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Tolfenamic acid

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Identification
Molecular formula
C14H12NO4S
CAS number
13710-19-5
IUPAC name
2-[2-phenyl-N-(p-tolylsulfonyl)anilino]acetic acid
State
State

At room temperature, tofenamic acid is a solid.

Melting point (Celsius)
210.00
Melting point (Kelvin)
483.15
Boiling point (Celsius)
372.10
Boiling point (Kelvin)
645.25
General information
Molecular weight
261.31g/mol
Molar mass
261.2870g/mol
Density
1.3385g/cm3
Appearence

Tolfenamic acid is an off-white crystalline powder. It is practically insoluble in water but can dissolve in organic solvents such as ethanol and acetone.

Comment on solubility

Solubility of 2-[2-phenyl-N-(p-tolylsulfonyl)anilino]acetic acid

The solubility of 2-[2-phenyl-N-(p-tolylsulfonyl)anilino]acetic acid (C14H12NO4S) can be influenced by various factors, including its structure and the presence of functional groups. Understanding solubility is crucial for several applications, including drug formulation and environmental impact assessments.

Key factors affecting solubility:

  • Polarity: The presence of polar functional groups such as the sulfonyl (-SO2H) and carboxylic acid (-COOH) groups greatly enhances the solubility in polar solvents like water.
  • Hydrogen bonding: The ability to form hydrogen bonds with water molecules also contributes to the overall solubility. Compounds that can act as both hydrogen bond donors and acceptors are typically more soluble.
  • Hydrophobic interactions: The phenyl and tolyl groups in the compound may introduce hydrophobic character, potentially lowering solubility in polar solvents.

Generally, salts of acids are often more soluble than their neutral counterparts. Therefore, the solubility of this compound in aqueous solutions can be enhanced by adjusting the pH, which can potentially ionize the carboxylic acid group, leading to increased solubility due to the formation of charged species.

In summary, while the compound exhibits both polar and non-polar characteristics, its solubility profile is contingent upon interactions with solvents and the surrounding environment, making it essential to consider these factors in practical applications.

Interesting facts

Interesting Facts about 2-[2-phenyl-N-(p-tolylsulfonyl)anilino]acetic acid

This compound, often associated with the realm of medicinal chemistry, demonstrates intriguing properties that make it noteworthy. Here are several points of interest:

  • Pharmaceutical Applications: This compound is considered for its potential use in pharmaceuticals due to its structural characteristics, which can influence biological activity.
  • Functional Groups: The presence of both an acetic acid moiety and a sulfonamide unit allows for unique interactions in biological systems, enabling researchers to explore various mechanisms of action.
  • Structurally Diverse: The combination of phenyl and p-tolylsulfonyl groups adds to its structural complexity, making it a subject of study for compound interactions and reactivity.
  • Scientific Research: As a topic of ongoing research, scientists are investigating its effects and potential benefits in treating specific health conditions.
  • Reactivity: Various reaction pathways can be explored based on its functional groups, leading to the development of derivatives that may enhance efficacy or reduce side effects.

As you delve into the world of organic compounds, remember that the intricate design of each molecule can unlock new discoveries in science and medicine. As noted by many researchers, “The best way to predict the future is to invent it,” embodying the spirit of innovation in chemical exploration.

Synonyms
NSC114943
AKOS024419236
NSC-114943
(BIPHENYL-2-YL-(TOLUENE-4-SULFONYL)-AMINO)-ACETIC ACID