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Ezetimibe

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Identification
Molecular formula
C24H21F2NO3
CAS number
163222-33-1
IUPAC name
2-[4-[1-[4-(1-carboxy-1-methyl-propoxy)phenyl]cyclohexyl]phenoxy]-2-methyl-butanoic acid
State
State

This compound is typically a solid at room temperature, appearing as a crystalline powder.

Melting point (Celsius)
163.00
Melting point (Kelvin)
436.00
Boiling point (Celsius)
678.10
Boiling point (Kelvin)
951.30
General information
Molecular weight
409.45g/mol
Molar mass
409.4450g/mol
Density
1.1960g/cm3
Appearence

The compound typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 2-[4-[1-[4-(1-carboxy-1-methyl-propoxy)phenyl]cyclohexyl]phenoxy]-2-methyl-butanoic acid

When exploring the solubility of the compound 2-[4-[1-[4-(1-carboxy-1-methyl-propoxy)phenyl]cyclohexyl]phenoxy]-2-methyl-butanoic acid (C24H21F2NO3), several key factors come into play:

  • Polarity: The presence of the carboxylic acid group suggests that this compound may exhibit some degree of polarity, which typically enhances solubility in polar solvents like water.
  • Hydrophobic Regions: However, the large hydrophobic portions of the molecule, particularly the cyclohexyl and phenoxy groups, can impede solubility in polar media.
  • Solvent Interaction: The solubility can also vary significantly depending on the solvent used. For example, the compound may be more soluble in organic solvents such as ethanol or dimethyl sulfoxide (DMSO) compared to water.
  • Temperature Relevance: As with many organic compounds, increasing the temperature could lead to enhanced solubility.

In summary, predicting the solubility of this compound involves a delicate balance of its polar and non-polar characteristics. It can be said that:

“The solubility of organic compounds is not just dictated by structure, but also by the intermolecular interactions with the solvent.”

Understanding these principles is essential for harnessing the full potential of such complex chemical compounds.

Interesting facts

Interesting Facts about 2-[4-[1-[4-(1-carboxy-1-methyl-propoxy)phenyl]cyclohexyl]phenoxy]-2-methyl-butanoic acid

This compound, often referred to in pharmacological contexts, possesses unique structural features that contribute to its potential biological activity. Here are some engaging insights:

  • Complex Structure: The intricate design of the molecule includes a dual aromatic system linked to a cyclohexyl group, which can enhance its interactions with biological targets.
  • Biological Relevance: Compounds similar to this one are often explored for their therapeutic potential, particularly in the realms of pain management and inflammation moderation.
  • Functional Groups: The presence of a carboxylic acid group not only contributes to its acid-base properties but also plays a critical role in the solubility and receptor binding characteristics of the compound.
  • Research Interest: Ongoing studies may focus on the compound's affinity to certain receptors, providing insights that could lead to the development of new medications.
  • Environmentally Friendly Options: As scientists seek more sustainable practices, understanding the synthesis and potential biocompatibility of such compounds is an area of interest that aligns with green chemistry initiatives.

In summary, the exploration of 2-[4-[1-[4-(1-carboxy-1-methyl-propoxy)phenyl]cyclohexyl]phenoxy]-2-methyl-butanoic acid showcases the intersection of complex organic chemistry and real-world therapeutic applications. With its diverse functional groups and potential biological activities, it serves as a prime candidate for ongoing research in medicinal chemistry.

Synonyms
clinofibrate
30299-08-2
Lipoclin
Clinofibrato
Clinofibratum
Clinofibrate [INN:JAN]
Clinofibratum [INN-Latin]
Clinofibrato [INN-Spanish]
S 8527
butanoic acid, 2,2'-[cyclohexylidenebis(4,1-phenyleneoxy)]bis[2-methyl-
Lipoclin (TN)
S-8527
BRN 2230067
0374EZJ8CU
DTXSID6046638
2-[4-[1-[4-(2-carboxybutan-2-yloxy)phenyl]cyclohexyl]phenoxy]-2-methylbutanoic acid
CLINOFIBRATE [MI]
MFCD00865769
CLINOFIBRATE [INN]
CLINOFIBRATE [JAN]
CLINOFIBRATE [MART.]
CLINOFIBRATE [WHO-DD]
DTXCID4026638
2,2'-(4,4'-Cyclohexylidenediphenoxy)-2,2'-dimethyldibutyric acid
2,2'-(Cyclohexylidenebis(p-phenyleneoxy))bis(2-methylbutyric acid)
2,2'-(Cyclohexylidenebis(4,1-phenyleneoxy))bis(2-methylbutanoic acid)
2,2'-Cyclohexane-1,1-diylbis(p-phenyleneoxy)bis(2-methylbutyric acid)
NCGC00167453-01
NCGC00167453-02
2,2'-Dimethyl-2,2'-(4,4'-cyclohexylidendiphenoxy)dibuttersaeure
Butanoic acid, 2,2'-(cyclohexylidenebis(4,1-phenyleneoxy))bis(2-methyl-
Butyric acid, 2,2'-cyclohexane-1,1-diylbis(p-phenyleneoxy)bis-(2-methyl-
Clinofibratum (INN-Latin)
Clinofibrato (INN-Spanish)
2,2'-((Cyclohexane-1,1-diylbis(4,1-phenylene))bis(oxy))bis(2-methylbutanoic acid)
2-(4-{1-[4-(1-carboxy-1-methylpropoxy)phenyl]cyclohexyl}phenoxy)-2-methylbutanoic acid
CLINOFIBRATE (MART.)
2,2'-(4,4'-Cyclohexylidenediphenoxy)-2,2'-dimethyldibutanoic Acid
CAS-30299-08-2
UNII-0374EZJ8CU
2-(4-(1-(4-(1-carboxy-1-methylpropoxy)phenyl)cyclohexyl)phenoxy)-2-methylbutanoic acid
1,1-bis(4'-(1''-carboxy-1''-methylpropoxy)phenyl)cyclohexane
butanoic acid, 2,2'-(cyclohexylidenebis(4,1-phenyleneoxy))bis(2-methyl)
Clinofibrate (JP18/INN)
SCHEMBL31290
MLS006010186
CHEMBL1897738
CHEBI:31412
HMS3656N09
BCP13269
Tox21_112457
s2664
AKOS015896391
Tox21_112457_1
AC-4728
CCG-269436
CS-6464
DB09006
NCGC00167453-03
AS-13842
HY-13528
SMR004701292
SY053083
C3100
SW220029-1
C74555
D01300
SBI-0654068.0001
SR-01000944983
Q4116993
SR-01000944983-1
BRD-A90625545-001-02-0
(2S,2'S)-2,2'-(4,4'-(cyclohexane-1,1-diyl)bis(4,1-phenylene))bis(oxy)bis(2-methylbutanoic acid)
1,1-Bis[4'-(1''-carboxy-1''-methylpropoxy)phenyl]cyclohexane; 2,2'-[Cyclohexylidenebis(4,1-phenyleneoxy)]bis[2-methyl-butanoic Acid; Lipoclin; S 8527;
2,2 inverted exclamation mark -[[Cyclohexane-1,1-diylbis(4,1-phenylene)]bis(oxy)]bis(2-methylbutanoic Acid)