Interesting facts
Interesting Facts about 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol
This compound is a remarkable example of a synthetic organic molecule with potential therapeutic applications. Here are some intriguing aspects to consider:
- Pharmaceutical Relevance: The compound is closely related to phenothiazine derivatives, which are well-known for their use in antipsychotic medications. These compounds have been instrumental in the treatment of various mental health disorders.
- Structure Complexity: The structure contains a trifluoromethyl group, which can enhance the lipophilicity of the molecule, potentially leading to improved bioavailability and target affinity in biological systems.
- Piperazine Incorporation: The presence of a piperazine ring is notable as piperazine-containing compounds are commonly integrated into drugs for their ability to modulate neurotransmitter systems effectively.
- Scientific Innovation: The combination of a phenothiazine core with a piperazine moiety and an alcohol functional group illustrates the creativity and complexity in drug design aimed at achieving specific therapeutic effects with minimal side effects.
- Fluorinated Compounds: The trifluoromethyl component not only boosts the compound's pharmacological properties but also presents interesting challenges in synthesis and medicinal chemistry, as fluorine introduces specific reactivity and affinity characteristics.
In the words of chemist Linus Pauling, “The best way to have a good idea is to have lots of ideas.” This compound encapsulates the essence of medicinal chemistry, where diverse structural modifications can lead to innovative solutions in health care. The ongoing exploration of such molecules can potentially revolutionize treatments and improve outcomes in various diseases.
Synonyms
FLUPHENAZINE
69-23-8
Triflumethazine
Fluorfenazine
Fluorophenazine
Fluorphenazine
Siqualon
Elinol
Ftorphenazine
Phthorphenazine
Siqualine
Vespazine
Pacinol
Sevinol
Prolixin
Flufenazina
Fluphenazinum
Flufenazin
Flufenazina [DCIT]
SQ 4918
Fluphenazine [INN:BAN]
Moditen (Tabl or elixir)
Fluphenazinum [INN-Latin]
Fluphenazine free base
2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol
Moditen
Moditen (TN)
2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethanol
Fluphenazine (INN)
10-(3-(2-Hydroxyethyl)piperazinopropyl)-2-(trifluoromethyl)phenothiazine
4-(3-(2-Trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol
HSDB 3334
EINECS 200-702-9
4-(3-(-Trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol
NSC 62323
1-(2-Hydroxyethyl)-4-(3-(trifluoromethyl-10-phenothiazinyl)propyl)-piperazine
4-(3-(2-(Trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperazineethanol
1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-
CHEBI:5123
DTXSID2023068
Prolixin (TN)
10-(3'-(4''-(beta-Hydroxyethyl)-1''-piperazinyl)-propyl)-3-trifluoromethylphenothiazine
FLUPHENAZINE [MI]
NSC-62323
FLUPHENAZINE [INN]
S94
FLUPHENAZINE [HSDB]
S79426A41Z
FLUPHENAZINE [VANDF]
FLUPHENAZINE [MART.]
FLUPHENAZINE [WHO-DD]
10-(3'-(4"-(beta-Hydroxyethyl)-1"-piperazinyl)-propyl)-3-trifluoromethylphenothiazine
2-(Trifluoromethyl)-10-(3-(1-(beta-hydroxyethyl)-4-pipe razinyl)propyl)phenothiazine
Phenothiazine, 10-(3-(4-(2-hydroxyethyl)-1-piperazinyl)propyl)-2-(trifluoromethyl)-
DTXCID303068
4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1-Piperazineethanol
NSC62323
Calmansial
1-(2-Hydroxyethyl)-4-[3-(trifluoromethyl-10-phenothiazinyl)propyl]piperazine
1-Piperazineethanol, 4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-
69-23-8 (free base)
2-(4-(3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl)-1-piperazinyl)ethanol
2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethan-1-ol
2-(Trifluoromethyl)-10-(3-(1-(beta-hydroxyethyl)-4-piperazinyl)propyl)phenothiazine
NCGC00015436-07
Yespazine
1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-
4-[3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazineethanol
Fluphenazinum (INN-Latin)
2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethanol
FLUPHENAZINE (MART.)
