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Clobetasol propionate

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Identification
Molecular formula
C25H32ClO5
CAS number
25122-46-7
IUPAC name
[2-(7-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] propanoate
State
State

Clobetasol propionate is most commonly found as a solid in its pure form at room temperature.

Melting point (Celsius)
196.00
Melting point (Kelvin)
469.15
Boiling point (Celsius)
499.00
Boiling point (Kelvin)
772.15
General information
Molecular weight
467.98g/mol
Molar mass
467.4470g/mol
Density
1.2789g/cm3
Appearence

Clobetasol propionate typically appears as a white to cream-colored crystalline powder.

Comment on solubility

Solubility of [2-(7-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] propanoate

The solubility of the compound with the formula C25H32ClO5 can be influenced by several key factors, making it a compound of interest in various chemical and pharmaceutical applications:

  • Polarity: The presence of functional groups such as hydroxyl (-OH) and keto (C=O) significantly impacts solubility. These polar groups often enhance the solubility in polar solvents, such as water.
  • Steric Hindrance: The bulky groups in the structure may limit solubility due to the steric hindrance, making it more difficult for the molecules to interact with the solvent.
  • Solvent Compatibility: This compound is likely more soluble in organic solvents like ethanol, methanol, or dimethyl sulfoxide compared to aqueous solutions due to its overall hydrophobic molecular structure.
  • pH Dependency: Changes in pH can alter the ionization state of the compound. This variability might make it more soluble at certain pH levels depending on the protonation state of its functional groups.

In summary, while predicting solubility can be complex, the interplay of these various factors gives insight into how this compound may behave in different environments. Understanding its solubility profile is critical for its practical applications and formulations in drug development.

Interesting facts

Exploring the Fascinating Compound: 2-(7-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl propanoate

This compound, known for its intricate structure and remarkable properties, is a fantastic example of how organic chemistry can lead to substances with potential biological and therapeutic significance. Here are some captivating insights:

  • Biological Significance: Compounds with similar structures have been studied for their various biological activities, including anti-inflammatory and anticancer properties.
  • Complexity: The molecular architecture of this compound highlights the beauty of organic synthesis, showcasing a range of functional groups that contribute to its reactivity and interaction with biological targets.
  • Chirality: Due to the presence of several chiral centers, this compound may exhibit different pharmacological behaviors depending on its stereoisomers, which opens up intriguing avenues for research in chiral drugs.
  • Synthesis Challenges: The synthesis of such complex molecules often requires advanced techniques in organic synthesis, and can be a testament to the ingenuity of modern chemistry.
  • Potential Applications: The roles this compound may play in the pharmaceutical industry are vast, particularly in drug design and development aimed at targeting specific metabolic pathways.

As noted by one prominent chemist, "The exploration of complex organic compounds often leads us to surprising discoveries that can change our understanding of biology and medicine." This compound exemplifies that ethos, inviting further study and investigation into its potential uses and benefits in healthcare.

In summary, the compound not only illustrates the complexity of organic structures but also emphasizes the importance of continuing research in the field to unveil its full potential.

Synonyms
SCHEMBL13423590
DTXSID60860824
NS00002294
7-chloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl dipropanoate