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Cladribine

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Identification
Molecular formula
C10H12ClN5O3
CAS number
4291-63-8
IUPAC name
2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
State
State

At room temperature, cladribine is in a solid state. It is typically handled and stored as a powdery solid.

Melting point (Celsius)
208.00
Melting point (Kelvin)
481.15
Boiling point (Celsius)
848.00
Boiling point (Kelvin)
1 121.15
General information
Molecular weight
285.69g/mol
Molar mass
285.7170g/mol
Density
3.0908g/cm3
Appearence

Cladribine typically appears as a white to off-white crystalline powder. It is odorless and hygroscopic, meaning it can absorb moisture from the air.

Comment on solubility

Solubility of 2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

The solubility of the compound with the formula C10H12ClN5O3 can be quite intriguing due to the presence of several functional groups. Understanding its solubility can provide insights into its behavior in various environments. Below are some key points regarding its solubility:

  • Polarity: The presence of hydroxymethyl (-CH2OH) and amino (-NH2) groups suggests that this compound may be polar in nature. Polar compounds tend to have higher solubility in polar solvents such as water.
  • Hydrogen Bonding: The functional groups capable of forming hydrogen bonds can enhance solubility in aqueous solutions. "The more hydrogen bonds, the better!"
  • Effect of Chlorine: The presence of chlorine may influence solubility by either increasing hydrophobic interactions in non-polar solvents or providing organophilicity in certain conditions.

Overall, while the exact solubility characteristics can depend on factors such as temperature and pH, one can anticipate an increased likelihood of solubility in polar solvents primarily due to the compound's structure. Conducting solubility tests would be essential in practical applications to ascertain the compound's solubility in specific solvents.

Interesting facts

2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

This compound is a fascinating example of organic chemistry, particularly due to its unique structure that combines both pyrrolo-pyrimidine and tetrahydrofuran frameworks. Here are some interesting facts about this chemical compound:

  • Diverse Functionalities: One of the remarkable aspects of this compound is its ability to engage in various chemical interactions thanks to functional groups such as amino, hydroxymethyl, and diol. This diversity enhances its potential applications in medicinal chemistry.
  • Biological Potential: Compounds containing pyrrolo-pyrimidine substructures have been studied for their roles as kinase inhibitors. Kinases are crucial in cell signaling, making this compound potentially valuable in drug development for cancer and other diseases.
  • Versatile Synthetic Routes: Due to its intricate structure, the synthesis of this compound may involve multiple steps, utilizing various organic reactions. This can provide excellent opportunities for students and chemists to explore synthetic methodologies, including nucleophilic substitutions and condensation reactions.
  • Research Applications: Owing to its complex nature, this compound is of interest for research in both *pharmaceutical* and *material science*. Its properties might be explored in the development of novel therapeutics or advanced polymers.
  • Insight into Structure-Activity Relationships (SAR): Understanding how the structure of this compound relates to its biological activity is crucial. This offers a valuable lesson in pharmacology where modifications to specific parts of the molecule can significantly alter its effectiveness.

In conclusion, 2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol is not only a complex chemical entity but also a potential candidate for further studies in drug design and development. As you explore this compound, think about how its unique features can inspire new innovations in chemical sciences!

Synonyms
7-Deazadenosine
Antibiotic 155B2T
Adenosine, 7-deaza-
2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol
4-Amino-7.beta.-D-ribofuranosyl-7H-pyrrolo(2,3-d)pyrimidine
7.beta.-D-Ribofuranosyl-7H-pyrrolo(2,3-d)pyrimidine-4-amine
NSC56408
NSC 56408
U 10071
B 120121
2-{4-AMINOPYRROLO[2,3-D]PYRIMIDIN-7-YL}-5-(HYDROXYMETHYL)OXOLANE-3,4-DIOL
7-pentofuranosyl-7h-pyrrolo[2,3-d]pyrimidin-4-amine
4-Amino-7-(.beta.-D-ribofuranosyl)-pyrrolo(2,3-d)pyrimidine
7H-Pyrrolo(2,3-d)pyrimidine, 4-amino-7.beta.-D-ribofuranosyl-
SCHEMBL1652797
SCHEMBL20418952
SCHEMBL23982115
DTXSID60861614
DB-102128
NS00078824
7H-Pyrrolo(2, 4-amino-7.beta.-D-ribofuranosyl-
WLN: T56 BN GN INJ FZ I- BT5OTJ CQ DQ E1Q
4-Amino-7-.beta.-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine
7-.beta.-D-ribofuranosyl-7H-pyrrolo-[2,3-d]pyrimidin-4-amine
7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-.beta.-D-ribofuranosyl-
(2R,3R,4S,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol