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Clomiphene

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Identification
Molecular formula
C26H28ClNO
CAS number
50-41-9
IUPAC name
2-(4-chlorophenyl)-1-[4-[2-(diethylamino)ethoxy]phenyl]-1-(p-tolyl)ethanol
State
State

Clomiphene is typically found in a solid state at room temperature.

Melting point (Celsius)
116.50
Melting point (Kelvin)
389.60
Boiling point (Celsius)
493.30
Boiling point (Kelvin)
766.50
General information
Molecular weight
405.97g/mol
Molar mass
405.9660g/mol
Density
1.0648g/cm3
Appearence

Clomiphene appears as a fine white to pale yellow powder.

Comment on solubility

Solubility of 2-(4-chlorophenyl)-1-[4-[2-(diethylamino)ethoxy]phenyl]-1-(p-tolyl)ethanol

The solubility of 2-(4-chlorophenyl)-1-[4-[2-(diethylamino)ethoxy]phenyl]-1-(p-tolyl)ethanol in various solvents can be quite intriguing due to its complex structure. Given its composition, we can make some general observations:

  • Polar Solvents: The presence of the diethylamino and ethoxy groups suggests that this compound may exhibit solubility in polar solvents such as water and methanol to some extent, although it is likely to be limited due to the bulky aromatic groups.
  • Non-Polar Solvents: Considering the large hydrophobic aromatic components, this compound may show increased solubility in non-polar solvents like toluene or chloroform.
  • Temperature Effects: Solubility can be influenced by temperature; generally, higher temperatures improve solubility for most compounds.

As a result, it is important to note that the solubility of such a compound can vary significantly depending on the solvent used and the conditions applied. In practice, predicting the solubility profile requires empirical testing. As noted in chemical literature, "solubility is key for understanding the behavior of a compound in biological systems." Thus, the study of its solubility is essential, particularly for applications involving pharmacology or materials science.

Interesting facts

Interesting Facts about 2-(4-chlorophenyl)-1-[4-[2-(diethylamino)ethoxy]phenyl]-1-(p-tolyl)ethanol

This compound is intriguing not just for its complex structure but also for its potential applications in various fields. Here are some fascinating aspects of this compound:

  • Pharmaceutical Relevance: The molecular design hints at possible uses in the pharmaceutical industry, particularly due to the presence of the diethylamino group, which is known to enhance bioactivity.
  • Structural Diversity: With multiple aromatic rings and functional groups, the compound displays structural diversity that can influence its reactivity and interactions with biological targets.
  • Synthetic Interest: Chemists are often drawn to synthesize such compounds to explore reaction pathways, study mechanisms, or develop novel analogs with improved efficacy.
  • Potential Mechanism Insights: The inclusion of an ethoxy group suggests that the compound may exhibit interesting properties related to solubility and pharmacokinetics, potentially affecting how it interacts within biological systems.
  • Research Opportunities: This compound could serve as a template for further research studies, exploring variations in its structure to fine-tune its pharmacological properties.
  • Defining Therapeutic Pathways: Investigation into the therapeutic pathways influenced by similar compounds may illuminate new directions for drug discovery.

In summary, 2-(4-chlorophenyl)-1-[4-[2-(diethylamino)ethoxy]phenyl]-1-(p-tolyl)ethanol represents a rich chemical ensemble that challenges chemists and pharmacologists alike to dissect its properties and unleash its potential in advancing medicinal chemistry.

