Aminosalicylic Acid Phosphate | Solubility of Things

Identification

Molecular formula

C₁₂H₁₅NO₉P

CAS number

57846-28-1

IUPAC name

2-[[3,4-dihydroxy-5-(phosphonooxymethyl)tetrahydrofuran-2-yl]amino]benzoic acid

State

At room temperature, this compound is typically a crystalline solid.

Melting point (Celsius)

280.00

Melting point (Kelvin)

553.15

Boiling point (Celsius)

550.00

Boiling point (Kelvin)

823.15

General information

Molecular weight

347.23g/mol

Molar mass

347.2300g/mol

Density

1.5820g/cm³

Appearence

Aminosalicylic Acid Phosphate typically appears as an off-white to pale yellow crystalline powder. It is sparingly soluble in water and exhibits characteristic UV absorbance.

Comment on solubility

Solubility of 2-[[3,4-dihydroxy-5-(phosphonooxymethyl)tetrahydrofuran-2-yl]amino]benzoic acid

The solubility of the compound 2-[[3,4-dihydroxy-5-(phosphonooxymethyl)tetrahydrofuran-2-yl]amino]benzoic acid, C₁₂H₁₅NO₉P, is influenced by its unique structural features, which include both hydrophilic and hydrophobic components. This balance can lead to varying solubility characteristics depending on the solvent used.

Factors Affecting Solubility

Polarity: The presence of multiple hydroxyl (-OH) groups and a phosphono group enhances its polarity, suggesting higher solubility in polar solvents such as water.
Hydrogen Bonding: The ability to form hydrogen bonds due to hydroxyl groups can lead to increased solubility in aqueous solutions.
Electrostatic Interactions: The phosphono group can also engage in strong interactions with water molecules, contributing to solubility.

On the contrary, while 2-[[3,4-dihydroxy-5-(phosphonooxymethyl)tetrahydrofuran-2-yl]amino]benzoic acid is expected to exhibit good solubility in polar solvents, it may show limited solubility in non-polar solvents due to its complex structure and functional groups.

In summary, the solubility of this compound is characterized by:

High solubility in polar solvents
Potential low solubility in non-polar solvents

This solubility profile positions 2-[[3,4-dihydroxy-5-(phosphonooxymethyl)tetrahydrofuran-2-yl]amino]benzoic acid as a versatile compound in biochemical applications, particularly in environments where aqueous conditions prevail.

Interesting facts

Interesting Facts about 2-[[3,4-dihydroxy-5-(phosphonooxymethyl)tetrahydrofuran-2-yl]amino]benzoic acid

2-[[3,4-dihydroxy-5-(phosphonooxymethyl)tetrahydrofuran-2-yl]amino]benzoic acid is a fascinating compound that showcases the intersection of organic chemistry and biochemistry. Here are some intriguing aspects of this compound:

Biological Relevance: This compound contains a phosphonooxymethyl group, which plays a crucial role in biological systems, particularly in signaling pathways and metabolic processes.
Potential Therapeutic Applications: Due to its structural features, it may possess potential as a drug candidate, particularly in the treatment of diseases where phosphonate derivatives have demonstrated efficacy, such as cancer or viral infections.
Unique Structure: The presence of both a tetrahydrofuran ring and amino acid functionality indicates its capacity for complex interactions with biological molecules, enhancing its relevance in drug design.
Natural Product Inspirations: Compounds containing dihydroxy groups are often derived from natural products, indicating that this molecule could mimic or interact with biological targets akin to natural metabolites.
Research & Development: Due to its complex structure, the synthesis and characterization of this compound provide valuable insights into modern synthetic methods and the importance of phosphorus in organic compounds.

In summary, 2-[[3,4-dihydroxy-5-(phosphonooxymethyl)tetrahydrofuran-2-yl]amino]benzoic acid isn't just a chemical entity; it represents a rich tapestry of chemical innovation and biological significance. Its exploration could yield promising results in medicinal chemistry, thereby highlighting the importance of interdisciplinary research in advancing scientific knowledge.