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Ketoprofen

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Identification
Molecular formula
C16H14O3S
CAS number
22071-15-4
IUPAC name
2-(5-benzoyl-2-thienyl)propanoic acid
State
State

Ketoprofen is typically in a solid state at room temperature.

Melting point (Celsius)
95.50
Melting point (Kelvin)
368.65
Boiling point (Celsius)
761.50
Boiling point (Kelvin)
1 034.65
General information
Molecular weight
254.28g/mol
Molar mass
254.2810g/mol
Density
1.2000g/cm3
Appearence

Ketoprofen appears as a white or slightly yellowish crystalline powder. It is usually odorless or has a faint odor, and it is slightly soluble in water, but freely soluble in acetone and methanol.

Comment on solubility

Solubility of 2-(5-benzoyl-2-thienyl)propanoic acid (C16H14O3S)

The solubility of 2-(5-benzoyl-2-thienyl)propanoic acid can be influenced by various factors, including its molecular structure and the presence of functional groups. This compound is composed of a thienyl moiety, a carboxylic acid group, and a benzoyl substituent, which collectively impact its solubility in different solvents.

Key Points on Solubility:

  • Polar vs. Non-Polar Solvents: Due to its carboxylic acid functional group, 2-(5-benzoyl-2-thienyl)propanoic acid tends to exhibit higher solubility in polar solvents such as water and alcohols. In contrast, it may show limited solubility in non-polar solvents.
  • Temperature Influence: Solubility is generally enhanced with increased temperature, meaning that solubility measurements should be conducted at defined temperatures to ascertain accurate values.
  • Hydrogen Bonding: The presence of the carboxylic acid allows the molecule to participate in hydrogen bonding, enhancing its capacity to dissolve in polar solvents.
  • Potential Applications: The solubility characteristics of this compound make it useful in pharmaceuticals, where solubility can influence bioavailability and therapeutic efficacy.

In summary, while the precise solubility of 2-(5-benzoyl-2-thienyl)propanoic acid in various solvents may require experimental determination, its intrinsic polar characteristics suggest favorable solubility in polar environments compared to non-polar. Understanding these solubility properties is crucial for various applications in chemical science.

Interesting facts

Exploring 2-(5-benzoyl-2-thienyl)propanoic acid

2-(5-benzoyl-2-thienyl)propanoic acid is an intriguing compound that combines both organic and medicinal chemistry attributes, showcasing the rich intersection of diverse chemical functionalities.

Key Features

  • Structural Composition: This compound features an aromatic thienyl group, suggesting strong conjugation and distinctive reactivity patterns. Its structure consists of a thienyl ring connected to a propanoic acid derivative, which adds acidity to its profile.
  • Pharmaceutical Relevance: Compounds like this one are often explored for their potential in drug development, influencing pain management and anti-inflammatory treatments due to the presence of the carboxylic acid group.
  • Materials Science Applications: The unique properties of the thienyl ring may also open doors for applications in materials science, particularly in the design of organic semiconductors and photonic devices.

Scientific Insights

This compound serves as a perfect example of how intricate organic compounds can tailor their properties through subtle structural modifications. Research has shown that:

  • Thienyl compounds exhibit significant electron-rich characteristics, making them valuable in various organic synthesis pathways.
  • The integration of benzoyl groups contributes to greater stability and enhances the overall reactivity profile of the molecule.

As noted by many chemists, "The beauty of organic compounds lies in their complexity and the stories hidden in their structures." Such compounds challenge students and scientists alike to unravel the intricate dance of atoms that leads to their unique applications. As we delve deeper into the study of compounds like 2-(5-benzoyl-2-thienyl)propanoic acid, we unveil not only their potential uses in various domains but also the fundamental principles of chemical interactions and reactivity.

