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Brinzolamide

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Identification
Molecular formula
C12H21N3O8S3
CAS number
138890-62-7
IUPAC name
2-(3-methoxyphenyl)-4-(methylamino)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide
State
State

Brinzolamide is typically a solid at room temperature.

Melting point (Celsius)
131.50
Melting point (Kelvin)
404.65
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
383.50g/mol
Molar mass
383.4950g/mol
Density
1.9000g/cm3
Appearence

Brinzolamide appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 2-(3-methoxyphenyl)-4-(methylamino)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide

The solubility of the compound 2-(3-methoxyphenyl)-4-(methylamino)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide (C12H21N3O8S3) can be quite complex due to its multi-functional structure. This compound features both hydrophilic (water-loving) and hydrophobic (water-fearing) characteristics, which greatly influences its solubility profile.

Here are some key points regarding its solubility:

  • Hydrophobic Regions: The presence of thieno[3,2-e]thiazine and methoxyphenyl groups can contribute to hydrophobic interactions, potentially leading to lower solubility in aqueous environments.
  • Hydrophilic Groups: The sulfonamide functional group is known to enhance solubility in polar solvents, potentially increasing the compound's solubility in water.
  • pH Dependency: The solubility may vary significantly with pH, as the ionization of the sulfonamide and amino groups could influence solubility, making it more soluble in basic conditions where ionization is encouraged.

In summary, while 2-(3-methoxyphenyl)-4-(methylamino)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide may exhibit limited solubility in non-polar solvents, its multi-functional groups provide opportunities for increased solubility through polar interactions. Understanding this solubility profile is crucial for its applications in pharmaceutical formulations.

Interesting facts

Interesting Facts about 2-(3-methoxyphenyl)-4-(methylamino)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide

This complex compound is intriguing due to its layered structure and multifaceted applications in the field of medicinal chemistry. Its unique arrangement includes a thieno[3,2-e]thiazine ring, which contributes to its biological activity. Here are some interesting points:

  • Microscopic Architecture: The compound features a sophisticated arrangement of atoms, characterized by thiazine and sulfonamide moieties, which are known for their potent pharmacological properties.
  • Pharmacological Significance: Compounds like this are often investigated for their potential as therapeutics. Sulfonamides, in particular, have a historical reputation for their antimicrobial properties.
  • Structural Diversity: The presence of the methoxyphenyl group and methylamino moiety allows for a wide range of modifications, making this compound a candidate for further derivatization and optimization in drug development.
  • Interdisciplinary Applications: The reactivity of the sulfonamide functional group opens pathways for further interaction with biological systems, making it a focal point for research in both organic synthesis and drug discovery.

As a quote from renowned chemist Linus Pauling suggests, “The best way to have a good idea is to have a lot of ideas.” Exploring the myriad potential this compound holds could very well lead to innovative solutions in medicine.

In summary, 2-(3-methoxyphenyl)-4-(methylamino)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide is more than just a chemical; it's a gateway to understanding complex biochemical interactions and developing effective therapeutic agents.

Synonyms
2-(3-Methoxyphenyl)-4-(methylamino)-1,1-dioxo-1,2,3,4-tetrahydro-1lambda~6~-thieno[3,2-e][1,2]thiazine-6-sulfonamide
933766-92-8
DTXSID30870253