Thiamine hydrochloride | Solubility of Things

Identification

Molecular formula

C₁₂H₁₈Cl₂N₄OS

CAS number

67-03-8

IUPAC name

2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-thiazol-3-ium-5-yl]ethanol;chloride;hydrochloride

State

At room temperature, thiamine hydrochloride is a solid which often appears as a crystalline powder. It is commonly used in its solid form in various pharmaceutical applications.

Melting point (Celsius)

246.00

Melting point (Kelvin)

519.00

Boiling point (Celsius)

0.00

Boiling point (Kelvin)

0.00

General information

Molecular weight

337.27g/mol

Molar mass

337.2730g/mol

Density

1.3000g/cm³

Appearence

Thiamine hydrochloride appears as a colorless crystalline powder. It is odorless or may have a slight characteristic odor and has a salty taste. When exposed to air, it tends to absorb moisture, demonstrating its hygroscopic nature.

Comment on solubility

Solubility of 2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-thiazol-3-ium-5-yl]ethanol;chloride;hydrochloride

The solubility of the compound with the chemical formula C₁₂H₁₈Cl₂N₄OS can be influenced by several factors, including its ionic character and the presence of functional groups. Overall, this compound is expected to exhibit the following solubility characteristics:

High Solubility in Water: Due to the presence of the hydrochloride form and various polar functional groups, this compound is likely to be soluble in aqueous environments.
Solubility in Organic Solvents: While the degree of solubility in organic solvents can vary, the compound may show limited solubility in non-polar solvents due to its polar characteristics.
Influence of pH: The solubility may also be affected by the pH of the solution, especially considering the ionic nature of the chloride and hydrochloride forms, which may enhance solubility in acidic conditions.
Temperature Effect: Typically, an increase in temperature can lead to increased solubility for many compounds, and this one may follow that trend.

In summary, the solubility of this compound is substantially governed by its ionic properties and functional groups, facilitating a high degree of solubility in aqueous solutions, while exhibiting variable solubility in organic solvents. As always, it is advisable to conduct empirical solubility tests for precise determination.

Interesting facts

Interesting Facts about 2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-thiazol-3-ium-5-yl]ethanol;chloride;hydrochloride

This unique compound, known for its complex structure, shows immense promise in various fields of research, especially in medicinal chemistry. Here are some engaging aspects of this compound:

Pharmaceutical Applications: The presence of a pyrimidine ring in the structure suggests potential activity as an antimicrobial agent, making it a candidate for further investigation in drug development.
Thiazole Chemistry: The thiazole component is notable for its ability to participate in a range of chemical reactions, further broadening the versatility of this compound in synthetic organic chemistry.
Amine Functional Group: The amine group in the structure can form hydrogen bonds, which potentially enhances solubility in physiological conditions, a key characteristic for any therapeutic compound.
Research Interest: Its intricate design has sparked interest among researchers looking into targeted therapies, particularly in combating resistant strains of bacteria or viruses.
Multi-functional Potential: The number of functional groups present in this compound indicates its ability to interact with various biological targets, which is essential for the development of multi-targeted drugs.

As the famous chemist Marie Curie once said, “Nothing in life is to be feared, it is only to be understood.” This compound reflects that principle, inviting scientists to delve deeper into its properties and potential.

In summary, the structural complexity and inherent functional diversity of 2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-thiazol-3-ium-5-yl]ethanol;chloride;hydrochloride highlight its significant potential in advancing chemical and pharmaceutical sciences.

Synonyms

THIAMINE HYDROCHLORIDE

67-03-8

Thiamine HCL

Aneurine hydrochloride

Clotiamina

Eskaphen

Vitamin B1 hydrochloride

Berin

Betalin S

Thiamine chloride hydrochloride

Thiamine dichloride

Begiolan

Bethiazine

Bevitine

Bithiamin

Thiadoxine

Tiamidon

Tiaminal

Vitaneuron

Beatine

Bedome

Benerva

Bequin

Beuion

Bevitex

Bivatin

Bivita

Eskapen

Slowten

Thiamol

Thiavit

Biuno

Hybee

Apate drops

Thiaminum hydrochloricum

vitamin B1

thiamine(2+) dichloride

Thiamin hydrochloride

Metabolin

Thiaminal

Trophite

Vinothiam

Betabion hydrochloride

Bewon

Lixa-beta

Thiamin chloride

Vetalin S

FEMA No. 3322

Thiamin dichloride

Thiaminium chloride

Betaxin

Usaf cb-20

MFCD00012780

Vitamin B hydrochloride

Thiaminium chloride hydrochloride

Thiamine monohydrochloride

Thiamine, monohydrochloride

NSC-36226

Betabion

Biamine

thymine hydrochloride

CCRIS 1906

Vitamin b(sub 1) hydrochloride

3-((4-amino-2-methylpyrimidin-5-yl)methyl)-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride hydrochloride

DTXSID0040622

UNII-M572600E5P

CHEBI:49105

Thiamine, hydrochloride

Thiamine (hydrochloride)

EINECS 200-641-8

NSC 36226

M572600E5P

Thiamine HCl (Vitamin B1)

Vitamin B1 (Thiamine HCl)

AI3-18993

67-03-8 (HCl salt)

DTXCID8020622

Thiamine hydrochloride [USP:JAN]

Thiamine Hydrochloride (Vitamin B1)

CAS-67-03-8

NCGC00017013-01

NSC36226

2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol chloride hydrochloride

2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol;chloride;hydrochloride

3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride hydrochloride

Thiamine hydrochloride 10 microg/mL in Acetonitrile

Thiamine chloride hydrochloride;Vitamin B1 hydrochloride

Thiamine hydrochloride (USP:JAN)

THD

THIAMINE HYDROCHLORIDE (MART.)

