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Amoxapine

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Identification
Molecular formula
C17H16ClNO
CAS number
14028-44-5
IUPAC name
2-(3-chlorobenzo[b][1]benzothiepin-5-yl)oxy-N,N-dimethyl-ethanamine
State
State

At room temperature, Amoxapine is in a solid state. This tricyclic antidepressant is stable under standard conditions and is usually handled in powdered form for pharmaceutical applications.

Melting point (Celsius)
158.00
Melting point (Kelvin)
431.15
Boiling point (Celsius)
525.80
Boiling point (Kelvin)
798.95
General information
Molecular weight
314.83g/mol
Molar mass
314.8310g/mol
Density
1.2700g/cm3
Appearence

Amoxapine is typically observed as an off-white to pale yellow solid. It may appear as a crystalline powder form with slight variations in color due to purity or processing.

Comment on solubility

Solubility of 2-(3-chlorobenzo[b][1]benzothiepin-5-yl)oxy-N,N-dimethyl-ethanamine

The solubility of 2-(3-chlorobenzo[b][1]benzothiepin-5-yl)oxy-N,N-dimethyl-ethanamine, with the chemical formula C17H16ClNO, presents some notable characteristics:

  • Solvent Compatibility: This compound likely demonstrates solubility in organic solvents due to its hydrophobic aromatic structure combined with polar functional groups.
  • Temperature Influence: As with many organic compounds, increased temperature may enhance solubility, allowing for greater interaction with solvent molecules.
  • Potential for Formulation: Its solubility profile could be advantageous for pharmaceutical formulations, making it feasible to create effective delivery systems.
  • Chlorine's Role: The presence of chlorine often affects the overall solubility, generally exhibiting lower water solubility but enhancing solubility in organic media.

To summarize, while specific quantitative solubility data for this compound may be limited, its expected behavior in various solvents can significantly influence its application in different fields. Always consider environmental conditions and solvent choice when evaluating solubility characteristics!

Interesting facts

Interesting Facts about 2-(3-chlorobenzo[b][1]benzothiepin-5-yl)oxy-N,N-dimethyl-ethanamine

This compound, known by its lengthy and complex name, serves as a fascinating example in the field of medicinal chemistry. Here are some noteworthy points:

  • Medicinal Relevance: The structure of this compound suggests potential activity as a pharmacological agent. Compounds featuring benzothiepin structures are known for their diverse biological activities, often related to neuromodulatory effects.
  • Chlorine Substitution: The presence of chlorine in the aromatic ring not only enhances the stability of the compound but may also improve lipophilicity, facilitating biological interaction with certain receptors in the body.
  • Dimethylamino Group: The N,N-dimethyl functional group is significant, commonly enhancing the compound's interaction with neurotransmitter systems, likely affecting mood and behavior.
  • Synthetic Challenges: Synthesis of this compound can be complex due to the multifaceted nature of its structure, often requiring specialized techniques to ensure the desired selectivity and yield in reactions.
  • Regulatory Interest: Given its structure, compounds like this one are often studied for their potential implications in pharmacology and toxicology, necessitating thorough evaluation under guidelines of regulatory agencies.

Overall, 2-(3-chlorobenzo[b][1]benzothiepin-5-yl)oxy-N,N-dimethyl-ethanamine not only highlights the intricate interplay between chemistry and pharmacology but also represents an exciting avenue for future research into new therapeutic agents. As the exploration of such compounds continues, who knows what new discoveries await in their applications?

Synonyms
zotepine
26615-21-4
Nipolept
Lodopin
Zotepina
Zoleptil
Zotepinum
Setous
Compound-4
Zotepina [Spanish]
Zotepin
Zotepinum [INN-Latin]
Zotepina [INN-Spanish]
Ethanamine, 2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethyl-
2-Chloro-11-(2-(dimethylamino)ethoxy)dibenzo(b,f)thiepin
Zotepine [INN:BAN:JAN]
U29O83JAZW
2-Chlor-11-(2-dimethylaminoaethoxy)-dibenzo(b,f)-thiepin
Setous (TN)
BRN 1435710
DTXSID9023756
CHEBI:32316
ZOTEPINE [INN]
ZOTEPINE [JAN]
ZOTEPINE [MI]
ZOTEPINE [MART.]
ZOTEPINE [WHO-DD]
2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethylethanamine
2-Chloro-11-(2-dimethylaminoethoxy)-dibenzo(b,f)thiepine
CHEMBL285802
DTXCID603756
2-((8-Chlorodibenzo(b,f)thiepin-10-yl)oxy)-N,N-dimethylethanamine
2-((8-Chlorodibenzo(b,f)thiepin-10-yl)oxy)-N,N-dimethylethylamine
2-(3-chlorobenzo[b][1]benzothiepin-5-yl)oxy-N,N-dimethylethanamine
2-Chlor-11-(2-dimethylaminoaethoxy)-dibenzo(b,f)-thiepin [German]
5-17-04-00588 (Beilstein Handbook Reference)
NCGC00182081-02
Zotepinum (INN-Latin)
Zotepina (INN-Spanish)
DIBENZO(b,f)THIEPIN, 2-CHLORO-11-(2-(DIMETHYLAMINO)ETHOXY)-
Ethanamine, 2-((8-chlorodibenzo(b,f)thiepin-10-yl)oxy)-N,N-dimethyl-
ZOTEPINE (MART.)
Lodopin; Losizopilon; Nipolept; Setous; Zoleptil;
2-(8-chlorobenzo[b][1]benzothiepin-6-yl)oxy-N,N-dimethylethanamine
C18H18ClNOS
2-(3-chloranylbenzo[b][1]benzothiepin-5-yl)oxy-N,N-dimethyl-ethanamine
CAS-26615-21-4
UNII-U29O83JAZW
Engramon
Majorpin
2-((8-chlorodibenzo[b,f]thiepin-10-yl)oxy)-N,N-dimethylethanamine
2-(8-chlorobenzo(b)(1)benzothiepin-6-yl)oxy-N,N-dimethylethanamine
Zoleptil 25
Zoleptil 50
Zoleptil 100
MFCD00868143
Zotepine (Standard)
2-chloro-11-(2-dimethylaminoethoxy)dibenzo(b,f)thiepine
Zotepine (JAN/INN)
2-[(8-chlorodibenzo[b,f]-thiepin-10-yl)oxy]-N,N-dimethylethanamine
GTPL103
SCHEMBL114409
BDBM35255
HDOZVRUNCMBHFH-UHFFFAOYSA-
N05AX11
HMS3713E06
BCP06661
Tox21_113135
HB1778
AKOS005066198
Tox21_113135_1
CCG-220422
DB09225
FR-1314
FZ37994
HY-103093R
NCGC00182081-03
NCGC00182081-04
AS-12557
DA-68870
HY-103093
CS-0024101
NS00002476
D01321
F87263
EN300-18568537
L000902
Q226905
SR-01000872710
SR-01000872710-1
BRD-K64557645-001-02-4
2-[(8-Chlorodibenzo(Z)[b,f]thiepin- 10-yl)oxy]-N,N-dimethylethanamine
[2-({6-chloro-2-thiatricyclo[9.4.0.0,3,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-9-yl}oxy)ethyl]dimethylamine
1200591-33-8
662-775-7
InChI=1/C18H18ClNOS/c1-20(2)9-10-21-16-11-13-5-3-4-6-17(13)22-18-8-7-14(19)12-15(16)18/h3-8,11-12H,9-10H2,1-2H3
ZOT