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Abacavir

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Identification
Molecular formula
C14H18N6O
CAS number
136470-78-5
IUPAC name
2-[6-[(4-aminophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
State
State

At room temperature, Abacavir is in the solid state as a crystalline powder. It is stable under normal conditions but should be stored in a cool, dry place to preserve its integrity.

Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
726.70
Boiling point (Kelvin)
999.90
General information
Molecular weight
286.33g/mol
Molar mass
286.3310g/mol
Density
1.6000g/cm3
Appearence

Abacavir is typically encountered as a white to off-white crystalline solid. It is a nucleoside reverse transcriptase inhibitor (NRTI) used as an antiretroviral medication to prevent and treat HIV/AIDS. The appearance can sometimes be slightly hygroscopic, absorbing moisture from the air.

Comment on solubility

Solubility of 2-[6-[(4-aminophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

The solubility of the compound 2-[6-[(4-aminophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (C14H18N6O) can be quite intricate, influenced by various factors such as temperature, pH, and solvent type. This compound features several functional groups that can interact with solvents, rendering its solubility profile unique. Here are some key points to consider:

  • Hydrophilicity vs. Hydrophobicity: The presence of polar functional groups such as hydroxymethyl and amino groups suggests that this compound is more likely to be soluble in polar solvents, like water.
  • Temperature Dependence: Like many organic compounds, its solubility may increase with temperature, allowing for greater interaction with solvent molecules.
  • pH Sensitivity: Changes in pH can significantly affect the ionization of the amino groups, which can alter solubility in aqueous solutions.
  • Practical Solubility: In practice, this compound may exhibit limited solubility in nonpolar solvents due to its polar nature, indicating a strong preference for more polar environments.

Moreover, understanding the solubility characteristics of this compound is vital for applications in pharmaceuticals and biochemical research, as solubility often governs the efficacy and bioavailability of drug molecules. Consequently, extensive studies examining the compound's solubility under varying conditions would provide valuable insights for further development.

Interesting facts

Interesting Facts about 2-[6-[(4-aminophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

This fascinating compound, often abbreviated in the chemistry community, represents a unique scaffold in medicinal chemistry, showcasing innovative approaches to drug design. Below are some intriguing aspects of this compound:

  • Pharmacological Potential: The structure of this compound suggests potential applications in several therapeutic areas, particularly in nucleic acid metabolism, as it contains purine derivatives.
  • Structural Complexity: At first glance, its chemical structure is complex, involving multiple functional groups that contribute to its biological activity.
  • Targeted Delivery: The hydroxymethyl group plays a critical role in enhancing solubility and biological activity, making it a candidate for targeted drug delivery systems.
  • Amino Group Influence: The presence of the amine functional group exhibits potential for interactions with biological receptors, increasing the likelihood of therapeutic efficacy.

As a scientist delving into the world of chemical compounds, it is integral to appreciate how perturbations in structure can lead to significant changes in biological activity. This compound serves as a prime example of how tiny modifications can yield diverse pharmacological outcomes. Exploring its synthesis and practical applications could provide profound insights into advanced therapeutic strategies.

In the realm of ongoing research, this compound might inspire several lines of inquiry, including:

  1. Investigating its mechanism of action at the molecular level.
  2. Assessing its effectiveness against specific disease targets.
  3. Evaluating its safety profile in various biological models.

With ongoing advancements in organic synthesis and analytical methods, the full potential of this compound and similar structures is yet to be realized. The exploration of such compounds can lead to groundbreaking discoveries in pharmacology.

Synonyms
SCHEMBL20626394
2-[6-[(4-aminophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol