Interesting facts
Interesting Facts about 2-[3-(Trifluoromethyl)anilino]pyridine-3-carboxylic Acid
This compound is a fascinating member of the pyridine derivatives, primarily known for its diverse applications in medicinal chemistry and pharmaceuticals. Here are some intriguing points about this compound:
- Trifluoromethyl Group: The presence of the trifluoromethyl group in its structure significantly enhances the compound's lipophilicity and biological activity, making it a valuable scaffold in drug design.
- Pharmacological Potential: Research indicates that compounds like this one may exhibit anticancer, anti-inflammatory, and antiviral properties, which highlights their potential in therapeutic applications.
- Synthetic Versatility: Its synthesis often involves various methodologies, including nucleophilic substitutions and coupling reactions, which can be adapted for the design of more complex molecules in medicinal chemistry.
- Binding Profile: The distinct structure allows it to interact with biological targets, aiding the development of selective inhibitors or modulators, particularly in cancer therapy.
- Research Relevance: Studies on this compound contribute to a broader understanding of structure-activity relationships (SAR) in drug development, providing insights into how molecular modifications impact pharmacological effects.
In summary, 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid exemplifies the complexity and potential of small molecular compounds in the realm of medicinal chemistry. As science advances, compounds like these often serve as building blocks for innovative treatments and therapies, representing the bridge between basic research and practical application in healthcare.
Synonyms
niflumic acid
4394-00-7
Landruma
Nifluril
Forenol
Acido niflumico
Nifluminic acid
Acide niflumique
Niflugel
2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylic acid
UP 83
Acide niflumique [INN-French]
Acido niflumico [INN-Spanish]
Acidum niflumicum [INN-Latin]
Acidum niflumicum
Acide niflumique [French]
Acido niflumico [Italian]
Niflamol
2-(3-(Trifluoromethyl)anilino)nicotinic acid
2-(3-(Trifluoromethyl)-phenyl)aminonicotinic acid
2-[3-(Trifluoromethyl)anilino]nicotinic acid
Niflugel (TN)
3-Pyridinecarboxylic acid, 2-[[3-(trifluoromethyl)phenyl]amino]-
2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid
2-(3-Trifluoromethylanilino)nicotinic Acid
2-((3-(Trifluoromethyl)phenyl)amino)nicotinic acid
Niflumic acid (INN)
CCRIS 5740
SC 1332
Lopac-N-0630
Actol, analgesic
EINECS 224-516-2
4U5MP5IUD8
MFCD00010569
NSC-758196
BRN 0489360
Niflumic acid [INN:BAN:DCF]
DTXSID1023368
UP-83
2-(alpha,alpha,alpha-Trifluoro-m-toluidino)nicotinic acid
2-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}NICOTINIC ACID
2-(3-(Trifluoromethyl)phenylamino)nicotinic acid
Aza-2 dimethyl-2',3' (tetrazolyl-5)-6 diphenylamino [French]
3-Pyridinecarboxylic acid, 2-((3-(trifluoromethyl)phenyl)amino)-
NIFLUMIC ACID [MI]
2-[(3-TRIFLUOROMETHYL)PHENYL]AMINO-3-PYRIDINE-CARBOXYLIC ACID
NIFLUMIC ACID [INN]
Aza-2 dimethyl-2',3' (tetrazolyl-5)-6 diphenylamino
MLS000069713
NIFLUMIC ACID [MART.]
DTXCID903368
NIFLUMIC ACID [WHO-DD]
NFL
CHEBI:34888
5-22-13-00598 (Beilstein Handbook Reference)
NIFLUMIC ACID [EP IMPURITY]
NIFLUMIC ACID [EP MONOGRAPH]
Niflumic Acid-d5
NSC 758196
NCGC00015724-10
Nicotinic acid, 2-(alpha,alpha,alpha-trifluoro-m-toluidino)-
Niflumate
SMR000058199
CAS-4394-00-7
Nicotinic acid, 2-(.alpha.,.alpha.,.alpha.-trifluoro-m-toluidino)-
2-(3-[Trifluoromethyl]anilino)nicotinic acid
Acid, Niflumic
NIFLUMIC ACID (MART.)
