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Flufenamic acid

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Identification
Molecular formula
C21H16Cl3FNO3
CAS number
530-78-9
IUPAC name
2-[4-[3-[2-(2-chloro-6-fluoro-phenyl)ethyl-[(2,3-dichlorophenyl)carbamoyl]amino]propyl]phenoxy]-2-methyl-propanoic acid
State
State

At room temperature, Flufenamic acid is in a solid state. It is typically found as a crystalline powder and can be somewhat hygroscopic.

Melting point (Celsius)
167.00
Melting point (Kelvin)
440.15
Boiling point (Celsius)
628.20
Boiling point (Kelvin)
901.35
General information
Molecular weight
457.79g/mol
Molar mass
457.7920g/mol
Density
0.0013g/cm3
Appearence

Flufenamic acid appears as a white to off-white crystalline powder. It may not have a distinct odor and is commonly found in solid form, typically as a powder which might clump upon exposure to moisture due to its hygroscopic nature.

Comment on solubility

Solubility of 2-[4-[3-[2-(2-chloro-6-fluoro-phenyl)ethyl-[(2,3-dichlorophenyl)carbamoyl]amino]propyl]phenoxy]-2-methyl-propanoic acid (C21H16Cl3FNO3)

The solubility of this compound is influenced by a variety of structural features and substituents present in its formula. Generally, the solubility characteristics can be summarized as follows:

  • Polarity: The presence of polar groups such as the carboxylic acid (from the propanoic acid part) can enhance solubility in polar solvents like water.
  • Hydrophobicity: Conversely, the chlorinated phenyl units add hydrophobic characteristics, which can lead to decreased solubility in polar solvents.
  • Solvent Choice: This compound may exhibit decent solubility in organic solvents such as dimethyl sulfoxide (DMSO) or methanol, whereas it might struggle to dissolve in aqueous solutions.

In general, the solubility of complex organic molecules like this one often requires careful consideration of the effects of temperature, pH, and the presence of other solutes.

Quotes from various studies indicate that the balance between hydrophilic and hydrophobic properties plays a critical role in understanding solubility:

  • "Understanding the interplay of functional groups is essential for predicting solubility behaviors."
  • "The presence of bulky substituents often challenges solubility in water but may improve it in nonpolar solvents."

In conclusion, while predicting the precise solubility parameters for C21H16Cl3FNO3 necessitates empirical testing, one can cautiously assess its solubility potential based on its structural characteristics.

Interesting facts

Interesting Facts about 2-[4-[3-[2-(2-chloro-6-fluoro-phenyl)ethyl-[(2,3-dichlorophenyl)carbamoyl]amino]propyl]phenoxy]-2-methyl-propanoic acid

This compound, known for its intricate structure and multifaceted properties, belongs to the category of pharmaceuticals often studied for their therapeutic potential. Here are some intriguing insights:

  • Therapeutic Applications: Compounds with similar structures have been explored for their roles in treating various conditions, including inflammation and cancer. The presence of multiple halogens may enhance biological activity.
  • Complex Structure: The compound features a fascinating arrangement of functional groups, including a carbamoyl group and a phenoxy moiety, contributing to its reactivity and interaction with biological targets.
  • Research Interest: Scientists are particularly interested in the properties endowed by halogen substitutions, like chlorine and fluorine, which can significantly affect the pharmacodynamics and pharmacokinetics of the compound.
  • Analogous Compounds: Researchers often compare this compound with other derivatives to assess variations in activity, safety profiles, and mechanisms of action.
  • Environmental Considerations: The presence of multiple chlorine atoms raises questions about environmental stability and bioaccumulation, making this compound a point of interest in green chemistry discussions.

In summary, the 2-[4-[3-[2-(2-chloro-6-fluoro-phenyl)ethyl-[(2,3-dichlorophenyl)carbamoyl]amino]propyl]phenoxy]-2-methyl-propanoic acid compound stands out due to its complexity and potential impacts on both health and the environment. Understanding such compounds is vital for the advancement of medicinal chemistry and therapeutic design.

Synonyms
GW2433
GW 2433
227941-61-9
GW-2433
2-[4-[3-[2-(2-chloro-6-fluorophenyl)ethyl-[(2,3-dichlorophenyl)carbamoyl]amino]propyl]phenoxy]-2-methylpropanoic acid
CHEMBL435278
2-[4-(3-{[2-(2-chloro-6-fluorophenyl)ethyl][(2,3-dichlorophenyl)carbamoyl]amino}propyl)phenoxy]-2-methylpropanoic acid
YMWJDWJXIXITMD-UHFFFAOYSA-N
GTPL2716
SCHEMBL2028308
BDBM28662
AKOS040748501
[3H]GW 2433
2-(4-{3-[1-[2-(2-chloro-6-fluoro-phenyl)-ethyl]-3-(2,3-dichloro-phenyl)-ureido]-propyl}-phenoxy)-2-methyl-propionic acid
HY-120886
Q27077939
2-(4-{3-[1-[2-(2-CHLORO-6-FLUORO-PHENYL)-ETHYL]-3-(2,3-DICHLORO-PHENYL)-UREIDO]-PROPYL}-PHENOXY)-2-METHYL-PROPIONIC