FLUPHENAZINE DECANOATE IMPURITY B [EP IMPURITY]
FLUPHENAZINE ENANTATE IMPURITY B [EP IMPURITY]
FLUPHENAZINE ENANTHATE IMPURITY B [EP IMPURITY]
MLS001076508
4-[3-(2-Trifluoromethyl-10-phenothiazyl)-propyl]-1-piperazineethanol
CAS-69-23-8
FLUPHENAZINE DECANOATE IMPURITY B (EP IMPURITY)
FLUPHENAZINE ENANTATE IMPURITY B (EP IMPURITY)
FLUPHENAZINE ENANTHATE IMPURITY B (EP IMPURITY)
flufenazine
Fludecasin
Fluphenazin
A 4077
Fludecate
Funazine
Metoten
Lyogen Depot
Lyogen Retard
Moditen Depo
1-Piperazineethanol, 4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]-
UNII-S79426A41Z
2-(4-(3-(2-(Trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperazinyl)ethanol
2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethan-1-ol
2-(4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)piperazin-1-yl)ethanol
Permitil (Salt/Mix)
Prolixin (Salt/Mix)
Tensofin (Salt/Mix)
Anatensol (Salt/Mix)
Prolixine (Salt/Mix)
Spectrum_000289
Prestwick0_000320
Prestwick1_000320
Prestwick2_000320
Prestwick3_000320
Spectrum2_001199
Spectrum3_001420
Spectrum4_000828
Spectrum5_001536
Lopac-F-4765
ChemDiv1_024180
Biomol-NT_000023
CHEMBL726
Probes1_000254
Probes2_000295
cid_3372
BIDD:PXR0184
Lopac0_000555
SCHEMBL19221
BSPBio_000320
BSPBio_003100
GTPL204
KBioGR_001375
KBioGR_002386
KBioSS_000769
KBioSS_002391
DivK1c_000511
SPBio_001277
SPBio_002539
BPBio1_000352
BPBio1_001187
BDBM78433
cid_6602611
HMS655L02
KBio1_000511
KBio2_000769
KBio2_002386
KBio2_003337
KBio2_004954
KBio2_005905
KBio2_007522
KBio3_002320
KBio3_002865
N05AB02
cMAP_000035
NINDS_000511
HMS2089C16
BCP21399
Tox21_110146
NSC755764
NSC755768
STK050763
AKOS001659031
Tox21_110146_1
CCG-204645
DB00623
NSC-755764
NSC-755768
SDCCGSBI-0050538.P004
1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-(9CI)
2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol dihydrochloride
IDI1_000511
MRF-0000359
NCGC00015436-01
NCGC00015436-02
NCGC00015436-03
NCGC00015436-04
NCGC00015436-05
NCGC00015436-06
NCGC00015436-08
NCGC00015436-09
NCGC00015436-11
NCGC00015436-16
NCGC00024429-03
NCGC00024429-04
AS-76175
CAS-146-56-5
FF102008
S 94
SQ 4,918
SBI-0050538.P003
Fluorfenazine pound (3/4)<<EnAa pound(c)
HY-119980
AB00053587
CS-0078861
NS00005055
C07010
D07977
EN300-708785
G78133
Q58376
AB00053587-18
AB00053587_19
A836405
L000257
SR-01000003048-5
BRD-K55127134-001-01-7
BRD-K55127134-300-05-4
BRD-K55127134-300-07-0
BRD-K55127134-300-11-2
2-(4-(3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl)-1-piperazinyl)ethanol #
2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]propyl]-1-piperazinyl]ethanol
2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]propyl]-1-piperazinyl]ethanol;hydrochloride
2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazino]ethanol;hydrochloride
Phenothiazine, 10-(3-(4-(2-hydroxyethyl)-1-piperazinyl)propyl-2-(trifluoromethyl)
200-702-9
Solubility of 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol (C21H24F3N3OS)
The solubility of the compound 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol can be complex due to its structural intricacies. Here are some important aspects to consider:
In summary, the solubility of 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol is dictated by various factors including solvent type, temperature, pH, and the balance of its chemical moieties. Further experimental analysis would be necessary to determine specific solubility limits and behavior in practical applications.