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ABT-199

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Identification
Molecular formula
C7H10BNO3S
CAS number
1615550-55-8
IUPAC name
[[2-(2-thienyl)acetyl]amino]methylboronic acid
State
State

At room temperature, [[2-(2-thienyl)acetyl]amino]methylboronic acid is a solid. It is stable under standard laboratory conditions, exhibiting typical solid-state characteristics such as resistance to compression and a defined crystalline structure.

Melting point (Celsius)
156.00
Melting point (Kelvin)
429.15
Boiling point (Celsius)
230.00
Boiling point (Kelvin)
503.15
General information
Molecular weight
182.03g/mol
Molar mass
182.0000g/mol
Density
1.3723g/cm3
Appearence

[[2-(2-thienyl)acetyl]amino]methylboronic acid typically appears as a white to off-white powder. The compound's solid state is characterized by fine crystalline particles, which may appear slightly beige or light yellow depending on purity and environmental conditions such as humidity and light exposure.

Comment on solubility

Solubility of [2-(2-thienyl)acetyl]amino]methylboronic acid

The solubility of [2-(2-thienyl)acetyl]amino]methylboronic acid (C7H10BNO3S) displays interesting characteristics due to its unique molecular structure. This compound contains both hydrophilic and hydrophobic components, which can significantly influence its solubility in various solvents.

Factors Affecting Solubility

Key factors that influence the solubility of this compound include:

  • Functional Groups: The presence of the boronic acid group can enhance solubility in polar solvents, particularly in water.
  • Molecular Interactions: The thienyl component introduces aromatic characteristics that may limit solubility in non-polar solvents.
  • pH Sensitivity: Variations in pH can lead to changes in the ionization state of the boronic acid, further affecting solubility.

Solvent Compatibility

This compound demonstrates varying solubility in different solvents:

  • Highly Soluble: Water, due to the polar nature of the boronic acid.
  • Moderately Soluble: Alcohols, benefiting from their ability to engage in hydrogen bonding.
  • Poorly Soluble: Non-polar solvents like hexane, which cannot interact effectively with the molecule.

In summary, understanding the solubility properties of [2-(2-thienyl)acetyl]amino]methylboronic acid not only highlights its potential applications but also indicates the necessity for careful selection of solvents in experimental settings.

Interesting facts

[2-(2-thienyl)acetyl]amino}methylboronic acid

[2-(2-thienyl)acetyl]amino}methylboronic acid is a fascinating compound that showcases the unique interplay between boron chemistry and organic synthesis. Here are some interesting facts about this intriguing molecule:

  • Versatile Reactivity: The boronic acid functional group is well-known for its ability to participate in cross-coupling reactions, particularly in the formation of carbon-carbon bonds. This makes it a valuable building block in the synthesis of complex organic molecules.
  • Medicinal Potential: Compounds containing boron, like this one, have attracted attention in medicinal chemistry. They may exhibit properties that can be optimized for therapeutic applications, including the development of potential antidiabetic agents.
  • Thienyl Influence: The presence of the thienyl group introduces interesting electronic characteristics, which can affect the compound's reactivity and interactions. This aromatic ring can enhance the stability of the molecule and may even contribute to improved biological activity.
  • Green Chemistry: The application of boronic acids in green chemistry highlights their usefulness in synthesizing compounds with a reduced environmental footprint, as many reactions can be performed under mild conditions and often yield minimal waste.

In the world of chemical research, compounds like [2-(2-thienyl)acetyl]amino}methylboronic acid stand out for their potential applications across diverse fields, from organic synthesis to medicinal chemistry. As researchers continue to explore and innovate, the full array of properties and uses for this compound remains an exciting topic of study.

Synonyms
448211-54-9
N-2-THIOPHEN-2-YL-ACETAMIDE BORONIC ACID
((2-(Thiophen-2-yl)acetamido)methyl)boronic acid
8KWZ834LZM
CHEMBL320049
(2-Thiophen-2-ylethanoylamino)methylboronic acid
{[2-(thiophen-2-yl)acetamido]methyl}boronic acid
[(2-thiophen-2-ylacetyl)amino]methylboronic Acid
[[2-(Thiophen-2-yl)acetamido]methyl]boronic acid
B-(((2-(2-Thienyl)acetyl)amino)methyl)boronic acid
B-[[[2-(2-Thienyl)acetyl]amino]methyl]boronic acid
Boronic acid, B-(((2-(2-thienyl)acetyl)amino)methyl)-
Boronic acid, B-[[[2-(2-thienyl)acetyl]amino]methyl]-
starbld0019223
UNII-8KWZ834LZM
Acylglycineboronic acid, 11
LP04
SCHEMBL12753869
DTXSID80274383
BDBM50115621
DB02094
NS00073521
(2-(thiophen-2-yl)acetamido)methylboronic acid
[[2-(2-thienyl)acetyl]amino]methylboronic acid
{[(thiophen-2-ylacetyl)amino]methyl}boronic acid
N-dihydroxyBoranylmethyl-2-thiophen-2-yl-acetamide
Q27093166