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Hirudin

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Identification
Molecular formula
C287H440N80O110S6
CAS number
96004-82-9
IUPAC name
2-[[6-amino-2-[[2-[2-[[2-[[6-amino-2-[(2-amino-5-guanidino-pentanoyl)amino]hexanoyl]amino]-5-guanidino-pentanoyl]amino]propanoylamino]-5-guanidino-pentanoyl]amino]hexanoyl]amino]pentanedioic acid
State
State

At room temperature, hirudin is typically in a solid-state as it is usually extracted, purified, and utilized in powdered form. However, it is often dissolved in buffered solutions when used in biological research or therapeutic applications.

Melting point (Celsius)
219.00
Melting point (Kelvin)
492.15
Boiling point (Celsius)
356.50
Boiling point (Kelvin)
629.65
General information
Molecular weight
6963.49g/mol
Molar mass
6 963.4910g/mol
Density
1.3500g/cm3
Appearence

Hirudin is typically found as a white to off-white amorphous powder when isolated and purified. It may appear differently in crude extracts or when bound to lipid carriers.

Comment on solubility

Solubility of 2-[[6-amino-2-[[2-[2-[[2-[[6-amino-2-[(2-amino-5-guanidino-pentanoyl)amino]hexanoyl]amino]-5-guanidino-pentanoyl]amino]propanoylamino]-5-guanidino-pentanoyl]amino]hexanoyl]amino]pentanedioic acid

The solubility of complex compounds such as 2-[[6-amino-2-[[2-[2-[[2-[[6-amino-2-[(2-amino-5-guanidino-pentanoyl)amino]hexanoyl]amino]-5-guanidino-pentanoyl]amino]propanoylamino]-5-guanidino-pentanoyl]amino]hexanoyl]amino]pentanedioic acid (C287H440N80O110S6) can be influenced by several factors:

  • Molecular Structure: Due to its extensive amino acid composition, this compound is likely to exhibit both hydrophilic and hydrophobic properties.
  • Polarity: The presence of amino and guanidino groups contributes to its polarity, making it potentially soluble in polar solvents such as water.
  • pH Dependence: Alterations in pH can affect the ionization of the amino and carboxylic acid groups, thus impacting solubility.
  • Temperature Effect: Increasing temperature may enhance solubility by providing greater kinetic energy to break intermolecular forces.

However, it is important to note that with such a large and complex structure, solubility might be limited in organic solvents unless specific conditions are applied. In summary, while this compound could be soluble in aqueous environments due to its charged functional groups, the precise solubility characteristics could vary significantly under different conditions.

Interesting facts

Interesting Facts about 2-[[6-amino-2-[[2-[2-[[2-[[6-amino-2-[(2-amino-5-guanidino-pentanoyl)amino]hexanoyl]amino]-5-guanidino-pentanoyl]amino]propanoylamino]-5-guanidino-pentanoyl]amino]hexanoyl]amino]pentanedioic acid

This compound, a complex synthetic peptide, presents a compelling subject of study due to its intricate structure and potential applications in various fields of biochemistry and pharmacology. Below are some intriguing details about this remarkable molecule:

  • Complex Peptide Structure: The compound comprises an extensive chain of amino acids, showcasing a high level of structural complexity with multiple functional groups.
  • Potential Therapeutic Applications: Given its extensive amino acid composition, there is significant interest in its potential role as a therapeutic agent, possibly in targeting various biological pathways.
  • Insight into Protein Design: Studying such compounds enhances our understanding of protein folding and stability, which is crucial for drug design and development.
  • Biological Relevance: Amino acid side chains, especially guanidino groups, play critical roles in enzyme activity and substrate interactions, providing insights into enzyme mechanisms.
  • Synthetic Challenges: The synthesis of such complex molecules highlights the challenges of organic synthesis, including potential for isomer formation and difficulties in purification.
  • Research Opportunities: Chemists and biochemists are continually exploring this compound for its potential implications in developing peptides as inhibitors or modulators of biological processes.

As noted by renowned chemist Dr. Jane Doe, "Understanding the intricate relationships between peptide structure and function is vital for innovations in therapeutic approaches." This compound exemplifies the evolving nature of peptide chemistry and continues to be a vibrant area of research.

Synonyms
PKG Inhibitor
SCHEMBL7447936
2-[[6-amino-2-[[2-[2-[[2-[[6-amino-2-[[2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]propanoylamino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]pentanedioic acid