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Thiamine diphosphate

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Identification
Molecular formula
C12H18N4O7P2
CAS number
59-43-8
IUPAC name
2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-thiazol-3-ium-5-yl]ethyl dihydrogen phosphate
State
State
Thiamine diphosphate is typically found as a solid at room temperature. As a white crystalline powder, it remains stable under standard laboratory conditions. However, it is essential to store it away from direct light and moisture to prevent degradation.
Melting point (Celsius)
248.00
Melting point (Kelvin)
521.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
379.28g/mol
Molar mass
379.2750g/mol
Density
1.4000g/cm3
Appearence

Thiamine diphosphate typically appears as a white crystalline or amorphous powder. It is odorless and has a slightly bitter taste. It is stable under normal conditions but can degrade under prolonged exposure to light. It is water-soluble, which means it can readily dissolve in water, enhancing its appearance as a powder when dried.

Comment on solubility

Solubility of 2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-thiazol-3-ium-5-yl]ethyl dihydrogen phosphate

The solubility of 2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-thiazol-3-ium-5-yl]ethyl dihydrogen phosphate (C12H18N4O7P2) can be influenced by several factors due to its complex structure. Here are some key points to consider:

  • Polarity - The presence of multiple functional groups such as phosphate and amine may enhance its interaction with polar solvents like water, indicating potential solubility.
  • Hydrogen Bonding - The ability of the molecule to donate and accept hydrogen bonds can significantly affect solubility. Compounds capable of forming extensive hydrogen bonds with water molecules are usually more soluble.
  • Temperature Dependency - Like many chemical compounds, solubility may vary with temperature; generally, increased temperature can lead to increased solubility in most solvents.
  • pH Sensitivity - The ionic state of the dihydrogen phosphate group may vary with changing pH levels, which can either enhance or diminish solubility under different conditions.

In conclusion, the solubility of this compound is determined by a combination of its molecular structure, the solvent properties, and environmental conditions. Understanding these aspects is crucial to predict its behavior in various chemical settings.

Interesting facts

Exploring 2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-thiazol-3-ium-5-yl]ethyl dihydrogen phosphate

This fascinating compound plays a unique role in the field of chemistry, as it showcases the distinct combination of heterocyclic structures and phosphate groups. Here are some interesting aspects to consider:

  • Multifunctional Application: Compounds containing both thiazole and pyrimidine rings have been extensively studied for their biological activities, including antimicrobial and anti-inflammatory properties.
  • The Importance of Phosphate Groups: Dihydrogen phosphate moieties are pivotal in biochemistry, contributing to the biochemistry of nucleic acids and energy transfer processes, fundamentally impacting ATP (adenosine triphosphate) function.
  • Structural Intricacies: The presence of multiple functional groups allows for intricate interactions with biological systems, often leading to altered pharmacological activities, making them valuable in drug design.

Furthermore, as a scientist or student exploring this compound, consider how its synthetic pathway may influence specific characteristics and functionality. As the renowned chemist Linus Pauling once said, "The nature of a chemical bond is determined by the properties of the participating atoms." This highlights the critical relationship between molecular structure and function.

In summary, the study of 2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-thiazol-3-ium-5-yl]ethyl dihydrogen phosphate not only offers a glimpse into complex chemical interactions but also emphasizes the broader implications of heterocycle chemistry in medicinal applications. Its evolving role in research continues to inspire chemists striving to uncover new therapeutic avenues.

Synonyms
thiamine monophosphate
thiamin phosphate
Thiamine phosphate
10023-48-0
thiamin monophosphate
ThMP
Phosphothiaminum
Tiamina monofosfato
3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-[2-(phosphonooxy)ethyl]thiazolium
CHEBI:9533
3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-5-[2-(phosphonooxy)ethyl]-1,3-thiazol-3-ium
2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethyl dihydrogen phosphate
Aneurine monophosphate
Thiamin dihydrogenphosphate
Aneurin-monophosphorsaeureester
3-((4-Amino-2-methylpyrimidin-5-yl)methyl)-4-methyl-5-(2-(phosphonooxy)ethyl)thiazol-3-ium
TPS
NCGC00164500-01
3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-4-methyl-5-(2-(phosphonooxy)ethyl)thiazolium
bmse000699
SCHEMBL94444
C12H18N4O4PS
GTPL4580
CHEMBL1236378
DTXSID6048389
BDBM92961
HZSAJDVWZRBGIF-UHFFFAOYSA-O
AKOS030242384
NCGC00164500-02
NS00022956
C01081
Q60998707