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Folic Acid

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Identification
Molecular formula
C19H19N7O6
CAS number
59-30-3
IUPAC name
2-[[4-[(2,4-diaminopteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
State
State
Folic acid is a solid at room temperature, commonly in the form of a crystalline powder.
Melting point (Celsius)
250.00
Melting point (Kelvin)
523.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
441.40g/mol
Molar mass
441.4000g/mol
Density
1.6000g/cm3
Appearence
Folic acid appears as a bright yellow to orange-yellow crystalline powder.
Comment on solubility

Solubility of 2-[[4-[(2,4-diaminopteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid

The solubility of 2-[[4-[(2,4-diaminopteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid (C19H19N7O6), often influenced by its complex molecular structure, presents a unique case study in the realm of organic compounds.

Factors Affecting Solubility

This compound's solubility can be primarily attributed to a variety of factors, including:

  • Hydrophobic and Hydrophilic Regions: The presence of both hydrophobic groups, which tend to be insoluble in water, and hydrophilic functional groups that promote solubility.
  • Hydrogen Bonding: Capable of forming hydrogen bonds may significantly enhance solubility in polar solvents like water.
  • pH Sensitivity: The ionization of certain functional groups can vary with pH, affecting the solubility in aqueous solutions.

General Observations

In general terms, compounds incorporating multiple amine and carboxylic acid groups tend to have:

  • Increased Solubility: Especially in polar solvents due to potential ionization.
  • Variable Solubility: Depending on temperature and the presence of other ionic species in solution.

While solubility data specifically for this compound may vary, it is likely that the complex nature and presence of multifunctional groups will result in appreciable solubility in aqueous media under certain conditions. Therefore, the assessment of solubility remains crucial for understanding its chemical behaviors, applications, and interactions in different environments.

Interesting facts

Interesting Facts about 2-[[4-[(2,4-diaminopteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid

This compound is a fascinating example of a complex organic molecule that plays a significant role in medicinal chemistry. Specifically, it serves as a potent antitumor agent, making it a target of study in cancer research. Here are some key points to consider:

  • Mechanism of Action: Its structure enables it to inhibit specific enzymes essential for DNA synthesis, disrupting the proliferation of cancer cells.
  • Structure-Activity Relationship: The intricate arrangement of functional groups in this compound is crucial for its biological activity, which underscores the importance of molecular design in drug development.
  • Pteridine Moiety: The inclusion of a pteridine ring system is noteworthy as it is commonly found in several biological systems, notably in folate metabolism.
  • Research Potential: Ongoing studies are investigating modifications to enhance efficacy or reduce side effects, emphasizing the dynamic nature of pharmaceutical research.
  • Combating Resistance: Understanding how this compound interacts at a molecular level can help in overcoming drug resistance that often limits the effectiveness of traditional cancer therapies.

As scientists dive deeper into the properties and applications of compounds like this one, we appreciate the importance of interdisciplinary approaches in tackling complex diseases.

Synonyms
Pteramina
4-Aminopteroylglutamic acid
1236566-87-2
4-Aminofolic acid; APGA
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]glutamic acid
2-(4-(((2,4-Diaminopteridin-6-yl)methyl)amino)benzamido)pentanedioic acid
N-[(4-{[(2,4-diaminopteridin-6-yl)methyl]amino}phenyl)carbonyl]glutamic acid
L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-
4-Aminofolate
4-Aminopteroylglutamate
4-Aminopteroyl-glutamic acid
Aminofolic acid, 4-
SR-01000075636
2-(4-((2,4-DIAMINOPTERIDIN-6-YL)METHYLAMINO)-BENZAMIDO)PENTANEDIOIC ACID
NCGC00015038-03
Spectrum_001874
SpecPlus_000899
Spectrum2_000893
Spectrum3_001386
Spectrum4_000917
Spectrum5_000931
A 1784
SCHEMBL8887
Lopac0_000034
BSPBio_002972
KBioGR_001414
KBioSS_002396
MLS002153337
DivK1c_006995
SPECTRUM1500679
SPBio_000706
SCHEMBL8161477
L-N-[p-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-Glutamic acid
KBio1_001939
KBio2_002391
KBio2_004959
KBio2_007527
KBio3_002192
DTXSID10858993
HMS1921C08
HMS3260G09
Pharmakon1600-01500679
Tox21_500034
CCG-39745
NSC757427
STL477234
AKOS015854984
LP00034
NSC-757427
SB17355
SDCCGSBI-0050023.P004
NCGC00015038-02
NCGC00015038-04
NCGC00015038-05
NCGC00015038-06
NCGC00015038-07
NCGC00015038-08
NCGC00015038-09
NCGC00015038-10
NCGC00015038-12
NCGC00093553-01
NCGC00093553-02
NCGC00093553-03
NCGC00093553-04
NCGC00093553-05
NCGC00093553-06
NCGC00260719-01
AS-75721
SMR001230749
SBI-0050023.P003
DB-052619
EU-0100034
NS00015627
AB00053283_04
SR-01000075636-1
SR-01000075636-5
BRD-A86736466-001-05-9
WLN: T66 BN DN GN JNJ CZ EZ H1MR DVMYVQ2VQ
L-Glutamic acid,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-,
Glutamic acid,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-, L-
2-(4-(((2,4-Diaminopteridin-6-yl)methyl)amino)benzamido)pentanedioicacid