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2-(6-chloro-9H-carbazol-2-yl)propanoic acid

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Identification
Molecular formula
C15H12ClNO2
CAS number
77200-10-1
IUPAC name
2-(6-chloro-9H-carbazol-2-yl)propanoic acid
State
State

At room temperature, 2-(6-chloro-9H-carbazol-2-yl)propanoic acid is a solid.

Melting point (Celsius)
204.00
Melting point (Kelvin)
477.15
Boiling point (Celsius)
425.00
Boiling point (Kelvin)
698.15
General information
Molecular weight
273.73g/mol
Molar mass
273.7250g/mol
Density
1.3600g/cm3
Appearence

2-(6-chloro-9H-carbazol-2-yl)propanoic acid typically appears as a crystalline solid. Its color can vary from light yellow to off-white depending on the level of purity and specific sample preparation method.

Comment on solubility

Solubility of 2-(6-chloro-9H-carbazol-2-yl)propanoic acid

When discussing the solubility of 2-(6-chloro-9H-carbazol-2-yl)propanoic acid (C15H12ClNO2), it is essential to consider several factors that influence how this compound interacts with solvents:

  • Polarity: The presence of polar functional groups, such as the carboxylic acid in this compound, suggests that it may exhibit some degree of solubility in polar solvents, like water, but the overall solubility can be limited due to its large and bulky aromatic moiety.
  • Hydrogen bonding: The carboxylic acid part of the molecule can engage in hydrogen bonding, enhancing solubility in polar environments, yet it may still struggle with solubility in nonpolar solvents.
  • Hydrophobic interactions: The chloro substituent and carbazole structure can increase hydrophobicity, which may reduce solubility in polar solvents.

In summary, while 2-(6-chloro-9H-carbazol-2-yl)propanoic acid could potentially dissolve in water due to its acidic group, the presence of hydrophobic characteristics can lead to challenges in achieving significant solubility.
Thus, the solubility profile in various solvents would require empirical evaluation to determine the actual behavior of this compound.

Interesting facts

Interesting Facts about 2-(6-chloro-9H-carbazol-2-yl)propanoic acid

2-(6-chloro-9H-carbazol-2-yl)propanoic acid is a fascinating compound that bridges the fields of organic chemistry and material science. This compound is noteworthy for several reasons:

  • Pharmaceutical Potential: Compounds related to carbazole structures often possess significant biological activities. The presence of a chloro substituent can enhance the pharmacological profiles of these compounds, making them interesting candidates for drug development.
  • Structural Versatility: The carbazole moiety is a building block in organic synthesis, and its unique structure allows for various functionalizations. This opens up avenues for creating complex molecules with tailored properties.
  • Optoelectronic Applications: Compounds like this one are explored in the development of organic light-emitting diodes (OLEDs) and organic photovoltaic devices, where their electronic properties can be exploited for efficient light emission and energy conversion.
  • Carbazole Chemistry: The presence of the carbazole group in this compound links it to a family of compounds known for their interesting optical and electronic characteristics, which make them valuable in both research and commercial applications.

The study of 2-(6-chloro-9H-carbazol-2-yl)propanoic acid not only enhances our understanding of organic compounds but also contributes to advancements in medicine and technology. As scientists delve deeper into its properties and potential applications, this compound may pave the way for innovative solutions in various industries.