Synonyms
TRIPARANOL
78-41-1
Metasqualene
triparanolum
valip
Metasclene
Clotrox
MER 29
Hipocolestina
Triparanolo
Acosterina
Diticyl
Drenaren
Trianel
Triparanolo [DCIT]
Triparin
Tropalin
Triparanol [INN:BAN]
Triparanolum [INN-Latin]
Trikosterol
Verdiana
Sclane
2-p-Chlorophenyl-1-(p-(2-diethylaminoethoxy)phenyl)-1-p-tolylethanol
EINECS 201-115-0
63S8C3RXGS
NSC 65345
NSC-65345
BRN 2064866
DTXSID6046507
TRIPARANOL [MI]
MER-2p
TRIPARANOL [INN]
TRIPARANOL [WHO-DD]
1-(4-(2-(Diethylamino)ethoxy)phenyl)-1-(p-tolyl)-2-(p-chlorophenyl)ethanol
Benzeneethanol, 4-chloro-alpha-(4-(2-(diethylamino)ethoxy)phenyl)-alpha-(4-methylphenyl)-
CHEMBL187709
DTXCID4026507
alpha-(p-Chlorobenzyl)-4-diethylaminoethoxy-4'-methylbenzhydrol
1-(4-(2-Diethylaminoethoxy)phenyl)-1-p-tolyl-2-(4-chlorophenyl)ethanol
1-(p-(beta-Diethylaminoethoxy)phenyl)-1-(p-tolyl)-2-(p-chlorophenyl)ethanol
2-(p-Chlorophenyl)-1-(p-(beta-diethylaminoethoxy)phenyl)-1-(p-tolyl)ethanol
Ethanol, 2-(p-chlorophenyl)-1-(p-(2-(diethylamino)ethoxy)phenyl)-1-p-tolyl-
NCGC00165907-02
.alpha.-(p-Chlorobenzyl)-4-diethylaminoethoxy-4'-methylbenzhydrol
Triparanolum (INN-Latin)
Benzeneethanol, 4-chloro-.alpha.-[4-[2-(diethylamino)ethoxy]phenyl]-.alpha.-(4-methylphenyl)-
1-[4-[2-(Diethylamino)ethoxy]phenyl]-1-(p-tolyl)-2-(p-chlorophenyl)ethanol
2-(4-chlorophenyl)-1-[4-[2-(diethylamino)ethoxy]phenyl]-1-(p-tolyl)ethanol
1-(p-(.beta.-Diethylaminoethoxy)phenyl)-1-(p-tolyl)-2-(p-chlorophenyl)ethanol
2-(p-Chlorophenyl)-1-(p-(.beta.-diethylaminoethoxy)phenyl)-1-(p-tolyl)ethanol
CAS-78-41-1
UNII-63S8C3RXGS
2-p-Chlorophenyl-1-[p-(2-diethylaminoethoxy)phenyl]-1-p-tolylethanol
1-[p-(.beta.-Diethylaminoethoxy)phenyl]-1-(p-tolyl)-2-(p-chlorophenyl)ethanol
2-(4-chlorophenyl)-1-(4-(2-(diethylamino)ethoxy)phenyl)-1-(p-tolyl)ethanol
2-(p-Chlorophenyl)-1-[p-(.beta.-diethylaminoethoxy)phenyl]-1-(p-tolyl)ethanol
Ethanol, 2-(p-chlorophenyl)-1-(p-[2-(diethylamino)ethoxy]phenyl)-1-p-tolyl-
Ethanol, 2-(p-chlorophenyl)-1-[p-[2-(diethylamino)ethoxy]phenyl]-1-p-tolyl-
2-(4-chlorophenyl)-1-[4-[2-(diethylamino)ethoxy]phenyl]-1-(4-methylphenyl)ethanol
SCHEMBL133384
CHEBI:135714
NSC65345
Tox21_112268
BDBM50170637
MFCD00865748
AKOS040747553
Tox21_112268_1
Triparanol, >=97% (HPLC), powder
FT28574
NCGC00165907-01
NCGC00165907-03
WLN: GR D1XQR D1&R DO2N2&2
TS-08460
NS00037986
SR-01000944816
Q5988254
SR-01000944816-1
2-(4-Chloro-phenyl)-1-[4-(2-diethylamino-ethoxy)-phenyl]-1-p-tolyl-ethanol
1-(p-(.beta.-Diethylaminoethoxy)phenyl)-1-(p-tolyl)-2-(p-chlorophenyl)ethanol 1,3-Propanediol, 2-methyl-
201-115-0
4-Chloro-a-[4-[2-(diethylamino)ethoxy]phenyl]-a-(4-methylphenyl)benzeneethanol;1-[4-[2-(Diethylamino)ethoxy]phenyl]-1-(p-tolyl)-2-(p -chlorophenyl)ethanol
Benzeneethanol, 4-chloro-alpha-(4-(2-(diethylamino)ethoxy)phenyl)-alpha-(4-methylphenyl)-(9CI)