Amisulpride | Solubility of Things

Identification

Molecular formula

C₁₇H₂₇Cl₂N₃O₄S

CAS number

71675-85-9

IUPAC name

2-(4-aminophenyl)sulfonylguanidine

State

At room temperature, Amisulpride is a solid. It is commonly used in various pharmaceutical formulations, where it must be finely milled into a powder to ensure even distribution within capsules or tablets.

Melting point (Celsius)

126.00

Melting point (Kelvin)

399.15

Boiling point (Celsius)

557.70

Boiling point (Kelvin)

830.85

General information

Molecular weight

314.40g/mol

Molar mass

314.4040g/mol

Density

1.4200g/cm³

Appearence

Amisulpride typically appears as a white to off-white powder. It is a solid at room temperature and is generally found in a crystalline form. The compound is not volatile and has a relatively high melting point, indicative of strong intermolecular forces.

Comment on solubility

Solubility of 2-(4-aminophenyl)sulfonylguanidine

2-(4-aminophenyl)sulfonylguanidine, with the chemical formula C₁₇H₂₇Cl₂N₃O₄S, demonstrates a unique solubility profile that is influenced by its chemical structure. Understanding its solubility is crucial for various applications in pharmaceuticals and chemical formulations.

Key factors affecting the solubility include:

Polarity: The presence of polar functional groups, such as the sulfonyl group, often enhances solubility in polar solvents like water.
Temperature: Solubility typically increases with temperature, allowing for better dissolution of the compound in solution.
pH Level: As a guanidine derivative, the compound may show varying solubility at different pH levels due to protonation or deprotonation of its amino groups.

In practical scenarios, 2-(4-aminophenyl)sulfonylguanidine is expected to be soluble in:

Organic solvents: Such as ethanol and DMSO, where it can effectively interact due to its hydrophobic and hydrophilic portions.
Water: To a lesser extent, depending on the specific conditions, which makes the understanding of various factors critical.

Overall, the solubility of 2-(4-aminophenyl)sulfonylguanidine can be summarized effectively by stating that it is:

Moderately soluble in polar solvents
Less soluble in nonpolar solvents
Highly dependent on environmental conditions

As noted, solubility is a vital aspect affecting the performance and efficacy of this compound in various applications. Its behavior in solution can significantly influence its chemical reactivity, biological availability, and overall utility in the field of chemistry.

Interesting facts

Interesting Facts about 2-(4-Aminophenyl)sulfonylguanidine

2-(4-Aminophenyl)sulfonylguanidine, also known as a key compound in the realm of medicinal chemistry, boasts unique properties and applications that make it a subject of interest for scientists and students alike.

Key Applications

Pharmaceutical Development: This compound is often explored for its potential therapeutic effects, particularly in the treatment of various diseases due to its guanidine structure.
Biological Activity: It is known for its role as a sulfonamide, which can have antibacterial and antidiabetic properties.

Chemical Properties

Aminophenyl Group: This feature facilitates intermolecular interactions, making it valuable in drug modification
Sulfonamide Functionality: The presence of the sulfonyl group enhances solubility and stability, pivotal in drug formulation.

Scientific Significance

Researchers are particularly fascinated by the implications of structural modifications of this compound, which could lead to:

Improved efficacy in targeted therapies
Reduced side effects in clinical applications

In the words of a notable scientist in the field: "Understanding the nuances of sulfonylguanidine derivatives is key to unlocking novel pharmaceuticals." The ongoing research into 2-(4-aminophenyl)sulfonylguanidine serves as a reminder of the vast potential held within the world of chemical compounds, bridging the gap between laboratory exploration and real-world application.

Synonyms

sulfaguanidine

57-67-0

Sulphaguanidine

Sulfaguanidin

Sulfaguine

Sulfanilylguanidine

Sulfanilguanidine

Sulfaguanil

Sulfoguanidine

Sulfoguanil

Sulfoguanyl

Aterian

Guanicil

Sulfentidine

Abiguanil

Guanidan

Ganidan

Guamide

Sulfaguanidina

Sulfaguanidinum

Sulfoquanidine

2-(4-aminophenyl)sulfonylguanidine

Orgaguanidon

Resulfon

Sulfoguenil

Diacta

Ruocid

Suganyl

Sulgin

N1-Amidinosulfanilamide

S-Guanidine

N-Guanylsulfanilamide

1-Sulfanilylguanidine

Shigatox

Benzenesulfonamide, 4-amino-N-(aminoiminomethyl)-

Guanidine, sulfanilyl-

Solfaguanidina

Sulginum

p-Aminobenzenesulfonylguanidine

p-Aminobenzenesulfoguanidide

RP 2275

Sulfaguamidine

Sulfanilamide, n(sup1)-amidino-

Sulfanilamide, N1-amidino-

Sulfaguanidine [INN]

((p-Aminophenyl)sulfonyl)guanidine

4-Amino-N-(aminoiminomethyl)benzenesulfonamide

((4-Aminophenyl)sulfonyl)guanidine

Solfaguanidina [DCIT]

1-((p-Aminophenyl)sulfonyl)guanidine

4-Amino-N-(diaminomethylene)benzenesulfonamide

4-amino-N-carbamimidoylbenzenesulfonamide

Sulfaguanidinum [INN-Latin]

N(sup 1)-Guanylsulfanilamide

N1-Guanylsulfanilamide

Sulfaguanidina [INN-Spanish]

4-Aminobenzenesulfonylguanidine

A-307

N(sup 1)-Amidinosulfanilamide

N-p-Aminobenzenesulphonylguanidine monohydrate

Emerin (pharmaceutical)

Emerin (pharmaceutical) (VAN)

EINECS 200-345-9

NSC 14041

NSC-14041

UNII-15XQ8043FN

2-sulfanilylguanidine

Sulfaguanidine [INN:BAN:NF]

Benzenesulfonamide, 4-amino-N-(diaminomethylene)-

N(sup 1)-(Diaminomethylene)sulfanilamide

61116-95-8

DTXSID1023609

Sulfaguanidine (INN)

AI3-01048

15XQ8043FN

N1-Guanidylsulfanilamide

Sulfanilamide, N(sup 1)-amidino-

1-(4-aminophenyl)sulfonylguanidine

N-1-Amidinosulfanilamide

SULFAGUANIDINE [MI]

4-aminophenylsulfonylguanidine

SULFAGUANIDINE [MART.]

