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Thiamine pyrophosphate

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Identification
Molecular formula
C8H16N2O7P2
CAS number
154-87-0
IUPAC name
2-(4-methylthiazol-5-yl)ethyl dihydrogen phosphate
State
State

At room temperature, thiamine pyrophosphate is usually in a solid state. It is a stable compound but should be handled with care as it may degrade if exposed to excessive heat or light.

Melting point (Celsius)
248.00
Melting point (Kelvin)
521.15
Boiling point (Celsius)
236.00
Boiling point (Kelvin)
509.15
General information
Molecular weight
246.22g/mol
Molar mass
242.2320g/mol
Density
1.4400g/cm3
Appearence

The compound typically appears as colorless to pale yellow crystals. It may also be available in powdered form, often displaying a shiny and slightly oily appearance due to the crystalline nature.

Comment on solubility

Solubility of 2-(4-methylthiazol-5-yl)ethyl dihydrogen phosphate

The solubility of 2-(4-methylthiazol-5-yl)ethyl dihydrogen phosphate (C8H16N2O7P2) can be determined by examining its molecular structure and functional groups. This compound features a phosphate group, which is typically associated with increased solubility in polar solvents due to its ability to form hydrogen bonds.

Here are some key points regarding its solubility:

  • Polar Nature: The presence of the dihydrogen phosphate group suggests that the compound is likely to be soluble in water, a polar solvent.
  • Hydrogen Bonding: The ability of the phosphate group to interact with water through hydrogen bonding further enhances solubility.
  • Effect of Substituents: The 4-methylthiazol group, while hydrophobic, can still contribute to solubility through its electron-donating characteristics, depending on the overall balance of hydrophilic and hydrophobic interactions.

In conclusion, while the specific solubility data for 2-(4-methylthiazol-5-yl)ethyl dihydrogen phosphate is not extensively reported, its structural motifs suggest that it is likely to exhibit a reasonably good solubility in aqueous environments. Further experimental evaluation is warranted to ascertain exact solubility values and behavior in various solvents.

Interesting facts

Interesting Facts about 2-(4-methylthiazol-5-yl)ethyl dihydrogen phosphate

2-(4-methylthiazol-5-yl)ethyl dihydrogen phosphate is a fascinating compound that plays an essential role in the field of biochemistry and pharmaceuticals. Here are some key points regarding this intriguing molecule:

  • Biological Significance: This compound contains a thiazole ring, which is a common structural motif found in numerous biological molecules, including vitamins and coenzymes. The presence of the thiazole group suggests potential bioactive properties.
  • Applications in Research: Dihydrogen phosphates like this compound are often used in enzyme assays and as substrates in biochemical research. They can help in studying enzyme kinetics and the mechanism of action of various biochemical pathways.
  • Pharmacological Potential: Compounds that contain dihydrogen phosphate moieties are of interest in drug design due to their potential activity against a variety of targets. This makes them promising candidates for further pharmaceutical development.
  • Structural Diversity: The combination of the thiazole ring and the phosphate group in this compound creates a rich structural diversity that can lead to various derivatives, each with unique biological activities.
  • Conformational Flexibility: The ethyl chain in this molecule adds to its flexibility, potentially influencing its interactions with enzymes and biological targets, which is crucial for binding and activity.

Understanding the properties and behaviors of 2-(4-methylthiazol-5-yl)ethyl dihydrogen phosphate not only aids in the advancement of medicinal chemistry but also opens new avenues for therapeutic applications, showcasing the importance of exploring complex compounds in the realm of science.

Synonyms
4-METHYL-5-HYDROXYETHYLTHIAZOLE PHOSPHATE
2-(4-methyl-1,3-thiazol-5-yl)ethyl dihydrogen phosphate
4-methyl-5-(2-phosphonooxyethyl)thiazole
NIOSH/XJ4673300
4-Methyl-5-thiazoleethanol phosphate
3269-79-2
5-Thiazoleethanol, 4-methyl-, phosphate
XJ46733000
HET-P
4-Methyl-5-(2-phosphooxyethyl)thiazole
SCHEMBL459428
CHEBI:17857
DTXSID701209634
DB03145
PD007347
4-Methyl-5-(2-phosphono-oxyethyl)-thiazole
NS00068536
5-(2-hydroxyethyl)-4-methylthiazole phosphate
C04327
Q61014521
5-Thiazoleethanol, 4-methyl-, 5-(dihydrogen phosphate)