THIAMINE HYDROCHLORIDE [MART.]

THIAMINE HYDROCHLORIDE (USP-RS)

THIAMINE HYDROCHLORIDE [USP-RS]

SMR000875246

THIAMINE HYDROCHLORIDE (EP IMPURITY)

THIAMINE HYDROCHLORIDE [EP IMPURITY]

THIAMINE HYDROCHLORIDE (EP MONOGRAPH)

THIAMINE HYDROCHLORIDE [EP MONOGRAPH]

THIAMINE HYDROCHLORIDE (USP MONOGRAPH)

THIAMINE HYDROCHLORIDE [USP MONOGRAPH]

vitamin Bl

Vitamin B1 hydrochloride (VAN)

Vitamin b(sup1)

3-((4-azaniumyl-2-methylpyrimidin-5-yl)methyl)-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium dichloride

3-[(4-azaniumyl-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium dichloride

Prestwick_441

Thiamio hydrochloridum

Thiamini hydrochloridum

Thiamine HCL (TN)

Vitamin B1hydrochloride

Thiazolium, hydrochloride

VITAMIN B1 [FHFI]

Thiazolium, monohydrochloride

SCHEMBL41101

MLS001332447

MLS001332448

Thiamine hydrochloride (USP)

Thiamine for system suitability

Thiamine chloride, hydrochloride

CHEMBL1200941

HY-N0680R

Vitamin B1 Hydrochloride Hydrate

Thiamine, chloride, hydrochloride

HMS1569P04

THIAMINE HYDROCHLORIDE [MI]

BCP27971

HY-N0680

Thiamine (hydrochloride) (Standard)

THIAMINE HYDROCHLORIDE [FCC]

Tox21_110736

s3211

Thiamine hydrochloride, p.a., 98%

THIAMINE HYDROCHLORIDE [VANDF]

AKOS015905506

THYMINE HYDROCHLORIDE [WHO-DD]

CCG-220677

Chloride-hydrochloride salt of thiamine

CS-8164

FT28200

SB57886

THIAMINE HYDROCHLORIDE [WHO-DD]

THIAMINE HYDROCHLORIDE [WHO-IP]

THIAMINUM HYDROCHLORICUM [HPUS]

Thiamine chloride hydrochloride (JP17)

NCGC00017013-02

2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-5-yl}ethan- 1-ol, chloride, chloride

3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazolium chloride monohydrochloride

AS-14151

SY010871

Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl- chloride, monohydrochloride

DB-054984

THIAMINE HYDROCHLORIDE [ORANGE BOOK]

Thiamine hydrochloride, >=98%, FCC, FG

NS00079086

T0181

THIAMINE CHLORIDE HYDROCHLORIDE [JAN]

THIAMINI HYDROCHLORIDUM [WHO-IP LATIN]

D02094

EN300-258109

Thiamine Hydrochloride (B1), analytical standard

THIAMINE CHLORIDE, HYDROCHLORIDE [WHO-IP]

Thiamine hydrochloride, tested according to Ph.Eur.

Q27121486

Thiamine hydrochloride, reagent grade, >=99% (HPLC)

Thiamine hydrochloride, SAJ special grade, >=98.5%

F0001-2415

F2173-0852

Thiamine hydrochloride, meets USP testing specifications

Z1954805523

WLN: T6N CNJ B1 DZ E1- AT5K CSJ D2Q E1 &Q &G &GH

Thiamine hydrochloride, 99% (dry wt.), may cont. up to 5% water

Thiamine Hydrochloride (Vitamin B1) 1.0 mg/ml in Methanol (as free base)

Thiamine hydrochloride, European Pharmacopoeia (EP) Reference Standard

Thiamine hydrochloride, United States Pharmacopeia (USP) Reference Standard

3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-chloridethiazolium

Thiamine for system suitability, European Pharmacopoeia (EP) Reference Standard

Thiamine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

THIAZOLIUM,3-[(4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL]-5-(2-HYDROXYETHYL)-4-METHYL-

200-641-8

3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-m- ethylthiazolium chloride, monohydrochloride

3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-c hloridethiazolium hydrochloride ;Vitamin B1 hydrochloride

3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium hydrochloride chloride

Thiamine hydrochloride, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture

Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-m- ethyl, chloride, monohydrochloride

Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-, chloride, hydrochloride (1:1:1)

Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-, chloride, monohydrochloride