CHEMBL338802

DTXCID103609

SULFAGUANIDINE [WHO-DD]

CHEBI:94621

6190-55-2

N-(4-aminobenzenesulfonyl)guanidine

SULFAGUANIDINE [EP IMPURITY]

SULFAGUANIDINE [EP MONOGRAPH]

Sulfanilamide, N1-(diaminomethylene)-

CAS-57-67-0

NCGC00016252-01

4-Amino-N-carbamimidoylbenzene-1-sulfonamide

4-Amino-N-diaminomethylene-benzenesulfonamide

SULFADIAZINE IMPURITY C [EP IMPURITY]

SULFADIMIDINE IMPURITY C [EP IMPURITY]

4-amino-N-(diaminomethylidene)benzenesulfonamide

Sulfaguanidinum (INN-Latin)

Sulfaguanidina (INN-Spanish)

SULFAGUANIDINE (MART.)

[(p-Aminophenyl)sulfonyl]guanidine

[(4-Aminophenyl)sulfonyl]guanidine

SULFAGUANIDINE (EP IMPURITY)

SULFAGUANIDINE (EP MONOGRAPH)

1-[(p-Aminophenyl)sulfonyl]guanidine

SULFADIAZINE IMPURITY C (EP IMPURITY)

SULFADIMIDINE IMPURITY C (EP IMPURITY)

SR-01000000167

4-amino-N-[amino(imino)methyl]benzenesulfonamide

N(sup1)-Guanylsulfanilamide

ulfaguanidine

Guanimycin

N(sup1)-Amidinosulfanilamide

Veto centre

Veto-centre

Gppe susp fte

4-Amino-N-guanylbenzenesulfonamide

Ulfaguanidine,(S)

Sulfanilyl guanidine

Prestwick_429

MFCD00038136

Spectrum_001412

amino[(4-aminophenyl)sulfonyl]carboxamidine

WLN: ZR DSWMYZUM

Prestwick0_000010

Prestwick1_000010

Prestwick2_000010

Prestwick3_000010

Spectrum2_001420

Spectrum3_001456

Spectrum4_000429

Spectrum5_001197

Sulfaguanidine (Standard)

GastroEntericanis Biocanina

Gastro Entericanis Biocanina

Gastro-Entericanis Biocanina

SCHEMBL93639

SCHEMBL93640

BSPBio_000019

BSPBio_002951

KBioGR_000758

KBioSS_001892

MLS000069712

DivK1c_000633

SPECTRUM1501146

SPBio_001500

SPBio_001940

aniline, 4-guanidinosulphonyl-

BPBio1_000021

GTPL12639

HMS501P15

HY-B1267R

KBio1_000633

KBio2_001892

KBio2_004460

KBio2_007028

KBio3_002451

A07AB03

NINDS_000633

HMS1568A21

HMS1921J19

HMS2092H05

HMS2095A21

HMS3652J05

HMS3712A21

Pharmakon1600-01501146

Sulfanilamide, N1-amidino-(8CI)

4-Amino-N-amidinobenzenesulfonamide

ALBB-035791

HY-B1267

NSC14041

Tox21_110329

BDBM50027795

CCG-38973

NSC757861

s4175

STK031666

STK064640

AKOS000121440

AKOS000319495

N''-(4-aminobenzenesulfonyl)guanidine

Tox21_110329_1

2-[(4-Aminobenzene)sulfonyl]guanidine

CS-4677

DB13726

NSC-757861

IDI1_000633

SMP1_000283

NCGC00018234-01

NCGC00018234-02

NCGC00018234-03

NCGC00018234-04

NCGC00018234-05

NCGC00018234-07

NCGC00024191-03

NCGC00024191-04

AC-10943

DA-58168

SMR000058191

SBI-0051658.P002

SBI-0051658.P003

DB-291822

AB00052220

NS00000003

SW196658-2

EN300-34321

D02437

F85238

Sulfaguanidine 1000 microg/mL in Acetonitrile

AB00052220_15

AB00052220_16

4-amino-N-(amino-imino-methyl)-benzenesulfonamide

8R-0841

Q414886

Sulfaguanidine, VETRANAL(TM), analytical standard

1N-amino(imino)methyl-4-amino-1-benzenesulfonamide

SR-01000000167-2

SR-01000000167-3

SR-01000000167-4

4-amino-N-[(E)-amino(imino)methyl]benzenesulfonamide

4-amino-N-[(Z)-amino(imino)methyl]benzenesulfonamide

BRD-K45086103-001-14-8

BRD-K45086103-001-15-5

BRD-K45086103-001-16-3

Z56758608

1-Amino-4-(([amino(imino)methyl]amino)sulfonyl)benzene #

Sulfaguanidine, European Pharmacopoeia (EP) Reference Standard

{[Amino(imino)methyl]amino}(4-aminophenyl)dioxo-lambda6-sulfane

2-[(dioxidosulfanyl)amino]-1,9-dihydro-6H-purin-6-one[sulfaguanine]

200-345-9

QA9