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Clofarabine

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Identification
Molecular formula
C10H11Cl2N5O3
CAS number
123318-82-1
IUPAC name
2-(5,6-dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
State
State

Clofarabine is typically in a solid state at room temperature.

Melting point (Celsius)
175.00
Melting point (Kelvin)
448.20
Boiling point (Celsius)
680.40
Boiling point (Kelvin)
953.60
General information
Molecular weight
303.68g/mol
Molar mass
303.6780g/mol
Density
1.7600g/cm3
Appearence

Clofarabine appears as a white to off-white solid that is odorless.

Comment on solubility

Solubility of 2-(5,6-dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

The solubility of the compound 2-(5,6-dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (C10H11Cl2N5O3) can be influenced by a variety of factors. Understanding its solubility characteristics is key to its potential applications.

Key Considerations for Solubility:

  • Polarity: The presence of multiple functional groups, including hydroxymethyl and amine, suggests that it has moderate polarity, which may allow it to dissolve better in polar solvents such as water.
  • Chlorine Atoms: The inclusion of chlorinated phenyl groups can introduce hydrophobic characteristics, which may reduce solubility in highly polar solvents.
  • Hydrogen Bonding: The hydroxymethyl and hydroxyl groups can engage in hydrogen bonding, potentially enhancing solubility in water and other polar solvents.

In summary, while the hydrophilic nature due to hydroxyl functionalities might favor solubility in polar environments, the chlorinated components may introduce challenges. Therefore, the solubility of this compound is likely to be balanced between hydrophobic and hydrophilic interactions, making it interesting for various solvent systems. Experimentation is crucial to determine its precise solubility profile.

Interesting facts

Interesting Facts about 2-(5,6-Dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

This intriguing compound is a member of the benzimidazole family, known for its diverse range of biological activities. Here are some fascinating insights about this compound:

  • Biological Significance: Compounds containing the benzimidazole moiety have been extensively researched for their pharmaceutical properties, including anti-cancer, anti-fungal, and anti-viral activities.
  • Structural Features: The presence of a tetrahydrofuran ring significantly impacts the compound’s pharmacokinetics, allowing it to interact effectively with various biological targets.
  • Dichlorination: The dichlorobenzimidazole part of the structure adds to its reactivity and may provide enhanced efficacy in certain biological applications.
  • Applications: This compound could potentially be explored in the development of new drugs, particularly in the area of infectious diseases, owing to its unique structural attributes.
  • Synthesis Pathways: The synthetic routes for creating compounds like this often involve complex multi-step processes that require precision and a deep understanding of organic chemistry.

In summary, 2-(5,6-dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol is not just another chemical entity but a potential candidate for innovative therapeutic solutions. As science advances, compounds like this might unlock new frontiers in medicinal chemistry.

Synonyms
(2R,3R,4S,5R)-2-(5,6-dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol
MLS003171503
2-(5,6-dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol
5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole
DRB;
NSC401575
5,6-dichlororibofuranosylbenzimidazole
Kinome_3639
1-beta-D-ribofuranosyl-5,6-dichlorobenzimidazole
5,6-dichloro-1-(beta-d-ribofuranosyl)benzimidazole
CHEMBL267071
SCHEMBL20419020
SCHEMBL23982247
CHEBI:49852
CHEBI:232947
HMS3373F12
NCGC00096104-01
NCGC00096104-02
SMR001875388
5,6-Dichlorobenzimidazole 1-b-D-ribofuranoside
5,6-dichloro-1-beta-d-ribofuranosylbenzimi-dazole
Benzimidazole,6-dichloro-1-.beta.-D-ribofuranosyl-
1H-Benzimidazole,6-dichloro-1-.beta.-D-ribofuranosyl-
Dichlorobenzimidazole Riboside, DRB (5,6-Dichloro-1-b-D-ribofuranosylbenzimidazole)