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Trazodone

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Identification
Molecular formula
C19H22N4O2
CAS number
19794-93-5
IUPAC name
2-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]isoindoline-1,3-dione
State
State

At room temperature, trazodone is in a solid state, typically available in tablet form for pharmaceutical use.

Melting point (Celsius)
139.50
Melting point (Kelvin)
412.70
Boiling point (Celsius)
493.50
Boiling point (Kelvin)
766.70
General information
Molecular weight
371.40g/mol
Molar mass
371.8370g/mol
Density
0.9810g/cm3
Appearence

Trazodone is typically a white to off-white crystalline powder. It is odourless and has a bitter taste.

Comment on solubility

Solubility of 2-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]isoindoline-1,3-dione

The solubility of the compound 2-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]isoindoline-1,3-dione, with the chemical formula C19H22N4O2, is an important characteristic that can dictate its applications as well as its behavior in various environments. Understanding the solubility can provide insights into its potential effectiveness in biological systems and pharmaceuticals. Here are several key points regarding its solubility:

  • General Solubility Characteristics: Given its complex structure, predicting the solubility without empirical data can be challenging. However, the presence of various functional groups can influence its solubility in different solvents.
  • Polar and Nonpolar Solvents: Compounds similar in structure to this one often show enhanced solubility in polar solvents like methanol and ethanol, while exhibiting reduced solubility in nonpolar solvents such as hexane.
  • pH Influence: The solubility may also be affected by pH levels, particularly if the compound can ionize in solution, impacting its interactions with water molecules.
  • Temperature Effects: Typically, an increase in temperature can lead to increased solubility for many organic compounds, although this can vary based on specific interactions within the molecule.

In conclusion, while specific solubility data for this compound may require experimental determination, the structural characteristics suggest its solubility could be influenced significantly by the solvent environment and conditions. Therefore, it is essential to consider these factors when evaluating its practical applications.

Interesting facts

Interesting Facts About 2-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]butyl]isoindoline-1,3-dione

This compound, often referred to in scientific literature as a part of a broader class of pharmaceuticals, showcases several fascinating properties and applications that are notable for chemists and researchers alike.

Pharmacological Relevance

  • Potential Therapeutic Uses: Structures similar to this compound have been investigated for their potential in treating various neurological disorders, including anxiety and depression. The presence of the piperazine moiety may contribute to its pharmacological activity.
  • Mechanism of Action: Compounds with similar frameworks typically act as modulators of neurotransmitter systems, suggesting that they could influence dopamine and serotonin levels in the brain.

Chemical Structure Insights

The unique arrangement of atoms in this molecule contributes to its biological properties. The isoindoline core is particularly interesting:

  • Rigid Structure: The isoindoline ring provides a rigid scaffold that can facilitate specific interactions with biological targets.
  • Substituent Variability: The substituents on the piperazine and methoxy groups can greatly influence the compound's lipophilicity and bioavailability, impacting its overall efficacy.

Synthesis and Applications

Synthesizing such compounds often involves complex organic reactions, making them intriguing to synthetic chemists. Common methods include:

  • Coupling Reactions: Creating the intricate linkages often requires skillful use of coupling agents.
  • Aromatic Substitution: The methoxy group introduces specific electronic properties that can enhance the reactivity at the aromatic site.

As research continues into the structure-activity relationship (SAR) of such compounds, the potential for new drug development is immense. To quote a notable researcher in medicinal chemistry:

“The complexity of small molecules holds the key to unlocking new therapeutic avenues.”

In conclusion, 2-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]isoindoline-1,3-dione is more than just a string of chemical symbols; it represents the intricate dance of chemistry and biology. Its potential roles in medicinal applications can pave the way for innovative treatments in the future.

Synonyms
NAN-190
Nan 190
102392-05-2
NAN190
2-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]isoindole-1,3-dione
LQE19CTV54
1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine
CHEBI:64131
UNII-LQE19CTV54
CHEMBL8618
DTXSID3043813
2-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)isoindoline-1,3-dione
1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]-
2-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-1H-isoindole-1,3(2H)-dione
1-(2-methoxyphenyl)-4-(4-phthalimidobutyl)piperazine
4-(2-Methoxyphenyl)-1-(4-(N-phthalimido)butyl)piperazine
1H-Isoindole-1,3(2H)-dione, 2-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-
2-(4-(4-(2-Methoxyphenyl)-1-piperazinyl)butyl)-1H-isoindole-1,3(2H)-dione
2-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)isoindole-1,3-dione
2-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-isoindole-1,3-dione
1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine
2-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]isoindoline-1,3-dione
2-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-1H-isoindole-1,3(2H)-dione
NCGC00024648-01
Tocris-0553
Lopac-N-3529
Biomol-NT_000099
GTPL73
Lopac0_000876
BPBio1_001363
SCHEMBL2231820
DTXCID1023813
BDBM82517
AKOS002254641
CAS_107966
CCG-204958
NSC_107966
SDCCGSBI-0050851.P002
NCGC00015736-01
NCGC00015736-02
NCGC00015736-03
NCGC00015736-04
NCGC00015736-05
NCGC00015736-08
NCGC00024648-02
NCGC00024648-03
DA-16218
HY-19818
CS-0016844
L000685
Q6952318
BRD-K69195780-001-01-5
BRD-K69195780-004-03-5
BRD-K69195780-004-08-4
N-{4-[4-(2-methyloxyphenyl)piperazinyl]butyl}phthalimide
2-Pyrrol4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butylmorpho-isoindole-1,3-dione