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2-(4-Butoxyphenyl)ethanehydroxamic acid

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Identification
Molecular formula
C12H17NO3
CAS number
1123-70-4
IUPAC name
2-(4-butoxyphenyl)ethanehydroxamic acid
State
State

At room temperature, 2-(4-Butoxyphenyl)ethanehydroxamic acid is in a solid state, usually in the form of powdery crystals. This is typical for organic compounds of similar molecular mass and complexity.

Melting point (Celsius)
125.00
Melting point (Kelvin)
398.15
Boiling point (Celsius)
321.00
Boiling point (Kelvin)
594.15
General information
Molecular weight
251.32g/mol
Molar mass
251.3220g/mol
Density
1.1200g/cm3
Appearence

2-(4-Butoxyphenyl)ethanehydroxamic acid is typically a crystalline solid. The compound is most commonly found in a white to off-white powder form. This appearance might vary slightly due to impurities or different crystalline structures.

Comment on solubility

Solubility of 2-(4-butoxyphenyl)ethanehydroxamic acid

2-(4-butoxyphenyl)ethanehydroxamic acid, with the chemical formula C12H17NO3, exhibits unique solubility characteristics that are essential for its potential applications. Understanding its solubility profile can aid in various chemical processes:

  • Polar vs. Nonpolar: This compound features a hydroxamic acid group, which is polar due to the presence of the -OH group. This can lead to better solubility in polar solvents, such as water.
  • Hydrophobic Interactions: The butoxy (C4H9O) group, being hydrophobic, may decrease solubility in polar solvents. Therefore, a careful balance exists between the polar hydroxamic group and the nonpolar butoxy group.
  • Solvent Selection: Optimal solubility is often achieved in mixed solvents. For example, it may dissolve better in a combination of alcohols and water rather than in pure water.

In conclusion, the solubility of 2-(4-butoxyphenyl)ethanehydroxamic acid is a nuanced interplay between its polar and nonpolar functional groups. As always, the specific conditions—including temperature, pH, and the presence of other solutes—play a crucial role, which should be considered for practical applications.

Interesting facts

Interesting Facts about 2-(4-butoxyphenyl)ethanehydroxamic acid

2-(4-butoxyphenyl)ethanehydroxamic acid is a fascinating compound with a range of interesting characteristics and applications. Here are some noteworthy points about this compound:

  • Role in Medicinal Chemistry: This compound is part of the hydroxamic acid family, which is known for its ability to inhibit metalloproteinases, enzymes that play a significant role in tissue remodeling. As a result, it has potential applications in treating various diseases, including cancer.
  • Structure and Function: The unique structure of 2-(4-butoxyphenyl)ethanehydroxamic acid allows it to interact with biological targets effectively. It features both a butoxy group, which enhances lipophilicity, and a hydroxamic acid moiety, recognized for its binding ability to metal ions.
  • Versatile Applications: Beyond medicinal chemistry, hydroxamic acids have been studied for their use as metal chelators in industrial applications, catalysis, and even in agriculture to enhance nutrient uptake in plants.
  • Analytical Techniques: Scientists often employ various analytical methods to study this compound, including NMR spectroscopy, mass spectrometry, and X-ray crystallography. These techniques help elucidate its structure and behavior in different environments.
  • Research Interest: The ongoing research into hydroxamic acids, specifically 2-(4-butoxyphenyl)ethanehydroxamic acid, contributes to our understanding of enzymatic activity and how we can innovate novel therapeutic agents.

The exploration of compounds like 2-(4-butoxyphenyl)ethanehydroxamic acid opens up exciting possibilities in drug discovery and biochemical research, emphasizing the importance of studying these unique structures for future advancements in the field of chemistry.