Synonyms
tiaprofenic acid
33005-95-7
Surgam
2-(5-benzoylthiophen-2-yl)propanoic acid
Tiaprofensaeure
Acido tiaprofenico
Acide tiaprofenique
Acidum tiaprofenicum
2-[5-(phenylcarbonyl)-2-thienyl]propanoic acid
tiaprofen
5-Benzoyl-alpha-methyl-2-thiopheneacetic acid
2-(5-Benzyl-2-thienyl)propionsaeure
Surgam SA
Acide tiaprofenique [INN-French]
Acido tiaprofenico [INN-Spanish]
Acidum tiaprofenicum [INN-Latin]
RU 15060
Tiaprofenate
Suralgan
FC 3001
Surgam (TN)
alpha-methyl-5-benzoyl-2-thienylacetic acid
Tiaprofenic acid [INN:BAN:DCF:JAN]
CHEBI:32221
EINECS 251-329-3
UNII-1LS1T6R34C
5-benzoyl-alpha-methylthiophene-2-acetic acid
BRN 1380662
1LS1T6R34C
DTXSID5023665
RU-15060
TIAPROFENIC ACID [MI]
TIAPROFENIC ACID [INN]
TIAPROFENIC ACID [JAN]
DTXCID303665
2-(5-Benzoyl-thiophen-2-yl)-propionic acid
TIAPROFENIC ACID [MART.]
TIAPROFENIC ACID [WHO-DD]
2-Thiopheneacetic acid, 5-benzoyl-alpha-methyl-
5-Benzoyl-.alpha.-methyl-2-thiopheneacetic acid
5-18-08-00405 (Beilstein Handbook Reference)
2-Thiopheneacetic acid, 5-benzoyl-.alpha.-methyl-
TIAPROFENIC ACID [EP IMPURITY]
TIAPROFENIC ACID [EP MONOGRAPH]
2-(5-Benzoyl-2-thienyl)propanoic acid
Nu-Tiaprofenic
Novo-Tiaprofenic
PMS-Tiaprofenic
TIAPROFENIC ACID (MART.)
Acide tiaprofenique (INN-French)
Acido tiaprofenico (INN-Spanish)
Acidum tiaprofenicum (INN-Latin)
Flanid
Apo-Tiaprofenic
TIAPROFENIC ACID (EP IMPURITY)
TIAPROFENIC ACID (EP MONOGRAPH)
Tiaprofensaure
Tiaprofenic acid; (2RS)-2-(5-Benzoylthiophen-2-yl)propanoic acid
NCGC00016815-01
Prestwick_814
CAS-33005-95-7
MFCD00866089
Surgam 200
Surgam 300
2-(5-Benzoylthiophen-2-yl)propanoicacid
Prestwick0_000496
Prestwick1_000496
Prestwick2_000496
Prestwick3_000496
Epitope ID:131796
Tiaprofenic acid (Standard)
SCHEMBL25639
BSPBio_000391
MLS002153845
SPBio_002312
BPBio1_000431
CHEMBL365795
M01AE11
BDBM223313
HMS1569D13
HMS2096D13
HMS2230E19
HMS3372D06
HMS3713D13
EX-A4101
Tox21_110627
2-(5-Benzyl-2-thienyl)propionsaure
s5661
STL454339
(5-benzoyl-2-thienyl)-propionic acid
AKOS015969058
Tox21_110627_1
AC-8970
CCG-220496
DB01600
HY-106579R
NCGC00179573-03
AS-77449
SMR001233207
2-(5-Benzoyl-2-thienyl)propanoic acid #
2-(5-Benzoylthiophen-2-yl)propionic Acid
alpha-(5-benzoyl-2-thienyl)propionic acid
HY-106579
CS-0026096
NS00009970
T3175
(RS)-2-(5-benzoyl-2-thienyl)propanoic acid
A10805
D01325
EN300-7382798
Q419926
SR-01000841193
2-[5-(phenylcarbonyl)thiophen-2-yl]propanoic acid
SR-01000841193-2
BRD-A72988804-001-03-8
BRD-A72988804-001-10-3
BRD-A72988804-001-11-1
251-329-3