Skip to main content

Oxymetazoline

ADVERTISEMENT
Identification
Molecular formula
C16H24N2
CAS number
2315-02-8
IUPAC name
2-[(4-tert-butyl-2,6-dimethyl-phenyl)methyl]-4,5-dihydro-1H-imidazole
State
State

At room temperature, oxymetazoline is typically in the form of a solid powder. In pharmaceutical formulations, it may be found as a solution or suspension, depending on its application.

Melting point (Celsius)
115.00
Melting point (Kelvin)
388.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
260.38g/mol
Molar mass
260.3800g/mol
Density
1.0800g/cm3
Appearence

Oxymetazoline typically appears as a white to yellowish powder. It is usually odorless and can be used in various pharmaceutical formulations.

Comment on solubility

Solubility of 2-[(4-tert-butyl-2,6-dimethyl-phenyl)methyl]-4,5-dihydro-1H-imidazole

The solubility of 2-[(4-tert-butyl-2,6-dimethyl-phenyl)methyl]-4,5-dihydro-1H-imidazole (C16H24N2) can be influenced by various factors, primarily due to its unique structural characteristics.

Key Factors Affecting Solubility:

  • Polarity: The presence of nitrogen atoms within the imidazole ring contributes to some polar characteristics; however, the overall molecule is predominantly hydrophobic due to the bulky tert-butyl and dimethyl groups.
  • Hydrogen Bonding: The potential for hydrogen bonding from the nitrogen atoms can enhance solubility in polar solvents to a limited extent.
  • Temperature: Solubility may increase with temperature, as many organic compounds tend to dissolve better in higher temperatures.
  • pH Levels: The solubility in aqueous environments may vary with pH, affecting the ionization of the nitrogen atoms.

In general, it is expected that this compound exhibits low to moderate solubility in water due to its bulky hydrophobic groups, but it may show better solubility in organic solvents such as ethanol or acetone. As always, empirical testing is necessary to accurately determine solubility in various solvents, since “the devil is in the details” when it comes to predicting the behavior of complex molecular structures.

Interesting facts

Interesting Facts about 2-[(4-tert-butyl-2,6-dimethyl-phenyl)methyl]-4,5-dihydro-1H-imidazole

This compound, with its complex structure, is part of the imidazole family, which are known for their diverse applications in various fields. Here are some intriguing aspects of this chemical:

  • Biodiversity in Pharmacology: Imidazole derivatives have gained attention in medicinal chemistry due to their roles as potential therapeutic agents. This particular compound may exhibit unique biological activity, making it a candidate for further study in drug development.
  • Unique Structural Features: The presence of a tert-butyl group enhances the compound's hydrophobic characteristics, which can influence its interactions with biological membranes. The dimethyl and phenyl groups also play critical roles in determining the compound's reactivity and solubility.
  • Synthetic Pathways: The synthesis of this compound involves intricate reactions that showcase the ingenuity of organic chemistry. Understanding how to construct such a molecule can provide insights into developing new synthetic strategies for other complex organic compounds.
  • Catalytic Applications: Some imidazole-containing compounds are known to serve as ligands in catalysis. This compound could find applications in facilitating chemical reactions, particularly those involving oxidation or coordination processes.

As quoted by renowned chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." This sentiment rings true as researchers explore the diverse roles of compounds like 2-[(4-tert-butyl-2,6-dimethyl-phenyl)methyl]-4,5-dihydro-1H-imidazole in various scientific fields.

Overall, the study of this compound opens the door to many questions and future explorations within organic chemistry, pharmacology, and materials science. It embodies the continuing journey of discovery in the intricate world of chemical compounds.

Synonyms
xylometazoline
526-36-3
Xylomethazoline
Otrivine
Otriven
Otrivin
Otrix
Xilometazolina
2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole
Xylometazolinum
Ba-11391
Balminil
UNII-WPY40FTH8K
WPY40FTH8K
2-(4-tert-Butyl-2,6-dimethylbenzyl)-2-imidazoline
2-(4-(tert-butyl)-2,6-dimethylbenzyl)-4,5-dihydro-1H-imidazole
EINECS 208-390-6
Ba 11391
Xylometazolinum [INN-Latin]
Xilometazolina [INN-Spanish]
BRN 0180524
2-IMIDAZOLINE, 2-(4-tert-BUTYL-2,6-DIMETHYLBENZYL)-
1H-Imidazole, 2-((4-(1,1-dimethylethyl)-2,6-dimethylphenyl)methyl)-4,5-dihydro-
CHEMBL312448
DTXSID8046957
Ba 11391; Otriven; Otrivin
CHEBI:10082
5-23-07-00109 (Beilstein Handbook Reference)
Xylometazoline (INN)
2-(4-tert-Butyl-2,6-dimethylbenzyl)-4,5-dihydro-1H-imidazole
1H-Imidazole, 2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-
XYLOMETAZOLINE [INN]
Xylometazolinum (INN-Latin)
Xilometazolina (INN-Spanish)
Xylometazoline [INN:BAN]
2-(4-tert-Butyl-2,6-dimethyl-benzyl)-4,5-dihydro-1H-imidazole
NCGC00016101-02
CAS-1218-35-5
Balminil (TN)
2-(4'-tert-butyl-2',6'-dimethylphenylmethyl)imidazoline
Spectrum_000382
Prestwick0_000223
Prestwick1_000223
Prestwick2_000223
Prestwick3_000223
Spectrum2_000945
Spectrum3_000586
Spectrum4_000382
Spectrum5_001469
Lopac-X-6000
XYLOMETAZOLINE [MI]
Lopac0_001269
SCHEMBL34087
BSPBio_000265
BSPBio_002032
GTPL517
KBioGR_000903
KBioSS_000862
DivK1c_000158
XYLOMETAZOLINE [VANDF]
SPBio_000910
SPBio_002186
BPBio1_000293
XYLOMETAZOLINE [WHO-DD]
DTXCID6026957
BDBM30703
cid_5282386
HY-B0475A
KBio1_000158
KBio2_000862
KBio2_003430
KBio2_005998
KBio3_001532
R01AA07
R01AB06
S01GA03
NINDS_000158
2-{[4-(tert-butyl)-2,6-dimethylphenyl]methyl}-2-imidazoline
HMS3604M22
s5854
STK558658
AKOS000115430
CCG-205342
DB06694
KS-5071
SDCCGSBI-0051235.P004
2-[[4-(1,1-Dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-1H-imidazole
IDI1_000158
NCGC00016101-01
NCGC00016101-03
NCGC00016101-04
NCGC00016101-05
NCGC00016101-06
NCGC00016101-07
NCGC00016101-09
NCGC00016101-18
NCGC00024281-03
SBI-0051235.P003
DB-052151
CS-0013861
NS00000479
EN300-02385
VU0239751-6
C07913
D08684
G78137
Q31030
AB00053567_11
AB00053567_12
L001171
BRD-K08356259-003-05-6
BRD-K08356259-003-15-5
BRD-K08356259-003-23-9
BRD-K08356259-003-24-7
F1371-0282
2-(4-tert-butyl-2,6-dimethyl-benzyl)-2-imidazoline;hydrochloride
2-(4-tert-Butyl-2,6-dimethylbenzyl)-4,5-dihydro-1H-imidazole #
2-[(4-t-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole
2-[(4-t-butyl-2,6-dimethylphenyl)methyl]4,5dihydro-1H-imidazole
2-[(4-tert-butyl-2,6-dimethyl-phenyl)methyl]-4,5-dihydro-1H-imidazole;hydrochloride
2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole;hydrochloride
208-390-6