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Benzimidazole

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Identification
Molecular formula
C13H12N4
CAS number
41859-89-8
IUPAC name
2-[(6-carbamimidoyl-1H-benzimidazol-2-yl)methyl]-3H-benzimidazole-5-carboxamidine
State
State

At room temperature, benzimidazole compounds are usually solid. They are stable under normal conditions and do not decompose easily. The solid form contributes to their wide use in pharmaceuticals where precise measurements and forms are required.

Melting point (Celsius)
171.00
Melting point (Kelvin)
444.20
Boiling point (Celsius)
791.90
Boiling point (Kelvin)
1 065.10
General information
Molecular weight
209.26g/mol
Molar mass
209.2500g/mol
Density
1.3700g/cm3
Appearence

Benzimidazole compounds typically appear as off-white to pale yellow solids. They are crystalline in nature and can form fine powders or larger crystalline structures. The compounds under this category may have a slight odor, but often it’s negligible at room temperature.

Comment on solubility

Solubility of 2-[(6-carbamimidoyl-1H-benzimidazol-2-yl)methyl]-3H-benzimidazole-5-carboxamidine

The compound 2-[(6-carbamimidoyl-1H-benzimidazol-2-yl)methyl]-3H-benzimidazole-5-carboxamidine, with the chemical formula C13H12N4, presents interesting solubility characteristics which can be influenced by a variety of factors:

  • Polarity: The presence of multiple nitrogen atoms suggests that this compound may exhibit moderate to high polarity, which typically increases solubility in polar solvents.
  • Solvent Interaction: Due to its structural complexity, the solubility may vary greatly depending on the solvent. It is likely to be soluble in water and various organic solvents, especially those capable of hydrogen bonding.
  • pH Dependency: As a carboxamidine, the solubility may also be affected by the pH of the solution, potentially becoming more soluble under acidic conditions where protonation can occur.
  • Temperature Influence: Temperature plays a critical role in solubility; generally, increasing temperature enhances solubility of solids.

It is essential to conduct experimental solubility tests for accurate measurements, as theoretical predictions may not fully capture the behavior of complex organic compounds in solution. Further studies are required to delineate the exact solubility profile under varying environmental conditions.

Interesting facts

Interesting Facts about 2-[(6-carbamimidoyl-1H-benzimidazol-2-yl)methyl]-3H-benzimidazole-5-carboxamidine

This intriguing compound, known as 2-[(6-carbamimidoyl-1H-benzimidazol-2-yl)methyl]-3H-benzimidazole-5-carboxamidine, belongs to the class of compounds that feature benzimidazole, a structure well known for its various biological activities. Here are some captivating aspects of this compound:

  • Biological Significance: Benzimidazole derivatives have gained considerable attention in medicinal chemistry due to their diverse biological properties, including antimicrobial, anti-inflammatory, and anticancer activities.
  • Structure-Activity Relationship: The substitution pattern on the benzene rings in this compound can significantly affect its pharmacological properties, making it a subject of study for drug design. The presence of the carboxamidine functional group is particularly noteworthy, as it can enhance the biological activity and solubility of the compound.
  • Potential Applications: Compounds with similar structures have been explored for use in treating various diseases, including infections, cancer, and neurological disorders. Thus, understanding the effects of this specific compound might lead to advancements in therapeutic options.
  • Research Opportunities: This compound’s unique molecular design provides a rich field for further investigation. Scientists could explore its mechanism of action, efficacy, and safety profiles through both in vitro and in vivo studies.
  • Synthesis Challenges: The intricate synthesis of such compounds can present challenges due to the need for precise control over reaction conditions. Mastery of organic synthesis techniques is crucial for chemists working with such derivatives.

In essence, 2-[(6-carbamimidoyl-1H-benzimidazol-2-yl)methyl]-3H-benzimidazole-5-carboxamidine represents a promising avenue for scientific exploration that bridges the gaps between chemistry and therapeutic development. As research continues, it may reveal even more mysteries and applications that could significantly impact the field of medicinal chemistry.

Synonyms
BABIM
74733-75-8
Bis(5-amidino-2-benzimidazolyl)methane
1c1v
CHEMBL99951
1H-Benzimidazole-5-carboximidamide, 2,2'-methylenebis-
DTXSID60225717
2-[(6-carbamimidoyl-1H-benzimidazol-2-yl)methyl]-3H-benzimidazole-5-carboximidamide
1H-Benzimidazole-6-carboximidamide,2,2'-methylenebis-
1xug
SCHEMBL65730
BDBM16127
DTXCID90148208
AIDS007118
2,2 -methanediylbis(1H-benzimidazole-6-carboximidamide)
2,2'-Methylenebis(1H-benzo[d]imidazole-5-carboximidamide)
2-[(5-carbamimidoyl-1H-benzimidazol-2-yl)methyl]-1H-benzimidazole-5-carboxamidine
2-[(6-carbamimidoyl-1H-1,3-benzodiazol-2-yl)methyl]-1H-1,3-benzodiazole-6-carboximidamide