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Trifluoperazine

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Identification
Molecular formula
C21H24F3N3O1S1
CAS number
117-89-5
IUPAC name
2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl heptanoate
State
State

At room temperature, trifluoperazine is in a solid state. It is not volatile and is commonly used in its salt form for pharmaceutical purposes.

Melting point (Celsius)
258.00
Melting point (Kelvin)
531.15
Boiling point (Celsius)
455.50
Boiling point (Kelvin)
728.65
General information
Molecular weight
407.49g/mol
Molar mass
407.4860g/mol
Density
1.3300g/cm3
Appearence

Trifluoperazine is typically found as a white to off-white crystalline powder. It is odorless and has a bitter taste.

Comment on solubility

Solubility Characteristics of 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl heptanoate

The solubility of the compound 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl heptanoate (C21H24F3N3O1S1) can be influenced by various factors, primarily its molecular structure, functional groups, and the surrounding medium.

  • Polarity: Due to the presence of various functional groups such as the trifluoromethyl group, the compound exhibits a unique polarity profile that can enhance its solubility in polar solvents, while potentially decreasing solubility in nonpolar environments.
  • Hydrophobic Interactions: The heptanoate portion contributes to hydrophobic characteristics, which may limit solubility in highly polar solvents or water.
  • Solubility Behavior: Overall, one might expect:
    • Moderate solubility in organic solvents due to hydrophobic regions.
    • Reduced solubility in aqueous solutions primarily due to the bulky phenothiazine moiety.

Understanding the solubility of this compound is essential for assessing its applications in pharmaceuticals or materials science. As with many complex organic molecules, careful consideration of solvent choice can lead to valuable insights into its behavior and reactivity.

Interesting facts

Interesting Facts about 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl heptanoate

This compound, with a complex and multifaceted structure, is part of a class of chemicals that prominently feature in pharmacological research. Known for its potential therapeutic properties, particularly in the field of psychiatry and neurology, it showcases the intricate relationship between chemical structure and biological activity.

Key Highlights:

  • Active Pharmacological Properties: The compound is thought to exhibit interactions with various neurotransmitter systems, which makes it a candidate for further investigations in treating mental health disorders.
  • Unique Structural Features: The inclusion of a trifluoromethyl group significantly enhances its lipophilicity, potentially affecting its distribution and activity within biological systems.
  • Phenothiazine Backbone: This class of compounds has a well-established history in medicine, being foundational in the development of antipsychotic medications, and this derivative continues that tradition with possible improvements in efficacy and side effect profiles.

As scientists explore the mechanisms of action for such compounds, they can highlight interesting interactions at the molecular level. The compound acts by potentially binding to receptors such as dopamine D2 and serotonin 5-HT2, thus modifying neurotransmission in the brain and leading to therapeutic effects.

In conclusion, the exploration of this compound not only exemplifies the importance of chemical modifications in drug design but also represents a significant area of study in molecular pharmacology, offering insights into how nuanced changes in structure can lead to vastly different biological outcomes.

Synonyms
fluphenazine enanthate
2746-81-8
Fluphenazine enantate
Prolixin Enanthate
Eutimox
Moditen enanthate
Moditen-retard
Fluphenazine O-enantate
Flufenan
SQ 16,114
CCRIS 4033
UNII-QSB34YF0W9
EINECS 220-385-0
QSB34YF0W9
4-(3-(2-Trifluoromethyl-10-phenothiazinyl)propyl)-1-piperazineethanol enanthate
BRN 0598595
SQ 16144
2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl heptanoate
CHEBI:5125
Heptanoic acid, 2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperazinyl)ethyl ester
DTXSID6023070
Fluphenazine enanthate [USP:JAN]
2-(4-(3-(2-(Trifluoromethyl)phenothiazin-10-yl)propyl)-1-piperazinyl)ethyl heptanoate
2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethyl heptanoate
2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethyl heptanoate
Heptanoic acid, 2-(4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1-piperazinyl)ethyl ester
Fluphenazine enanthate (USP:JAN)
FLUPHENAZINE ENANTATE (MART.)
FLUPHENAZINE ENANTATE [MART.]
Heptanoic acid, 2-[4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazinyl]ethyl ester
Fluphenazine enanthate [JAN]
FLUPHENAZINE ENANTATE (EP MONOGRAPH)
FLUPHENAZINE ENANTATE [EP MONOGRAPH]
FLUPHENAZINE ENANTHATE (USP MONOGRAPH)
FLUPHENAZINE ENANTHATE [USP MONOGRAPH]
Fluphenazini enantas
Prolixin enanthate (TN)
SCHEMBL120793
DTXCID403070
CHEMBL1200951
FLUPHENAZINE ENANTHATE [MI]
Fluphenazine enanthate (JP17/USP)
MFCD00866641
FLUPHENAZINE ENANTHATE [VANDF]
AKOS003589053
FLUPHENAZINE ENANTATE [WHO-DD]
FLUPHENAZINE ENANTATE [WHO-IP]
Heptanoic acid, 2-(4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)- 1-piperazinyl)ethyl ester
SQ-16144
DB-216891
FLUPHENAZINE ENANTHATE [ORANGE BOOK]
FLUPHENAZINI ENANTAS [WHO-IP LATIN]
HY-107947
CS-0030966
NS00028311
C07955
D00792
FLUPHENAZINE DECANOATE IMPURITY C [EP IMPURITY]
Q27106667
2-(4-(3-(2-(Trifluoromethyl)phenothiazin-10-yl)propyl)-1-piperazinyl))ethyl heptanoate
2-(4-(3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl)-1-piperazinyl)ethyl heptanoate #
220-385-0