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2-(4-Methylpiperazin-1-yl)quinoline

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Identification
Molecular formula
C14H17N3
CAS number
39546-32-2
IUPAC name
2-(4-methylpiperazin-1-yl)quinoline
State
State

At room temperature, 2-(4-Methylpiperazin-1-yl)quinoline is typically in a solid state. It is stable under standard conditions, retaining its solid form.

Melting point (Celsius)
126.00
Melting point (Kelvin)
399.15
Boiling point (Celsius)
410.60
Boiling point (Kelvin)
683.80
General information
Molecular weight
227.32g/mol
Molar mass
227.3180g/mol
Density
1.1740g/cm3
Appearence

2-(4-Methylpiperazin-1-yl)quinoline appears as a crystalline solid. It tends to have a white to off-white color, appearing fairly uniform throughout.

Comment on solubility

Solubility of 2-(4-methylpiperazin-1-yl)quinoline

The solubility of the compound 2-(4-methylpiperazin-1-yl)quinoline, with the chemical formula C14H17N3, plays a crucial role in its practical applications, particularly in pharmaceutical formulations. Understanding its solubility characteristics can help predict its behavior in various solvents.

Key Points on Solubility:

  • Polar vs. Non-Polar Solvents: This compound's solubility may vary significantly between polar and non-polar solvents due to its aromatic structure and the amine functional groups present.
  • Temperature Dependency: The solubility is likely to change with temperature; typically, an increase in temperature enhances solubility in most organic solvents.
  • pH Influence: The solubility can also be affected by the pH of the solution, particularly because the nitrogen in the piperazine ring can accept protons, potentially enhancing solubility in acidic conditions.

As a general observation, compounds like 2-(4-methylpiperazin-1-yl)quinoline often demonstrate a solubility profile that is
*higher in organic solvents* and *lower in water*, which is common for many aromatic amines. As such, conducting experiments under varying conditions will provide a clearer understanding of this compound’s solubility.

Interesting facts

Exploring 2-(4-Methylpiperazin-1-yl)quinoline

2-(4-Methylpiperazin-1-yl)quinoline is an intriguing compound that merges the structural features of both quinoline and piperazine moieties, showcasing a variety of fascinating attributes. Here are some key insights into this remarkable compound:

  • Pharmacological Significance: Compounds with a quinoline backbone are recognized for their biological activities, including their roles as antibacterial, antimalarial, and anti-inflammatory agents. The presence of the piperazine group enhances the pharmacological profile, making this compound a candidate for drug development.
  • Versatile Applications: Beyond medicinal chemistry, 2-(4-Methylpiperazin-1-yl)quinoline may find use in the field of materials science. Its ability to interact with various biological substrates can lead to innovative applications in biochemistry and nanotechnology.
  • Structure-Activity Relationship: Chemists are particularly interested in the structural diversity of quinoline derivatives. 2-(4-Methylpiperazin-1-yl)quinoline's unique molecular structure allows researchers to study how modifications can affect its pharmacological activity, providing insight into structure-activity relationships (SAR).
  • Synthesis and Modifications: The synthetic pathways to create this compound often involve multi-step reactions, showcasing the challenge and creativity required in organic synthesis. This provides opportunities for chemistry students to engage in practical learning experiences.
  • Research Potential: With ongoing studies evaluating the therapeutic potential of various quinoline derivatives, 2-(4-Methylpiperazin-1-yl)quinoline remains an exciting subject for current and future research endeavors. Scientists are continually investigating its properties and exploring new derivatives for enhanced efficacy.

In conclusion, 2-(4-Methylpiperazin-1-yl)quinoline stands as an example of the rich interplay between structure and function in chemical compounds. Its role in pharmaceutical research, combined with its intriguing synthetic pathways, makes it a captivating topic for both seasoned chemists and emerging students in the field.

Synonyms
N-methylquipazine
2-(4-methylpiperazin-1-yl)quinoline
28614-26-8
quinoline, 2-(4-methyl-1-piperazinyl)-
0YV1ZIR6S0
CHEMBL288591
CHEBI:64164
1-(2-Quinolyl)-4-methylpiperazine
J366.838J
2-(4-Methyl-piperazin-1-yl)-quinoline
2-(1-(4-methyl)-piperazinyl)quinoline
Tocris-0566
Lopac-Q-107
Biomol-NT_000084
UNII-0YV1ZIR6S0
Lopac0_001000
Oprea1_654246
SCHEMBL606721
BPBio1_001081
DTXSID8043731
HOMWNUXPSJQSSU-UHFFFAOYSA-N
2-(4-Methylpiperazinyl)-quinoline
BDBM50053631
STK362919
AKOS005453926
CCG-205080
NCGC00015867-01
NCGC00015867-02
NCGC00015867-03
NCGC00015867-04
NCGC00024653-01
NCGC00024653-02
NCGC00024653-03
EN300-14327696
BRD-K62056274-001-01-9
BRD-K62056274-332-01-8
Q27133086
Z31193883