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Abacavir

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Identification
Molecular formula
C14H18N6O
CAS number
136470-78-5
IUPAC name
2-[6-(cyclopentylamino)purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
State
State

At room temperature, abacavir is typically in a solid state, specifically as a powder form.

Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
341.30
Boiling point (Kelvin)
614.45
General information
Molecular weight
286.34g/mol
Molar mass
286.3350g/mol
Density
1.6803g/cm3
Appearence

Abacavir typically appears as a white to slightly yellow powder. It is crystalline in nature and is used as part of medication formulations, particularly in tablet form.

Comment on solubility

Solubility of 2-[6-(cyclopentylamino)purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

The solubility of the compound 2-[6-(cyclopentylamino)purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (C14H18N6O) is a subject of significant interest due to its unique structure and potential applications. Generally, the solubility can be influenced by various factors, including:

  • Polarity: This compound contains several functional groups that may increase its polarity, potentially enhancing solubility in polar solvents such as water.
  • Hydroxyl Groups: The presence of hydroxymethyl (-CH2-OH) groups typically suggests good solubility in water due to hydrogen bonding.
  • Amine Group: The cyclopentylamino group may also contribute to solubility in polar environments due to its basic characteristics, allowing for interactions with solvents.
  • Hydrophobic Interactions: Conversely, the cyclopentyl group introduces a hydrophobic element which could reduce solubility in aqueous environments.

Furthermore, a key point to consider is the temperature and pH of the solution, both of which can significantly affect solubility. For instance:

  • Increased temperatures often enhance solubility.
  • Variations in pH can impact the ionization of amine groups, altering solubility characteristics.

In conclusion, while the compound has features that suggest it may be soluble in polar solvents, the actual solubility profile could be complex and is likely best determined through experimental investigation. As with many compounds, understanding its solubility is crucial for practical applications in pharmacology and materials science.

Interesting facts

Interesting Facts about 2-[6-(cyclopentylamino)purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

This fascinating compound, often referred to in research circles as a potential therapeutic agent, presents a unique structure that contributes to its biological significance. Its intricate arrangement allows it to interact with various biological pathways, making it a topic of keen interest among medicinal chemists.

Biological Significance

  • Antiviral Activity: This compound has been investigated for its potential efficacy against viral infections, showcasing a promising role in antiviral drug development.
  • Cellular Impact: Its structural features enable it to influence cell signaling processes, particularly those associated with purine metabolism.
  • Research Applications: This compound serves as a crucial building block in synthesizing other pharmaceutical agents, emphasizing its importance in drug design.

Chemical Properties

The compound's complexity arises from its combination of purine and tetrahydrofuran moieties. The presence of hydroxymethyl groups contributes to its reactivity, allowing for numerous functionalization opportunities. This reactivity is fundamental for medicinal chemistry as it allows chemists to tailor compounds to optimize their biological activity.

Quotes from the Field

As noted by prominent researchers, "The integration of purine compounds in drug design has opened new avenues for combating resistant viral strains." Such insights highlight the compound's relevance in contemporary studies.

In conclusion, the compound 2-[6-(cyclopentylamino)purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol serves as an exemplary illustration of how intricate chemical structures can influence biological activity, positioning it at the forefront of pharmaceutical research.

Synonyms
2-[6-(cyclopentylamino)-9-purinyl]-5-(hydroxymethyl)oxolane-3,4-diol
2-[6-(cyclopentylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
CPA;UK-80882
MLS000859957
SCHEMBL472508
CHEMBL439718
CHEBI:91927
HMS2232A05
HMS3268A06
HMS3371J09
HMS3374C03
SMR000326816
L001289
BRD-A85234536-001-04-5
Q27163726