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Tetryzoline

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Identification
Molecular formula
C13H16N2O3
CAS number
84-22-0
IUPAC name
2-[(3,4,5-trimethoxyphenyl)methyl]-4,5-dihydro-1H-imidazole
State
State

Tetryzoline is typically found as a solid powder at room temperature, though in practical applications, especially in medical use, it is often found in solution form, such as in eye drops for relief from redness.

Melting point (Celsius)
195.50
Melting point (Kelvin)
468.65
Boiling point (Celsius)
355.30
Boiling point (Kelvin)
628.45
General information
Molecular weight
305.37g/mol
Molar mass
305.3650g/mol
Density
1.1800g/cm3
Appearence

Tetryzoline appears as a white to yellowish crystalline powder. It may have a slightly characteristic odor. The compound can exist in various forms including in pharmaceutical preparations where it may be dissolved in a clear and colorless ophthalmic solution.

Comment on solubility

Solubility of 2-[(3,4,5-trimethoxyphenyl)methyl]-4,5-dihydro-1H-imidazole

The solubility of 2-[(3,4,5-trimethoxyphenyl)methyl]-4,5-dihydro-1H-imidazole can be considered quite intriguing due to the molecular structure and the presence of various functional groups.

Key points to consider regarding its solubility include:

  • Polar and Non-Polar Interactions: The compound contains several methoxy (-OCH3) groups which can enhance solubility in polar solvents due to effective dipole interactions.
  • Hydrophobic Regions: The presence of the phenyl ring may contribute to hydrophobic characteristics, making it less soluble in polar solvents but potentially more soluble in organic/non-polar solvents.
  • Solvent Type: Typically, compounds with similar structural features show increased solubility in solvents like ethanol or methanol, while showing limited solubility in water.
  • Temperature Dependency: Like many organic compounds, solubility can be impacted by temperature, where higher temperatures often lead to increased solubility.

In conclusion, the solubility of 2-[(3,4,5-trimethoxyphenyl)methyl]-4,5-dihydro-1H-imidazole is influenced by both the polar functional groups and the hydrophobic nature of the phenyl moiety. It is advisable to conduct specific solubility tests in various solvents to determine the most favorable conditions for dissolution.

Interesting facts

Facts About 2-[(3,4,5-Trimethoxyphenyl)methyl]-4,5-dihydro-1H-imidazole

This fascinating compound belongs to a class of organic compounds that showcase a rich structure and diverse potential applications. Here are some interesting aspects of 2-[(3,4,5-trimethoxyphenyl)methyl]-4,5-dihydro-1H-imidazole:

  • Structural Diversity: The presence of the imidazole ring provides a unique framework that is often found in various natural products and pharmaceutical compounds. Imidazoles are known for their role in medicinal chemistry.
  • Biological Activity: Compounds containing imidazole moieties have been studied for a wide range of biological activities. They often exhibit antimicrobial, antifungal, and even antitumor properties, which makes them valuable in drug design.
  • Functional Groups: The inclusion of trimethoxy groups in the phenyl ring enhances the compound's reactivity and solubility, which can influence its biological interactions and effectiveness.
  • Research Significance: This compound and its derivatives are of particular interest in the development of new therapeutics. Scientists are continually exploring their potential as anticancer agents and other therapeutic applications.
  • Synthesis Challenges: The synthesis of this compound may involve several steps, requiring careful consideration of reaction conditions to ensure the selectivity and yield of the desired product.

As a unique blend of structural elegance and potential therapeutic implications, 2-[(3,4,5-trimethoxyphenyl)methyl]-4,5-dihydro-1H-imidazole exemplifies the fascinating world of organic chemistry, where innovation and discovery continually intersect!

Synonyms
Phedrazine
101-30-4
2-[(3,4,5-trimethoxyphenyl)methyl]-4,5-dihydro-1H-imidazole
Ciba 2020
Phedracin
Phedracine
4,5-Dihydro-2-[(3,4,5-Trimethoxyphenyl)Methyl]-1H-Imidazole
Phedrazin [German]
Phedrazin
BRN 0245012
2-(3',4',5'-Trimethoxybenzyl)imidazoline
4-23-00-03366 (Beilstein Handbook Reference)
2-IMIDAZOLINE, 2-(3,4,5-TRIMETHOXYBENZYL)-
SCHEMBL10777223
DTXSID90143617
1H-Imidazole, 4,5-dihydro-2-((3,4,5-trimethoxyphenyl)methyl)-