Synonyms
bufexamac
2438-72-4
Bufexamic acid
2-(4-Butoxyphenyl)-N-hydroxyacetamide
Parfenac
Bufexamaco
Norfemac
Paraderm
Parfenal
Anderm
Feximac
Mofenar
Bufexamacum
4-Butoxy-N-hydroxybenzeneacetamide
Droxaryl
Flogicid
Malipuran
p-Butoxyphenylacetohydroxamic acid
4-Butoxyphenylacetohydroxamic acid
Flogocid N plastigel
2-(p-Butoxyphenyl)-acetohydroxamic acid
Acide p-butoxyphenylacethydroxamique
Bufessamac [DCIT]
Bufessamac
Benzeneacetamide, 4-butoxy-N-hydroxy-
CP 1044 J3
Bufexamacum [INN-Latin]
Bufexamaco [INN-Spanish]
2-(p-Butoxyphenyl)acetohydroxamic acid
CP 1044
CHEBI:31317
Bufexamac [INN:BAN:DCF:JAN]
EINECS 219-451-1
CP-1044-J3
NSC-758153
Anderm (TN)
BRN 2646848
ACETOHYDROXAMIC ACID, 2-(p-BUTOXYPHENYL)-
DTXSID7045368
4T3C38J78L
Acide p-butoxyphenylacethydroxamique [French]
BUFEXAMAC [INN]
BUFEXAMAC [JAN]
BUFEXAMAC [MART.]
BUFEXAMAC [WHO-DD]
Butoxyphenylacethydroxamic Acid
CHEMBL94394
MLS000028409
BUFEXAMAC [EP IMPURITY]
BUFEXAMAC [EP MONOGRAPH]
DTXCID5025368
NSC 758153
J3
NCGC00016611-01
SMR000058407
CAS-2438-72-4
Bufexamacum (INN-Latin)
Bufexamaco (INN-Spanish)
BUFEXAMAC (MART.)
BUFEXAMAC (EP IMPURITY)
BUFEXAMAC (EP MONOGRAPH)
Droxarol
ML392
p-Butoxyphenylacethydroxamic Acid
SR-01000003067
2-(4-butoxyphenyl)acetohydroxamic acid
UNII-4T3C38J78L
p Butoxyphenylacethydroxamic Acid
Bufexamac,(S)
Prestwick_676
Bufexamac (Standard)
Spectrum_001754
Bufexamac (JAN/INN)
Opera_ID_1503
Prestwick0_000243
Prestwick1_000243
Prestwick2_000243
Prestwick3_000243
Spectrum2_001457
Spectrum3_000938
Spectrum4_001037
Spectrum5_001117
Epitope ID:180855
cid_2466
REGID_for_CID_2466
SCHEMBL25215
BSPBio_000026
KBioGR_001593
KBioSS_002234
MLS001148632
Bufexamac, analytical standard
DivK1c_000108
SPECTRUM1502003
SPBio_001353
SPBio_002245
BPBio1_000030
GTPL7498
HMS500F10
HY-B0494R
KBio1_000108
KBio2_002234
KBio2_004802
KBio2_007370
KBio3_001976
M01AB17
M02AA09
NINDS_000108
HMS1568B08
HMS1921B18
HMS2095B08
HMS2235I13
HMS3371K16
HMS3656H16
HMS3712B08
HMS3885K03
KUC105648N
Pharmakon1600-01502003
HY-B0494
Para-butoxyphenylacetohydroxamic acid
Tox21_110522
BDBM50015144
CCG-39191
MFCD00078936
NSC758153
s3023
Bufexamac 1.0 mg/ml in Acetonitrile
AKOS015895401
KUC105648N-02
KUC105648N-03
Tox21_110522_1
DB13346
KSC-10-210
IDI1_000108
KSC-390-003
NCGC00016611-02
NCGC00016611-03
NCGC00016611-04
NCGC00016611-05
NCGC00016611-06
NCGC00016611-07
NCGC00016611-09
NCGC00016611-10
NCGC00021813-03
NCGC00021813-04
2-(4-Butoxy-phenyl)-N-hydroxy-acetamide
2-(4-Butoxyphenyl)-N-hydroxyacetamide #
AC-18729
AS-12207
2-(4-Butyloxyphenyl)-N-hydroxy acetamide
KSC-285-073-1
SBI-0051694.P002
AB00052252
B4179
Benzeneacetamide, 4-butoxy-N-hydroxy-(9CI)
NS00000614
SW196831-3
C74254
D01271
AB00052252_19
AB00052252_20
EN300-11686917
Q412699
SR-01000003067-3
SR-01000003067-4
BRD-K36660044-001-15-0
BRD-K36660044-001-23-4
BRD-K36660044-001-24-2
Bufexamac, European Pharmacopoeia (EP) Reference Standard
219-451-1
A4Z