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Fenamic acid

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Identification
Molecular formula
C8H5Cl3O2
CAS number
3402-08-4
IUPAC name
2-(2,3,6-trichlorophenyl)acetic acid
State
State

At room temperature, 2-(2,3,6-trichlorophenyl)acetic acid is typically found in a solid state.

Melting point (Celsius)
141.50
Melting point (Kelvin)
414.70
Boiling point (Celsius)
362.50
Boiling point (Kelvin)
635.60
General information
Molecular weight
221.49g/mol
Molar mass
221.4970g/mol
Density
1.6097g/cm3
Appearence

2-(2,3,6-trichlorophenyl)acetic acid appears as a white crystalline solid. It is usually odorless and has a bitter taste. The crystals are typically fine and can exhibit different crystalline forms depending on the purification method used.

Comment on solubility

Solubility of 2-(2,3,6-trichlorophenyl)acetic acid

2-(2,3,6-trichlorophenyl)acetic acid is a compound that exhibits notable solubility characteristics, influenced by its chemical structure. Understanding its solubility can be crucial for applications in various fields, including pharmaceuticals and agrochemicals.

Key Solubility Insights

  • Polar Characteristics: The presence of the –COOH (carboxylic acid) functional group enhances the compound's ability to interact with polar solvents, such as water.
  • Chlorine Substituents: The trichlorophenyl moiety can significantly affect solubility. Chlorine atoms can increase hydrophobicity, thus potentially reducing solubility in polar solvents.
  • Solvent Influence: 2-(2,3,6-trichlorophenyl)acetic acid is expected to show higher solubility in organic solvents compared to aqueous environments. Solvents like ethanol or acetone may dissolve the compound more adequately due to their polar-aprotic nature.

In summary, while 2-(2,3,6-trichlorophenyl)acetic acid demonstrates some degree of solubility in polar solvents due to its acidic functional group, the overall solubility profile is tempered by the presence of chlorine substituents, which promote hydrophobic interactions. This balance makes the compound particularly interesting for study in various solvent interfaces.

Interesting facts

Interesting Facts about 2-(2,3,6-trichlorophenyl)acetic acid

2-(2,3,6-trichlorophenyl)acetic acid is a fascinating compound that holds significant importance in various fields of chemistry and pharmacology. Here are some interesting aspects of this unique acid:

  • Pharmaceutical Relevance: This compound is often studied for its role as a potential anti-inflammatory and analgesic agent, similar to common analgesics used in pain management.
  • Synthetic Utility: It serves as an important intermediate in the synthesis of several pharmaceuticals, making it a compound of interest in medicinal chemistry.
  • Chlorinated Phenyl Moiety: The presence of the trichlorophenyl group significantly alters the chemical properties, enhancing the compound's bioactivity and molecular interactions.
  • Environmental Impact: Due to its chlorine content, its degradation products and stability in environmental systems can raise concerns, necessitating studies into its ecological footprint.
  • Analytical Techniques: Researchers often employ sophisticated methods like chromatography and spectroscopy to analyze the compound’s structure and purity, revealing the complexities in its chemical behavior.
  • Reaction Pathways: Understanding the reactivity of this compound can lead to discoveries in synthetic methodologies and the development of new chemical processes.

Overall, 2-(2,3,6-trichlorophenyl)acetic acid exemplifies how a single compound can bridge multiple domains, including medicine, environmental science, and synthetic chemistry. By exploring its features, scientists can unlock new avenues for research and application.

Synonyms
Chlorfenac
Fenac
85-34-7
Kanepar
Fenae
Tri-fen
2-(2,3,6-trichlorophenyl)acetic acid
2,3,6-TRICHLOROPHENYLACETIC ACID
Trifene
Tri fene
Tri-fene
2,3,6-Trichlorobenzeneacetic acid
Acetic acid, (2,3,6-trichlorophenyl)-
Benzeneacetic acid, 2,3,6-trichloro-
Caswell No. 882
Chlorfenac [BSI:ISO]
2,3,6-Trichlorphenylessigsaeure
(2,3,6-Trichlorophenyl)acetic acid
2,3,6-TCA
NSC 41931
HSDB 3434
8SOV3EP1QG
2,3,6-Trichlorophenyl acetic acid
Kyselina 2,3,6-trichlorfenyloctova
EINECS 201-599-3
EPA Pesticide Chemical Code 082601
BRN 2113332
DTXSID2040284
CHEBI:82235
2,3,6-Trichlorphenylessigsaeure [German]
Kyselina 2,3,6-trichlorfenyloctova [Czech]
CHLORFENAC [MI]
CHLORFENAC [ISO]
CHLORFENAC [HSDB]
NSC-41931
DTXCID0020284
4-09-00-01681 (Beilstein Handbook Reference)
UNII-8SOV3EP1QG
SCHEMBL55504
2,6-Trichlorphenylessigsaeure
WLN: QV1R BG CG FG
2,3,6Trichlorphenylessigsaeure
CHEMBL1895774
2,3,6Trichlorobenzeneacetic acid
(2,6-Trichlorophenyl)acetic acid
2,3,6-Trichlorophenylacetic-acid
2,3,6Trichlorophenyl acetic acid
Kyselina 2,3,6trichlorfenyloctova
Benzeneacetic acid,3,6-trichloro-
2,3,6TCA
Acetic acid,3,6-trichlorophenyl)-
NSC41931
Benzeneacetic acid, 2,3,6trichloro
Tox21_301910
(2,3,6-trichlorophenyl)ethanoic acid
Acetic acid, (2,3,6trichlorophenyl)
AKOS015902753
CS-W020959
CAS-85-34-7
NCGC00166150-01
NCGC00255534-01
DB-056865
NS00022841
Chlorfenac, PESTANAL(R), analytical standard
C19114
Q27155828
201-599-3