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Zidovudine

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Identification
Molecular formula
C10H13N5O4
CAS number
30516-87-1
IUPAC name
2-(4-aminoimidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
State
State

Zidovudine is typically found as a solid at room temperature.

Melting point (Celsius)
123.00
Melting point (Kelvin)
396.15
Boiling point (Celsius)
143.00
Boiling point (Kelvin)
416.15
General information
Molecular weight
267.24g/mol
Molar mass
267.2410g/mol
Density
1.3600g/cm3
Appearence

Zidovudine is a white to off-white, odorless, crystalline powder.

Comment on solubility

Solubility of 2-(4-aminoimidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (C10H13N5O4)

The solubility of this complex compound is influenced by several factors, including its molecular structure and functional groups. Understanding its solubility is crucial, especially in applications related to pharmaceuticals and biochemical research. Here are some key points to consider:

  • Polarity: The presence of hydroxymethyl and amino groups suggests that the compound is likely to exhibit some degree of polarity, which can enhance its solubility in polar solvents like water.
  • Hydrogen Bonding: The substitution of hydroxymethyl and amino groups may allow for strong hydrogen bonding interactions with solvent molecules, potentially increasing solubility in aqueous environments.
  • Solvent Compatibility: Due to its complex structure, the compound may also show varied solubility in organic solvents. It could be soluble in alcohols or other polar organic solvents due to the hydrophilic nature of some functional groups.
  • pH Sensitivity: The solubility could change with pH, especially if the amino group can protonate, suggesting that testing across different pH levels would provide a comprehensive view of solubility behavior.

In summary, while the solubility of 2-(4-aminoimidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol is expected to be relatively favorable in polar solvents due to its polar functional groups and capacity for hydrogen bonding, its exact solubility must be empirically determined. This complexity highlights the importance of conducting thorough solubility tests for practical applications.

Interesting facts

Interesting Facts About 2-(4-aminoimidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

This intriguing compound, 2-(4-aminoimidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol, showcases the beauty and complexity of organic chemistry with its diverse functionality. Here are some key highlights:

  • Structure and Composition: The compound contains a fused imidazo-pyridine moiety, which is significant in various biochemical applications. Its unique three-dimensional structure is of interest to chemists studying molecular interactions and properties.
  • Biological Relevance: Compounds such as this often serve as precursors or key intermediates in pharmaceutical development. The presence of amino and hydroxymethyl groups may contribute to biological activity, potentially influencing processes like enzyme inhibition or receptor binding.
  • Research Applications: The compound’s structural characteristics make it a promising candidate for investigations in medicinal chemistry, especially in the context of developing new therapeutic agents targeting specific diseases or conditions.
  • Versatility in Synthesis: The intricate synthesis of this compound paves the way for the exploration of diverse reaction conditions and methodologies. Such pursuits deepen our understanding of organic synthesis and open doors for creating novel derivatives.
  • Potential Environmental Impact: As a product derived from intricate organic reactions, understanding the environmental implications of its synthesis and degradation pathways is crucial. Chemists prioritize sustainability in research to minimize negative ecological effects.

Moreover, it’s fascinating to note that the incorporation of multiple functional groups can lead to enhanced reactivity and cross-reactivity with various biological molecules. The study and application of this compound exemplify the intersection of organic chemistry and biological sciences, an area rich for exploration and discovery. As stated by renowned chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." Indeed, the exploration of compounds like this one contributes significantly to the pool of *ideas* in chemical research.

Synonyms
Adenosine, 3-deaza-
MLS003106659
3dAdo
2-(4-aminoimidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol
DEAE-Cellulose, (approx. 70per cent moisture content)
NSC167897
1-pentofuranosyl-1h-imidazo[4,5-c]pyridin-4-amine
CHEMBL17777
SCHEMBL17780621
SCHEMBL20418948
DTXSID70859986
PD066520
SMR001821551
1H-Imidazo[4, 1-.beta.-D-ribofuranosyl-
DB-122685
Diethylaminoethyl cellulose (DEAE-Cellulose)
1H-Imidazo[4, 4-amino-1-.beta.-D-ribofuranosyl-
1-.beta.-d-Arabinofuranosyl-1H-imidazo[4,5-c]pyridin-4-amine