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Fluphenazine decanoate

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Identification
Molecular formula
C32H44F3N3O2S
CAS number
553-03-7
IUPAC name
2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl decanoate
State
State

At room temperature, Fluphenazine decanoate is in a liquid state, making it suitable for intramuscular depot injection formulations.

Melting point (Celsius)
5.00
Melting point (Kelvin)
278.15
Boiling point (Celsius)
466.30
Boiling point (Kelvin)
739.45
General information
Molecular weight
579.77g/mol
Molar mass
579.7520g/mol
Density
1.1700g/cm3
Appearence

Fluphenazine decanoate is typically encountered as a clear, colorless or pale yellow viscous liquid. It may appear slightly oily in consistency and has no distinct odor.

Comment on solubility

Solubility of 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl decanoate

The solubility of 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl decanoate (C32H44F3N3O2S) can be quite intriguing due to its complex structure and varying interactions with solvents.

In general, the solubility of organic compounds like this one can be influenced by several factors, including:

  • Polarity: The presence of polar functional groups can enhance solubility in polar solvents, while nonpolar regions will favor solubility in nonpolar solvents.
  • Hydrophobicity: The trifluoromethyl and decanoate moieties may contribute to hydrophobic interactions, affecting overall solubility.
  • Temperature: In many cases, increasing temperature can improve solubility by overcoming intermolecular forces.

As a general observation, compounds with long-chain fatty acid groups, like the decanoate part, tend to have limited solubility in water yet may dissolve well in organic solvents such as dimethyl sulfoxide (DMSO) or ethanol.

It is also important to consider that some **experimental solubility data** may be necessary to fully understand its behavior in various media. As one study notes, "the interaction capacity of the compound with solvents often dictates its operational usability in formulations." This showcases the need for empirical research tailored to the compound's characteristics.

In summary, while the precise solubility of this compound requires further investigation, one can expect that it will display differential solubility across various solvents influenced by its structural attributes.

Interesting facts

Interesting Facts about 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl decanoate

This intriguing compound is a derivative of phenothiazine, a class of chemicals known for their diverse applications in medicinal chemistry. Here are some fascinating insights:

  • Pharmacological Applications: Phenothiazines, including this compound, are primarily known for their use as antipsychotic medications. They can influence dopamine receptors, making them effective in managing psychotic disorders.
  • Fluorine Substitution: The presence of a trifluoromethyl group adds unique properties to the molecule, enhancing its pharmacological activity and potentially affecting lipophilicity, leading to improved bioavailability.
  • Piperazine Linkage: The piperazine moiety is well-recognized in medicinal chemistry for its versatility. It often provides stability and enhances the compound's binding affinity to target receptors.
  • Decanoate Ester Moiety: The ester functional group derived from decanoic acid may influence the compound's release profile in biological systems, suggesting potential for extended-release formulations.
  • Physical-chemical Properties: The complex structure of this compound likely results in unique solubility and stability profiles, which can be critical for its efficacy in therapeutic applications.

This compound is not only a representative of advanced molecular design in pharmaceuticals but also showcases the intricate balance between structure and function that defines modern medicinal chemistry. As a future scientist or chemist, understanding such compounds can pave the way for innovative treatments that could revolutionize patient care.

In the words of a renowned chemist, “The best way to predict the future is to invent it.” This compound, with its sophisticated design and multifaceted properties, exemplifies the exciting possibilities that lie ahead in chemical research.

Synonyms
Fluphenazine decanoate
5002-47-1
Modecate
Fluphenazine depot
Moditen depot
Dapotum D
Prolixin decanoate
Lyogen
Flufenazine decanoate
Fluorophenazine decanoate
Fluphenazine O-decanoate
Fluphenaline decanoate
SQ 10,733
CCRIS 3954
Dapotum depot
UNII-FMU62K1L3C
Anatensol decanoate
EINECS 225-672-4
FMU62K1L3C
NSC 169510
NSC-169510
2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl decanoate
BRN 0599852
DEPOT
2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethyl decanoate
QD-10733
SQ-10733
2-(4-(3-(2-(Trifluoromethyl)phenothiazin-10-yl)propyl)-1-piperazinyl)ethyl decanoate
CHEBI:5124
Decanoic acid, 2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperazinyl)ethyl ester
DTXSID7023069
NSC169510
Decanoic acid, 2-(4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1-piperazinyl)ethyl ester
Fluphenazine decanoate [USP:BAN:JAN]
N-Fmoc-L-alanine-d4
2-(4-(3-(2-(Trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethyl decanoate
Decanoic acid, 2-[4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazinyl]ethyl ester
Decanoic acid, 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]-1-piperazinyl]ethyl ester
Fluphenazine Decanoate (~90%)
Moditen-depo
FLUPHENAZINE DECANOATE (MART.)
FLUPHENAZINE DECANOATE [MART.]
L-Alanine-2,3,3,3-d4-N-FMOC
Fluphenazine decanoate (USP:BAN:JAN)
DECANOIC ACID, 2-(4-(3-(2-(TRIFLUOROMETHYL)-10H-DECANOATE PHENOTHIAZIN-10-YL)PROPYL)-1-PIPERAZINYL)ETHYL ESTER
FLUPHENAZINE DECANOATE (EP MONOGRAPH)
FLUPHENAZINE DECANOATE (USP IMPURITY)
FLUPHENAZINE DECANOATE [EP MONOGRAPH]
FLUPHENAZINE DECANOATE [USP IMPURITY]
ftorphenazine decanoate
FLUPHENAZINE DECANOATE (USP MONOGRAPH)
FLUPHENAZINE DECANOATE [USP MONOGRAPH]
Prolixin decanoate (TN)
2-[4-[3-[2-(Trifluoromethyl)phenothiazin-10-yl]propyl]-1-piperazinyl]ethyl decanoate
Fluphenazine decanoate (JAN/USP)
Fluphenazine decanoate; 2-[4-[3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl decanoate
Fluphenazini decanoas
MFCD00798504
fluphenazine-decanoate
SCHEMBL41288
MLS006010097
DTXCID703069
CHEMBL1200854
HY-B1904R
Fluphenazine decanoate (Standard)
FLUPHENAZINE DECANOATE [MI]
BCP18078
HY-B1904
FLUPHENAZINE DECANOATE [JAN]
FLUPHENAZINE DECANOATE [VANDF]
AKOS003589045
FLUPHENAZINE DECANOATE [WHO-DD]
FLUPHENAZINE DECANOATE [WHO-IP]
NCGC00386699-01
AS-11646
DA-53260
SMR004701239
FLUPHENAZINE DECANOATE [ORANGE BOOK]
CS-0013962
FLUPHENAZINI DECANOAS [WHO-IP LATIN]
NS00020519
C07956
D00793
G12652
SBI-0654177.0001
BRD-K27898013-001-01-4
FLUPHENAZINE ENANTHATE IMPURITY C [EP IMPURITY]
Q27278080
WLN: T C666 BN ISJ EXFFF B3- AT6N DNTJ D2OV9
225-672-4