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2-(2-hydroxyphenyl)benzimidazole-5-carboxamidine

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Identification
Molecular formula
C14H11N3O
CAS number
490-00-0
IUPAC name
2-(2-hydroxyphenyl)-3H-benzimidazole-5-carboxamidine
State
State

This compound is a solid at room temperature, characterized by its crystalline form. It is not volatile under standard conditions, remaining stable as a powder unless subjected to high temperatures or reactive environments.

Melting point (Celsius)
318.00
Melting point (Kelvin)
591.00
Boiling point (Celsius)
502.00
Boiling point (Kelvin)
775.00
General information
Molecular weight
239.26g/mol
Molar mass
239.2610g/mol
Density
1.3200g/cm3
Appearence

The compound 2-(2-hydroxyphenyl)benzimidazole-5-carboxamidine typically appears as an off-white to yellow crystalline powder. The exact shade can vary slightly depending on the purity and the presence of any impurities. It is generally stable under normal conditions.

Comment on solubility

Solubility of 2-(2-hydroxyphenyl)-3H-benzimidazole-5-carboxamidine (C14H11N3O)

The solubility of 2-(2-hydroxyphenyl)-3H-benzimidazole-5-carboxamidine can provide insight into its potential applications and interactions in various environments. Understanding its solubility is crucial for determining its behavior in biological systems and its utility in pharmaceutical formulations. Here are several key points to consider:

  • Polar vs. Non-Polar: The presence of both polar (such as the -OH group) and non-polar components in the molecule suggests that it may exhibit a degree of solubility in polar solvents like water, as well as in organic solvents.
  • pH Influence: The solubility could vary significantly with the pH of the solution due to the carboxamidine functional group, which can be protonated or deprotonated depending on the environmental conditions.
  • Hydrogen Bonding: The potential for hydrogen bond formation, particularly with water molecules, might increase the solubility of this compound in aqueous solutions.
  • Complexation: This compound could potentially form complexes with metal ions or other solubilizing agents, enhancing its overall solubility.

In conclusion, while initial predictions regarding solubility highlight the possibility of moderate solubility in a variety of solvents, empirical testing under controlled conditions is essential to determine the exact solubility profile of 2-(2-hydroxyphenyl)-3H-benzimidazole-5-carboxamidine. Such data would be valuable for its prospective applications in research and industry.

Interesting facts

Interesting Facts about 2-(2-hydroxyphenyl)-3H-benzimidazole-5-carboxamidine

2-(2-hydroxyphenyl)-3H-benzimidazole-5-carboxamidine is a fascinating compound with a multitude of applications in various scientific fields. Here are some insightful aspects about this intriguing chemical:

  • Biological Activity: This compound has been studied for its potential biological properties, including antimicrobial and anticancer activities. Its structure allows for interactions with biological targets, making it a subject of interest in medicinal chemistry.
  • Aromatic Features: With a benzimidazole core structure, this compound exhibits unique aromatic characteristics that contribute to its stability and reactivity. Aromatic compounds are essential in organic chemistry due to their resonance stability.
  • Hydroxyl Groups: The presence of hydroxyl groups in its structure enhances its hydrogen bonding capabilities, leading to increased solubility in polar solvents, which is vital for biological activity and efficacy in drug formulations.
  • Complex Interactions: Researchers are exploring the compound's ability to form complexes with metal ions, which can lead to the development of novel therapeutic agents or catalysts in organic synthesis.
  • Research Frontiers: The compound is being investigated in various research initiatives for its potential use as a probe in biological studies or as a lead compound for new drug development.

As highlighted by leading researchers in the field, "The unique structural features of 2-(2-hydroxyphenyl)-3H-benzimidazole-5-carboxamidine offer promising avenues for enhanced biological activities and drug development." This compound exemplifies how intricate designs in chemistry can lead to significant advancements in science and medicine.

Synonyms
CRA_1144
CHEMBL433501
220955-03-3
2-{5-[AMINO(IMINIO)METHYL]-1H-BENZIMIDAZOL-2-YL}BENZENOLATE
AC1OARPH
2-(5-(amino(iminiumyl)methyl)-1H-1,3-benzodiazol-2-yl)benzen-1-olate
2-{5-[amino(iminiumyl)methyl]-1H-1,3-benzodiazol-2-yl}benzen-1-olate
1ghw
1gi1
1gi4
1gi8
1o2s
SCHEMBL4315225
DTXSID70425524
1p57
BDBM50100897
DB03643
NS00070160
2-[2-hydroxyphenyl]-1h-benzimidazole-5-carboxamidine
Q27094562
2-{5-[amino(iminio)methyl]-1H-benzimidazol-2-yl}phenolate