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2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine

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Identification
Molecular formula
C15H18N4O2
CAS number
154985-53-4
IUPAC name
2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
State
State

At room temperature, 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine is a solid. Its crystalline structure contributes to its distinctive appearance and stable state under typical ambient conditions.

Melting point (Celsius)
110.00
Melting point (Kelvin)
383.15
Boiling point (Celsius)
470.00
Boiling point (Kelvin)
743.15
General information
Molecular weight
282.33g/mol
Molar mass
282.3300g/mol
Density
1.2435g/cm3
Appearence

The compound is typically in crystalline solid form. The crystals can vary in color from white to a slightly off-white hue. Due to its complex aromatic structure, it may exhibit a slight sheen or gloss under direct light. It is generally odorless unless otherwise specified by impurities or other chemical factors.

Comment on solubility

Solubility of 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine (C15H18N4O2)

The solubility of 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine can be influenced by various factors, including its molecular structure and the presence of functional groups. Here are some key points regarding its solubility:

  • Polarity: The presence of polar functional groups such as amino and carbonyl can contribute to increased solubility in polar solvents.
  • Solvent Effects: Solubility may vary significantly in different solvents. For instance, this compound is likely to be more soluble in water due to its hydrogen-bonding capabilities.
  • Temperature: Generally, increased temperature can enhance solubility, allowing for greater dissolution of solid compounds in solvents.
  • pH Dependence: The solubility of this compound may also be affected by the pH of the solution, particularly if it ionizes in acidic or basic conditions.
  • Structural Considerations: The bulky benzodioxole group could impact overall solubility, making it potentially less soluble in highly nonpolar solvents.

Understanding the solubility of this compound is essential for its applications in different chemical environments. As the saying goes, "Like dissolves like," meaning that the solubility is a crucial factor when considering solvent choices in chemical reactions and formulations.

Interesting facts

Interesting Facts about 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine

This intriguing compound combines structural elements from both pyrimidines and piperazines, leading to a unique molecular assembly that has caught the attention of researchers in various fields. Here are some notable points about this compound:

  • Pharmacological Potential: The piperazine moiety is known for its presence in several pharmacologically active compounds, making this molecule a point of interest for drug discovery.
  • Structural Diversity: The incorporation of a benzodioxole group enhances the structural diversity and potentially increases its bioactivity, showcasing how molecular modifications can lead to new functionalities.
  • Applications: Compounds with similar structures have been explored in the realm of therapeutics, including but not limited to antipsychotic, antidepressant, and anti-inflammatory agents.
  • Mechanistic Insights: Understanding the interaction of this compound with various biological targets could provide insights into molecular mechanisms underlying certain diseases.

As scientists continue to investigate its properties, this compound stands as a testament to the complexity and beauty of chemical synthesis in the development of novel pharmaceuticals. In the words of a famous chemist, "The greatest discoveries are made when we dare to experiment and combine the known with the unknown."

Overall, 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine is not just a chemical entity, but a gateway to new scientific exploration and understanding!

Synonyms
piribedil
3605-01-4
Trivastal
Trivastan
2-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)pyrimidine
ET-495
EU-4200
2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
2-(4-Piperonyl-1-piperazinyl)pyrimidine
Piribedile [DCIT]
ET 495
Piribedile
Piribedilum
Piribedil [INN:DCF]
EU 4200
Piribedilum [INN-Latin]
DO22K1PRDJ
Trivastal (TN)
Piribedil (INN)
1-(2-Pyrimidyl)-4-piperonylpiperazine
DTXSID9045188
PIRIBEDIL [INN]
Pyrimidine, 2-(4-piperonyl-1-piperazinyl)-
PIRIBEDIL [MI]
EINECS 222-764-6
UNII-DO22K1PRDJ
PIRIBEDIL [MART.]
PIRIBEDIL [WHO-DD]
Pyrimidine, 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-
BRN 0963637
2-(4-(3,4-Methylenedioxybenzyl)piperazino)pyrimidine
1-(3,4-Methylenedioxybenzyl)-4-(2-pyrimidyl)piperazine
Piribendyl
DTXCID7025188
2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine
Pyrimidine, 2-(4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)-
NCGC00015857-05
2-(4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl)pyrimidine
2-[4-(2H-1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
Piribedilum (INN-Latin)
PIRIBEDIL (MART.)
1-(2-Pyrimidyl)-4-(3,4-methylenedioxybenzyl)piperazine
2-{4-[(1,3-Benzodioxol-5-yl)methyl]piperazin-1-yl}pyrimidine
CAS-3605-01-4
2-(4-((1,3-Benzodioxol-5-yl)methyl)piperazin-1-yl)pyrimidine
2-(4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl)pyrimidine
Trivastal lp
2-(4-((2H-1,3-benzodioxol-5-yl)methyl)piperazin-1-yl)pyrimidine
2-{4-[(2H-1,3-benzodioxol-5-yl)methyl]piperazin-1-yl}pyrimidine
SR-01000076091
MFCD00868264
Piribedil (Standard)
Tocris-1031
Prestwick0_000980
Prestwick1_000980
Prestwick2_000980
Prestwick3_000980
Lopac-P-9233
Biomol-NT_000044
GTPL49
Cambridge id 5268291
Lopac0_000965
Oprea1_061309
Oprea1_215383
BSPBio_001019
SCHEMBL150101
SPBio_002930
BPBio1_001121
BPBio1_001269
CHEMBL1371770
BDBM85092
CHEBI:92833
N04BC08
2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-pyrimidine
HMS2089M17
HMS3885E19
BCP10553
NSC_4850
Tox21_110245
HY-12707R
s3656
STL497889
AKOS001309525
Tox21_110245_1
AC-1051
CCG-205045
CS-8014
DB12478
ES-0016
FP65134
SDCCGSBI-0050938.P003
NCGC00015857-01
NCGC00015857-02
NCGC00015857-03
NCGC00015857-04
NCGC00015857-06
NCGC00015857-07
NCGC00015857-09
NCGC00015857-16
NCGC00024951-01
NCGC00024951-02
NCGC00024951-03
DA-66746
HY-12707
CAS_3605-01-4
SBI-0050938.P002
CAS-78213-63-5
AB00514645
NS00008358
P2054
D07305
T72361
AB00514645-19
EN300-6492984
AG-690/37046188
L000476
Q413976
BRD-K47936004-001-01-9
BRD-K47936004-003-03-1
BRD-K47936004-003-11-4
SR-01000076091-11
Z31240640
2-{4-[(1,3-dioxaindan-5-yl)methyl]piperazin-1-yl}pyrimidine
2-(4-(Benzo[d][1 pound not3]dioxol-5-ylmethyl)piperazin-1-yl)pyrimidine
222-764-6