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Topotecan

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Identification
Molecular formula
C23H23N3O5
CAS number
123948-87-8
IUPAC name
2-[5-[(3-methyl-1-oxo-4H-benzo[f]quinazolin-9-yl)methylamino]-1-oxo-isoindolin-2-yl]pentanedioic acid
State
State

At room temperature, Topotecan is a crystalline solid. It is used in its solid form for manufacturing and pharmaceutical purposes before being processed as required for therapeutic applications.

Melting point (Celsius)
213.00
Melting point (Kelvin)
486.15
Boiling point (Celsius)
845.00
Boiling point (Kelvin)
1 118.15
General information
Molecular weight
421.45g/mol
Molar mass
421.4280g/mol
Density
1.7630g/cm3
Appearence

Topotecan is typically observed as a yellow to orange crystalline powder. It is hygroscopic, meaning that it readily absorbs moisture from the environment, which may cause it to appear slightly clumpy under certain conditions.

Comment on solubility

Solubility of 2-[5-[(3-methyl-1-oxo-4H-benzo[f]quinazolin-9-yl)methylamino]-1-oxo-isoindolin-2-yl]pentanedioic acid

The solubility of a compound like 2-[5-[(3-methyl-1-oxo-4H-benzo[f]quinazolin-9-yl)methylamino]-1-oxo-isoindolin-2-yl]pentanedioic acid (C23H23N3O5) can vary significantly based on several factors. Solubility is a critical property impacting the compound's utility in various applications, particularly in pharmaceuticals and materials science.

Factors Influencing Solubility:

  • Polarity: Compounds that are polar tend to be more soluble in polar solvents such as water. The structure of this compound includes functional groups that could potentially enhance its polarity.
  • Temperature: Generally, increasing the temperature can improve solubility for many solids in liquids.
  • pH Levels: The solubility may also be affected by the pH of the environment, particularly if the compound can ionize.
  • Presence of Other Solutes: The interaction between solutes in a solution can either hinder or assist in the dissolving process.

In conclusion, understanding the solubility of this compound requires a careful examination of these factors. Its complex structure suggests that it might showcase varying solubility patterns across different solvents, which should be explored further to determine its practical applications. As a point of interest, compounds with multifaceted structures often exhibit unique solubility behaviors that challenge convention, making them subjects of intriguing study in the field of chemical science.

Interesting facts

Interesting Facts about 2-[5-[(3-methyl-1-oxo-4H-benzo[f]quinazolin-9-yl)methylamino]-1-oxo-isoindolin-2-yl]pentanedioic acid

This intriguing compound is a member of the class of benzoquinazoline derivatives, a structure that has gained significant attention for its diverse biological activities. Here are some fascinating insights:

  • Pharmacological Potential: Compounds like 2-[5-[(3-methyl-1-oxo-4H-benzo[f]quinazolin-9-yl)methylamino]-1-oxo-isoindolin-2-yl]pentanedioic acid have shown promise in drug discovery, particularly in the realms of cancer treatment and antibacterial applications. Their ability to interact with specific biological pathways makes them potential candidates for therapeutic agents.
  • Structural Complexity: The molecule features multiple functional groups, which contribute to its unique chemical reactivity. The presence of both isoindolin and quinazoline rings reflects a rich tapestry of organic chemistry that can lead to innovative synthetic pathways.
  • Mechanism of Action: While the exact mechanisms through which this compound operates remain an active area of study, its design allows for the investigation of enzyme inhibition as well as targets in cellular signaling pathways, which are crucial in various diseases.
  • Multi-functional Applications: Beyond medicinal chemistry, such compounds can also serve as research tools in biochemical assays, aiding scientists in understanding metabolic processes and disease mechanisms.
  • Investigation of Derivatives: The unique structure encourages researchers to synthesize and evaluate derivatives, potentially enhancing efficacy and reducing side effects in therapeutic contexts.

In summary, 2-[5-[(3-methyl-1-oxo-4H-benzo[f]quinazolin-9-yl)methylamino]-1-oxo-isoindolin-2-yl]pentanedioic acid represents an exciting frontier in chemical research, exemplifying how intricate molecular design can yield compounds with substantial biological significance. As scientists delve deeper into its characteristics, we can expect to uncover even more about its potential and utility.