Synonyms
carprofen
53716-49-7
2-(6-Chloro-9H-carbazol-2-yl)propanoic acid
Rimadyl
Imadyl
Carprofeno
Carprofene
Ridamyl
Carprofenum
6-Chloro-alpha-methyl-9H-carbazole-2-acetic acid
Carprodyl
Carprofene [INN-French]
Carprofenum [INN-Latin]
Carprofeno [INN-Spanish]
6-Chloro-alpha-methylcarbazole-2-acetic acid
Ro 20-5720/000
Carpaquin
Norocarp
MFCD00079028
52263-47-5
Ro 20-5720
CCRIS 3507
C 5720
rac Carprofen
(+-)-6-Chloro-alpha-methylcarbazole-2-acetic acid
UNII-FFL0D546HO
Carprofen for veterinary use
EINECS 258-712-4
FFL0D546HO
NSC 297935
NSC-297935
2-(6-Chloro-9H-carbazol-2-yl)-propionic acid
BRN 0487098
DTXSID1045871
(+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid
CHEBI:364453
Ro-20-5720/000
CHEMBL1316
Ro-205720000
DTXCID9025871
Carprofen [USAN:USP:INN:BAN]
(+-)-6-Chlor-alpha-methyl-2-carbazolessigsaeure
5-22-03-00391 (Beilstein Handbook Reference)
(+/-)-6-Chloro-alpha-methylcarbazole-2-acetic acid
NSC297935
9H-Carbazole-2-acetic acid, 6-chloro-.alpha.-methyl-
NCGC00094937-01
Carprofeno [Spanish]
9H-CARBAZOLE-2-ACETIC ACID, 6-CHLORO-alpha-METHYL-, (+-)-
Carprofene (INN-French)
Carprofenum (INN-Latin)
Carprofeno (INN-Spanish)
CARPROFEN (MART.)
CARPROFEN [MART.]
CARPROFEN (USP-RS)
CARPROFEN [USP-RS]
2-(6-chloro-9H-carbazol-2-yl)-3,3,3-trideuteriopropanoic acid
(.+-.)-6-Chloro-.alpha.-methylcarbazole-2-acetic acid
CARPROFEN (USP IMPURITY)
CARPROFEN [USP IMPURITY]
CARPROFEN (USP MONOGRAPH)
CARPROFEN [USP MONOGRAPH]
Carprofen (USAN:USP:INN:BAN)
SMR000718633
Rimadyl (TN)
CAS-53716-49-7
SR-01000837515
CARPROFEN FOR VETERINARY USE (EP MONOGRAPH)
CARPROFEN FOR VETERINARY USE [EP MONOGRAPH]
Carprieve
Carprovet
Levafen
Quellin
RimadylCaplets
RimadylSterile
Vetprofen
Rovera
OstiFen
Rimadyl Caplets
Carprofen; (2RS)-2-(6-Chloro-9H-carbazol-2-yl)propanoic acid
carprofen flavored
Carprofen Tablets
Carprieve Injection
Carprofen Injection
MOVODYL
Carprofen (Standard)
Ro-20-5720
Carprofen (USP/INN)
CARPROFEN [INN]
CARPROFEN [MI]
Rimadyl Chewable Tablets
CARPROFEN [USAN]
Spectrum2_001236
Spectrum3_000939
Spectrum4_001038
Spectrum5_001802
CARPROFEN [VANDF]
Carprieve Chewable Tablets
Carprofen Chewable Tablets
Carprofen Flavored Tablets
(R)-alpha-Methyl-6-chloro-9H-carbazole-2-acetic acid
(S)-alpha-Methyl-6-chloro-9H-carbazole-2-acetic acid
C-5720
CARPROFEN [WHO-DD]
SCHEMBL3909
KBioGR_001595
TRUPROFEN FLAVORED TAB
MLS001201778
MLS001306441
SPECTRUM1502006
SPBio_001112
CARPROFEN [GREEN BOOK]
GTPL7141
CARPROFEN [ORANGE BOOK]
(+/-)-6-Chloro-.alpha.-methylcarbazole-2-acetic acid
Carprofen, >=97% (HPLC)
Carprofen Caplets, Novox Caplets
HY-B1227R
KBio3_001978
GLXC-20198
HMS1921D04
HMS2092B16
HMS2234P15
HMS3652E20
HMS3715F09
HMS3748C07
HMS3885F07
Pharmakon1600-01502006
Rimadyl Sterile Injectable Solution
HY-B1227
Tox21_111363
9H-Carbazole-2-acetic acid, 6-chloro-.alpha.-methyl-, (.+-.)-
BBL009935
BDBM50097346
Carprofen Sterile Injectable Solution
CCG-39146
NSC758154
STK711093
9H-Carbazole-2-acetic acid, (-)-
AKOS005530663
Tox21_111363_1
AC-1266
CS-4875
DB00821
FC31969
KS-1163
NSC-758154
NCGC00094937-02
NCGC00094937-04
NCGC00094937-05
9H-Carbazole-2-acetic acid, (.+-.)-
SY052509
Carprofen 1000 microg/mL in Acetonitrile
SBI-0052885.P002
C2701
NS00008183
S4136
SW199610-3
6-chloro-alpha-methyl-carbazole-2-acetic acid
Carprofen, VETRANAL(TM), analytical standard
6-Chloro-?-methyl-9H-carbazole-2-acetic acid
C18364
D03410
D70911
EN300-120629
2-(6-chloranyl-9H-carbazol-2-yl)propanoic acid
AB00876263_06
AB00876263_07
A829748
Q905755
(RS)-2-(6-Chloro-9H-carbazol-2-yl)propanoic acid
SR-01000837515-2
SR-01000837515-3
BRD-A17411484-001-05-1
BRD-A17411484-001-10-1
BRD-A17411484-001-11-9
Z1530425063
2-(6-Chloro-9H-carbazol-2-yl)-propionic acid(carprofen)
Carprofen, European Pharmacopoeia (EP) Reference Standard
9H-Carbazole-2-acetic acid, 6-chloro-.alpha.-methyl-, (-)-
Carprofen, United States Pharmacopeia (USP) Reference Standard
9H-CARBAZOLE-2-ACETIC ACID, 6-CHLORO-alpha-METHYL, (+/-)-
9H-CARBAZOLE-2-ACETIC ACID, 6-CHLORO-.ALPHA.-METHYL, (+/-)-
Carprofen, Pharmaceutical Secondary Standard; Certified Reference Material
Carprofen for system suitability, European Pharmacopoeia (EP) Reference Standard
258-712-4
6-Chloro-a-methyl-9H-carbazole-2-acetic acid;(dl)-6-Chloro-a-methylcarbazole-2-acetic acid;RS-Carprofen