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Phenazone

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Identification
Molecular formula
C20H13ClFN3O
CAS number
60-80-0
IUPAC name
2-(4-chlorophenyl)-4-(4-fluorophenyl)-5-(4-pyridyl)-1H-pyrazol-3-one
State
State

At room temperature, Phenazone is typically a solid. It forms stable crystals and maintains its structure well under standard conditions.

Melting point (Celsius)
156.00
Melting point (Kelvin)
429.00
Boiling point (Celsius)
514.50
Boiling point (Kelvin)
787.70
General information
Molecular weight
308.76g/mol
Molar mass
308.7610g/mol
Density
1.3440g/cm3
Appearence

Phenazone appears as a crystalline powder that is usually white or slightly yellow in color. It has a characteristic odor and is soluble in alcohol and chloroform. Under normal lighting, its crystalline structure can be observed with greater detail.

Comment on solubility

Solubility of 2-(4-chlorophenyl)-4-(4-fluorophenyl)-5-(4-pyridyl)-1H-pyrazol-3-one

The solubility of the compound C20H13ClFN3O, known as 2-(4-chlorophenyl)-4-(4-fluorophenyl)-5-(4-pyridyl)-1H-pyrazol-3-one, may be influenced by various factors. Understanding its solubility characteristics is essential for applications in pharmaceuticals, agrochemicals, and materials science.

Key Factors Affecting Solubility:

  • Molecular Structure: The presence of halogens (chlorine and fluorine) and the pyridine ring can impact the compound's polarity, thus affecting its solubility in different solvents.
  • Solvent Type: This compound may exhibit varying solubility in polar versus non-polar solvents. Generally, compounds with significant polar characteristics are more soluble in polar solvents.
  • Temperature: Like many organic compounds, solubility can increase with temperature, which allows for greater molecular movement and interaction with solvents.

In practice, you might find that this compound is:

  • Partially soluble in organic solvents like ethanol or dimethyl sulfoxide (DMSO).
  • Less soluble in water due to its hydrophobic regions stemming from aromatic substituents.

When conducting experiments, it is always advisable to perform solubility tests at controlled temperatures and in various solvents to better understand its behavior. Quotes from researchers often emphasize the importance of rigor in solubility assessment: “The solubility profile of any new drug candidate is a crucial parameter that can dictate its pharmacokinetic properties.” Thus, comprehending the solubility of C20H13ClFN3O can greatly inform its practical applications.

Interesting facts

Exploring 2-(4-chlorophenyl)-4-(4-fluorophenyl)-5-(4-pyridyl)-1H-pyrazol-3-one

2-(4-chlorophenyl)-4-(4-fluorophenyl)-5-(4-pyridyl)-1H-pyrazol-3-one is a fascinating compound that belongs to the pyrazolone class of organic compounds. This compound has garnered attention due to its potential pharmaceutical applications and interesting structural features.

Notable Characteristics:

  • Diverse Substituents: The presence of chlorine, fluorine, and pyridyl groups makes this compound particularly intriguing. These substituents can influence the compound's reactivity and biological properties.
  • Pharmacological Potential: Compounds like this one are being studied for their potential as anti-inflammatory agents, analgesics, and even as antitumor agents. The presence of the pyrazol-3-one core is often associated with various pharmacological activities.
  • Structure-Activity Relationship: The modification of substituents can lead to significant changes in activity. Understanding how these different groups affect the overall behavior of the compound is vital for developing effective drugs.
  • Research Applications: This compound can serve as a model structure in studying drug interactions, mechanisms of action, and the development of new therapeutic agents.

As scientists delve deeper into compounds like 2-(4-chlorophenyl)-4-(4-fluorophenyl)-5-(4-pyridyl)-1H-pyrazol-3-one, they open up a world of possibilities that bridge chemistry and biology. The ongoing research not only highlights the utility of pyrazolones but also emphasizes the importance of targeted molecular design in drug discovery.

In the words of chemist Linus Pauling, “The secret of getting results from your experiments is to be entirely sincere.” The exploration of compounds like this one echoes the principle of sincerity in research, as scientists strive for accurate representation of molecular interactions and potential benefits.

Synonyms
p38 MAP Kinase Inhibitor
219138-24-6
p38 MAPK Inhibitor
p38 MAPK-IN-4
2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1,2-dihydropyrazol-3-one
2-(4-chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1H-pyrazol-3-one
CHEMBL91730
2-(4-chlorophenyl)-4-(4-fluorophenyl)-5-(pyridin-4-yl)-1,2-dihydro-3h-pyrazol-3-one
compound 6 [PMID: 9873604]
SCHEMBL284480
35PZD2YS67
CHEMBL408678
GTPL6013
HMS3229M06
BDBM50071907
EX-A11785
AKOS040754984
CCG-206872
SDCCGSBI-0086778.P003
DA-56538
TS-08844
HY-112466
CS-0046093
G67555
Q27088229
2-(4-Chloro-phenyl)-4-(4-fluoro-phenyl)-5-pyridin-4-yl-1,2-dihydro-pyrazol-3-one
2-(4-chlorophenyl)-4-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydro-1H-pyrazol-3-one
2-(4-CHLOROPHENYL)-4-(4-FLUOROPHENYL)-1,2-DIHYDRO-5-(4-PYRIDINYL)-3H-PYRAZOL-3-ONE
3H-PYRAZOL-3-ONE, 2-(4-CHLOROPHENYL)-4-(4-FLUOROPHENYL)-1,2-DIHYDRO-5-(4-PYRIDINYL)-