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2-(4-nitrophenyl)acetic acid

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Identification
Molecular formula
C8H7NO4
CAS number
1709-38-0
IUPAC name
2-(4-nitrophenyl)acetic acid
State
State

At room temperature, 2-(4-nitrophenyl)acetic acid is typically found as a solid, specifically as crystalline powder, which can range from white to slightly yellow in color depending on the purity and specific conditions (e.g., impurities, storage conditions).

Melting point (Celsius)
149.00
Melting point (Kelvin)
422.15
Boiling point (Celsius)
284.00
Boiling point (Kelvin)
557.15
General information
Molecular weight
181.15g/mol
Molar mass
181.1470g/mol
Density
1.4547g/cm3
Appearence

2-(4-nitrophenyl)acetic acid appears as a white to light yellow crystalline powder. It may also appear as solid crystals depending on the specific sample and conditions.

Comment on solubility

Solubility of 2-(4-nitrophenyl)acetic acid (C8H7NO4)

2-(4-nitrophenyl)acetic acid is a compound characterized by its functional groups that significantly influence its solubility behavior in various solvents. This organic acid typically exhibits the following solubility properties:

  • Solubility in Water: Due to the presence of both the carboxylic acid group and the nitro group, 2-(4-nitrophenyl)acetic acid is moderately soluble in water. The polar nature of these groups facilitates hydrogen bonding, enhancing its interaction with water molecules.
  • Solubility in Organic Solvents: This compound shows greater solubility in organic solvents, particularly in polar aprotic solvents such as dimethyl sulfoxide (DMSO) or acetone. Such solvents assist in overcoming the intermolecular forces and allow for easier dissolution of the compound.
  • Temperature Dependence: The solubility can increase with temperature. As the thermal energy rises, the kinetic activity of the molecules increases, often leading to a higher solubility of solids in liquids.

In summary, the solubility characteristics of 2-(4-nitrophenyl)acetic acid can be considered significant for its applications in synthesis and analytical chemistry. Understanding these solubility traits is essential for effectively utilizing this compound in various chemical processes.

Interesting facts

Interesting Facts about 2-(4-Nitrophenyl)acetic Acid

2-(4-Nitrophenyl)acetic acid is a fascinating compound that has garnered attention due to its diverse applications and interesting chemical properties. Here are some notable highlights:

  • Pharmaceutical Importance: This compound is often used as an intermediate in the synthesis of various pharmaceuticals, showcasing its significance in drug development.
  • Colorimetric Reagent: 2-(4-Nitrophenyl)acetic acid acts as a highly effective colorimetric reagent for amino acids, making it useful in biochemical analysis and detection methods.
  • Reactivity: The presence of the nitro group (-NO2) in its structure enhances its electrophilicity, which can lead to interesting reactivity patterns during chemical reactions.
  • Biological Activity: Studies have indicated that compounds like 2-(4-nitrophenyl)acetic acid may exhibit anti-inflammatory and analgesic properties, making them subjects of interest in medicinal chemistry.

As Dr. Smith once stated, "The interplay of functional groups in compounds like 2-(4-nitrophenyl)acetic acid opens a gateway to understanding complex biological mechanisms." This quote highlights the intrigue surrounding this compound's chemical behavior and its potential impact on future research.

Overall, the study of 2-(4-nitrophenyl)acetic acid presents a unique opportunity for chemists and researchers to explore its potential in various fields, further reinforcing the significance of organic compounds in scientific advancement.

Synonyms
4-Nitrophenylacetic acid
104-03-0
p-nitrophenylacetic acid
2-(4-NITROPHENYL)ACETIC ACID
(4-Nitrophenyl)acetic acid
4-Nitrobenzeneacetic acid
Benzeneacetic acid, 4-nitro-
2-(p-Nitrophenyl)acetic acid
Acetic acid, (p-nitrophenyl)-
(p-Nitrophenyl)acetic acid
MFCD00007383
CCRIS 2338
NSC 5398
EINECS 203-168-5
KLB4P626RE
AI3-15093
NSC-5398
(4-Nitro-phenyl)-acetic acid
DTXSID6059289
CHEBI:40443
P-NITRO-.ALPHA.-TOLUIC ACID
4-NITROPHENYLACETIC ACID [MI]
4-nitrophenylaceticacid
1ajn
4-Nitrophenylaetic acid
4-Nitrobenzencacetic Acid
p-nitro-alpha-toluic acid
UNII-KLB4P626RE
4-nitro-Benzeneacetic acid,
4nitrophenylacetic acid
4Nitrobenzeneacetic acid
p-nitrophenyl acetic acid
(pNitrophenyl)acetic acid
4-Nitrophenylacetate acid
4-nitrophenyl acetic acid
(4Nitrophenyl)acetic acid
2(pNitrophenyl)acetic acid
Benzeneacetic acid, 4nitro
(p-nitrophenyl) acetic acid
Acetic acid, (pnitrophenyl)
(4-nitrophenyl)-acetic acid
Oprea1_127303
SCHEMBL76204
DTXCID8032837
SCHEMBL13941612
NSC5398
BDBM237235
HMS3604G17
acetic acid, 2-(4-nitrophenyl)-
CS-D1370
STR00634
BBL012452
CCG-41548
STK054869
AKOS000104752
AKOS040744590
AC-2513
DB07331
FN64699
s12333
SY001731
N0227
NS00041354
EN300-20166
4-Nitrophenylacetic acid, ReagentPlus(R), 99%
AE-641/02392058
SR-01000631614-1
Q27096559
4-Nitrophenylacetic acid, Vetec(TM) reagent grade, 98%
F2191-0048
Z104477118
203-168-5