Niflumic Acid-d5 (Major)
Acide niflumique (INN-French)
Acido niflumico (INN-Spanish)
Acidum niflumicum (INN-Latin)
2-[3-(Trifluoromethyl)anilino]-3-pyridinecarboxylic acid
2-[[3-(trifluoromethyl)phenyl]amino]pyridine-3-carboxylic acid
NIFLUMIC ACID (EP IMPURITY)
NIFLUMIC ACID (EP MONOGRAPH)
1794811-58-7
SR-01000000231
2-(3-Trifluoromethyl-phenylamino)-nicotinic acid
UNII-4U5MP5IUD8
2-(3-(Trifluoromethyl)anilino)-3-pyridinecarboxylic acid
2-((3-(trifluoromethyl)phenyl)amino)pyridine-3-carboxylic acid
niflumic-acid
ni-flumic acid
Prestwick_890
Spectrum_001353
1td7
2-[[3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid
Opera_ID_1746
Prestwick0_000255
Prestwick1_000255
Prestwick2_000255
Prestwick3_000255
Spectrum2_000794
Spectrum3_001485
Spectrum4_000043
Spectrum5_001216
Niflumic acid (Standard)
Niflumic acid (Hit 16)
N 0630
2-[(3-Trifluoromethylphenyl)amino]nicotinic Acid
CBiol_001828
Lopac0_000845
SCHEMBL24706
BSPBio_000070
BSPBio_001393
BSPBio_003069
KBioGR_000113
KBioGR_000505
KBioSS_000113
KBioSS_001833
MLS001076327
CHEMBL63323
DivK1c_000277
SPECTRUM1502015
SPBio_000928
SPBio_002289
BPBio1_000078
GTPL2439
BDBM85507
HMS500N19
HY-B0493R
KBio1_000277
KBio2_000113
KBio2_001833
KBio2_002681
KBio2_004401
KBio2_005249
KBio2_006969
KBio3_000225
KBio3_000226
KBio3_002569
M01AX02
M02AA17
NINDS_000277
2-[(3-Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic Acid
Bio1_000114
Bio1_000603
Bio1_001092
Bio2_000113
Bio2_000593
HMS1361F15
HMS1568D12
HMS1791F15
HMS1921D12
HMS1989F15
HMS2090D19
HMS2095D12
HMS2234F11
HMS3262J11
HMS3374H01
HMS3402F15
HMS3649A08
HMS3656P14
HMS3712D12
HMS3885I03
Pharmakon1600-01502015
HY-B0493
NSC_4488
UWC81158
Tox21_110206
Tox21_500845
BBL003619
CCG-40157
DL-457
NSC758196
s3018
STK803109
AKOS000519590
Tox21_110206_1
AC-2652
DB04552
FN26214
GS-3202
LP00845
SDCCGSBI-0050821.P004
IDI1_000277
IDI1_033863
NCGC00015724-01
NCGC00015724-02
NCGC00015724-03
NCGC00015724-04
NCGC00015724-05
NCGC00015724-06
NCGC00015724-07
NCGC00015724-08
NCGC00015724-09
NCGC00015724-11
NCGC00015724-12
NCGC00015724-13
NCGC00015724-14
NCGC00015724-17
NCGC00015724-29
NCGC00023636-03
NCGC00023636-04
NCGC00023636-05
NCGC00023636-06
NCGC00023636-07
NCGC00023636-08
NCGC00023636-09
NCGC00261530-01
SY002411
CAS_4394-00-7
SBI-0050821.P003
2(3'-trifluormethylanilino)-nicotinic acid
AB00052255
EU-0100845
NS00010059
SW197011-3
T2353
EN300-17360
D08275
H10042
M02156
AB00052255-17
AB00052255_18
AB00052255_19
2-((3-(Trifluoromethyl)phenyl)amino)nicotinicacid
Q304285
SR-01000000231-2
SR-01000000231-5
SR-01000000231-6
BRD-K98763141-001-04-3
BRD-K98763141-001-06-8
BRD-K98763141-001-17-5
BRD-K98763141-001-29-0
BRD-K98763141-001-30-8
SR-01000000231-11
Z56922127
Niflumic acid, European Pharmacopoeia (EP) Reference Standard
224-516-2
Solubility of 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid
When investigating the solubility of the compound 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid (C16H11F3N2O2), several important factors contribute to its behavior in various solvents:
In summary, while 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid may exhibit reasonable solubility in organic solvents, its behavior in water will largely depend on the balance of its polar and nonpolar characteristics, as well as the conditions of the solution. As such, it may show limited solubility in water but enhanced solubility in suitable organic solvents.