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Pemetrexed

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Identification
Molecular formula
C20H21N5O6
CAS number
137281-23-3
IUPAC name
2-[[4-[2-(2-amino-4-methyl-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid
State
State
Pemetrexed is primarily a solid at room temperature. It is typically found and handled as a dry powder for formulation and administration in pharmaceutical settings.
Melting point (Celsius)
220.50
Melting point (Kelvin)
493.60
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
427.43g/mol
Molar mass
427.4250g/mol
Density
1.7500g/cm3
Appearence

Pemetrexed is a white to almost white, crystalline powder.

Comment on solubility

Solubility of 2-[[4-[2-(2-amino-4-methyl-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid

The compound 2-[[4-[2-(2-amino-4-methyl-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid, represented by the formula C20H21N5O6, exhibits unique solubility characteristics that can be influenced by various factors. Here are some key points regarding its solubility:

  • Water Solubility: This compound may show limited solubility in water due to its complex molecular structure and hydrophobic regions, which tend to repel water molecules.
  • Organic Solvents: It is likely to be more soluble in organic solvents such as dimethyl sulfoxide (DMSO) or methanol, which can stabilize certain functional groups present in the molecule.
  • pH Influence: The solubility might be pH-dependent. In basic conditions, the carboxylic acid groups can ionize, potentially enhancing solubility in aqueous media.
  • Temperature Effects: Increased temperature generally promotes solubility, making it more feasible to dissolve the compound at elevated temperatures.

As with many organic compounds, understanding the solubility of 2-[[4-[2-(2-amino-4-methyl-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid can guide formulation processes in both laboratory and industrial settings. It is essential to consider the environmental conditions when determining the optimal solubility profile for practical applications.

Interesting facts

Discovering 2-[[4-[2-(2-amino-4-methyl-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid

This intriguing compound, often referred to by its abbreviated name, showcases significant potential in medicinal chemistry. Here are some fascinating aspects of this compound:

  • Biological Significance: Compounds like this often possess bioactive properties that can be leveraged in the development of new pharmaceuticals, especially in targeting specific pathways in cancer treatment.
  • Complex Structure: The presence of a pyrrolo[2,3-d]pyrimidine moiety adds complexity and might enhance its ability to interact with molecular targets.
  • Amino Group Functionality: The amino group within the structure can participate in various chemical interactions, potentially leading to increased efficacy in biological applications.
  • Drug Design: This compound exemplifies the principles of drug design, where modifications are made to existing chemical structures to enhance therapeutic effects or reduce side effects.

The intricate design of this compound makes it an exciting candidate for further research. As scientists continue to explore various derivatives and analogs, one can only anticipate the breakthroughs that might emerge from studying such compounds.

In the words of a famous chemist, "Chemistry is the essence of life; understanding it opens the door to innovate and heal." This compound certainly embodies that spirit, reflecting the vast potential of chemistry in improving human health.