix of hydrophobic (aromatic rings) and hydrophilic (amino and oxygen-containing) characteristics, affecting its solubility in various solvents.
  • Solvent Type: It is more likely to be soluble in organic solvents such as ethanol, methanol, or dichloromethane due to its non-polar sections, while limited solubility may be observed in water.
  • Temperature: Increased temperatures can enhance solubility, promoting better interactions between the solute and solvent molecules.
  • pH Level: The ionization state of the amine group can vary with pH, potentially increasing solubility in acidic conditions.

Due to the compound's complex structure, it is crucial to conduct empirical solubility tests to gain a comprehensive understanding. "Solubility is the key to chemical reactivity and bioavailability." Therefore, monitoring solubility dynamics can greatly impact its application in pharmacological and analytical settings.

Interesting facts

Interesting Facts About 2-[(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)oxy-phenyl-methyl]aniline

This complex compound, known as 2-[(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)oxy-phenyl-methyl]aniline, is a fascinating example of how intricate molecular architectures can lead to varying biological activities. Here are some interesting insights about this compound:

  • Chemical Structure: The compound features a bicyclic structure, which is significant in medicinal chemistry due to its potential to interact with biological targets in unique ways. Bicyclic systems like this are often found in many natural products and pharmacologically active compounds.
  • Pharmacological Relevance: Compounds similar to this one are of high interest in pharmaceutical research, particularly for their potential roles as agonists or antagonists in neurotransmitter systems. The structural motif can mimic natural neurotransmitters, allowing for modulation of neuronal activity.
  • Functional Groups: With an aniline group present, this compound may exhibit properties typical of amines, including basicity and potential for hydrogen bonding. This could enhance solubility and interaction with biological membranes.
  • Synthetic Utility: The presence of the azabicyclo moiety can lead to diverse synthetic transformations, making it a versatile platform for further chemical development. Its unique structure may allow for the creation of analogs with tailored biological properties.
  • Research Applications: This compound can serve as a valuable intermediate in the synthesis of more complex molecules or in the study of receptor binding mechanisms. Scientists often use structurally similar compounds to investigate new drug leads and develop therapies.

In conclusion, 2-[(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)oxy-phenyl-methyl]aniline is a remarkable compound that showcases the diversity and potential of organic molecules in biomedical applications. Continued research into its properties could unravel new pathways in drug design, making it a worthy candidate for further exploration.

Synonyms
Aminobenztropine
88097-86-3
ABHT
2-[(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)oxy-phenylmethyl]aniline
CHEMBL330957
Benzenamine,2-[[(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)oxy]phenylmethyl]-
N-Hydroxy Metaraminol
Aminobenztropine, solid
Spectrum_000273
SpecPlus_000797
Spectrum3_000745
Spectrum4_001211
Spectrum5_001758
Lopac0_000126
BSPBio_002330
KBioGR_001642
KBioSS_000753
MLS000859976
DivK1c_006893
SPECTRUM2300334
SCHEMBL1231000
KBio1_001837
KBio2_000753
KBio2_003321
KBio2_005889
KBio3_001550
CHEBI:125384
DTXSID001007934
HMS2232P19
HMS3260I14
HMS3374M03
Tox21_500126
BDBM50080415
CCG-204221
LP00126
SDCCGSBI-0050114.P003
NCGC00015005-02
NCGC00015005-03
NCGC00015005-04
NCGC00015005-05
NCGC00015005-06
NCGC00015005-09
NCGC00093617-01
NCGC00093617-02
NCGC00093617-03
NCGC00093617-04
NCGC00260811-01
SMR000326835
A-138
EU-0100126
SR-01000075300
SR-01000075300-1
BRD-A28095882-001-05-7
Q27215827
2-[(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yloxy)-phenyl-methyl]-phenylamine
2-{[(8-Methyl-8-azabicyclo[3.2.1]octan-3-yl)oxy](phenyl)methyl}aniline