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Teicoplanin A2

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Identification
Molecular formula
C88H97Cl2N9O36
CAS number
61036-62-2
IUPAC name
2-[[4-carboxy-4-[2-[hydroxy-[2,3,4-trihydroxy-5-(8-hydroxy-2,4-dioxo-1,5,5a,6,7,8,9,9a-octahydropyrimido[4,5-b]quinolin-10-yl)pentoxy]phosphoryl]oxypropanoylamino]butanoyl]amino]pentanedioic acid
State
State

At room temperature, teicoplanin A2 is typically in a solid state as a crystalline powder. It is utilized as an antibiotic and thus often stored under specific conditions to maintain its stability and efficacy.

Melting point (Celsius)
208.00
Melting point (Kelvin)
481.00
Boiling point (Celsius)
800.00
Boiling point (Kelvin)
1 073.00
General information
Molecular weight
1879.65g/mol
Molar mass
1 879.6520g/mol
Density
1.6970g/cm3
Appearence

Teicoplanin A2 is a white to off-white powder. It is often found in a crystalline form and is highly soluble in water. Its appearance is very similar to other glycopeptide antibiotics, with a complex structure that reflects its intricate synthesis rooted in natural sources.

Comment on solubility

Solubility of 2-[[4-carboxy-4-[2-[hydroxy-[2,3,4-trihydroxy-5-(8-hydroxy-2,4-dioxo-1,5,5a,6,7,8,9,9a-octahydropyrimido[4,5-b]quinolin-10-yl)pentoxy]phosphoryl]oxypropanoylamino]butanoyl]amino]pentanedioic acid

The solubility of the compound C88H97Cl2N9O36 is influenced by its complex structure, which includes multiple polar functional groups. Soluble compounds typically demonstrate improved interaction with solvents due to their ability to engage in hydrogen bonding and ionic interactions. For this compound, the following aspects are noteworthy:

  • Hydrophilicity: The presence of multiple hydroxyl groups (–OH) suggests a strong affinity for water, enhancing its solubility in polar solvents.
  • Complexity: The large molecular structure may lead to varying solubility profiles, depending on the solvent used. In general, larger and more complex molecules can have lower solubility in simple solvents.
  • pH Sensitivity: Given that the compound includes carboxylic acid moieties, its solubility may significantly change with variations in pH. This is crucial because these groups may deprotonate in basic conditions, increasing solubility.
  • Interactions with Other Components: The presence of functional groups may allow for complex formations with ions or other molecules, further influencing solubility.

In summary, while the compound exhibits potential solubility in polar solvents due to its hydroxyl and carboxylic acid groups, its overall solubility behavior is complex and context-dependent. Further experimental evaluation is necessary to delineate its solubility under specific conditions and in various solvents.

Interesting facts

Interesting Facts about 2-[[4-carboxy-4-[2-[hydroxy-[2,3,4-trihydroxy-5-(8-hydroxy-2,4-dioxo-1,5,5a,6,7,8,9,9a-octahydropyrimido[4,5-b]quinolin-10-yl)pentoxy]phosphoryl]oxypropanoylamino]butanoyl]amino]pentanedioic acid

This compound, often referred to for its intricate structure, represents a fascinating intersection of medicinal chemistry and biochemistry. Here are some intriguing aspects:

  • Complex Structure: The compound features multiple functional groups and heterocycles, including a unique octahydropyrimidoquinoline moiety, making it a subject of interest for synthetic organic chemists aiming to explore complex natural products.
  • Pharmacological Potential: The presence of hydroxyl and carboxyl groups suggests potential *biological activity*. Compounds with similar structural motifs are often screened for their ability to interact with biological targets, hinting at *antimicrobial* or *anticancer* properties.
  • Phosphorylation: The phosphoryl group in the compound is a key feature. Phosphorylated compounds are vital in cellular signaling and metabolism, which can lead to significant implications in drug design.
  • Synthetic Challenges: The synthesis of such a multi-functional compound poses substantial challenges, requiring advanced techniques in organic synthesis and purification methodologies, as the process may involve numerous reaction steps and purification stages.
  • Future Applications: Scientists speculate that compounds with similar backbones may serve as promising candidates in *targeted drug delivery* systems or as *biomaterials* due to their complex architecture and potential bioactivity.

In summary, 2-[[4-carboxy-4-[2-[hydroxy-[2,3,4-trihydroxy-5-(8-hydroxy-2,4-dioxo-1,5,5a,6,7,8,9,9a-octahydropyrimido[4,5-b]quinolin-10-yl)pentoxy]phosphoryl]oxypropanoylamino]butanoyl]amino]pentanedioic acid encapsulates a unique blend of complexity and potential, making it a noteworthy subject for ongoing research in the fields of chemistry and pharmacology.