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Aspirin

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Identification
Molecular formula
C9H8O4
CAS number
50-78-2
IUPAC name
2-(2-hydroxybenzoyl)oxybenzoic acid
State
State

Aspirin is generally a solid at room temperature. It is usually available in a fine powder form used for manufacturing tablets.

Melting point (Celsius)
135.00
Melting point (Kelvin)
408.00
Boiling point (Celsius)
140.00
Boiling point (Kelvin)
413.00
General information
Molecular weight
180.16g/mol
Molar mass
180.1570g/mol
Density
1.4000g/cm3
Appearence

Aspirin typically appears as a white, crystalline solid. It is odorless and has a slight acidic taste. The crystals are usually in the form of small, needle-like or tabular structures.

Comment on solubility

Solubility of 2-(2-hydroxybenzoyl)oxybenzoic acid

2-(2-hydroxybenzoyl)oxybenzoic acid, with the chemical formula C9H8O4, exhibits some noteworthy solubility characteristics that are important to understand for its potential applications. Solubility in various solvents is dictated by the compound's molecular structure, which influences its interactions with surrounding solvents.

Solubility Characteristics:

  • Polar Solvents: This compound is generally soluble in polar solvents such as methanol, ethanol, and water to some extent, primarily due to the presence of hydroxyl (-OH) groups that can form hydrogen bonds.
  • Non-Polar Solvents: In contrast, its solubility in non-polar solvents like hexane or benzene is limited, as the structural features of the molecule resist the necessary interactions to dissolve.
  • Temperature Effects: The solubility can also increase with an increase in temperature, which often enhances the solvation process for many organic compounds.

It is essential to note that the overall solubility of 2-(2-hydroxybenzoyl)oxybenzoic acid can be influenced by factors such as pH and the presence of other ions in solution. Thus, solubility testing in various conditions is crucial for applications in pharmaceuticals and chemical formulations.

In conclusion, understanding the solubility of 2-(2-hydroxybenzoyl)oxybenzoic acid can significantly impact its utility and effectiveness in different environments. As stated in many chemical studies, "the solubility of a compound is a gateway to its reactivity and practical applications."

Interesting facts

Interesting Facts about 2-(2-hydroxybenzoyl)oxybenzoic acid

2-(2-hydroxybenzoyl)oxybenzoic acid, often referred to as a type of salicylic acid derivative, holds significant interest in various fields, especially in pharmaceuticals and cosmetics. Here are some fascinating points regarding this compound:

  • Dual Functionality: This compound exhibits characteristics of both an acid and a phenolic compound, making it versatile for different applications.
  • Skin Permeation: Due to its unique structure, it is known for its ability to penetrate the skin effectively, which is particularly valuable in dermatological treatments.
  • Anti-inflammatory Properties: It has been studied for its role in reducing inflammation, which is beneficial in treating conditions such as acne and psoriasis.
  • Antioxidant Activity: This compound also demonstrates notable antioxidant properties, effectively combating oxidative stress and protecting the skin from damage.
  • Cosmetic Applications: As an ingredient in skincare products, it aids in exfoliation and the promotion of cell turnover, contributing to smoother skin texture.

Researchers have dubbed it a “multi-functional agent” because of its numerous beneficial properties. Its intriguing chemical structure facilitates a range of interactions at the cellular level, which continues to be an area of active study.

In summary, 2-(2-hydroxybenzoyl)oxybenzoic acid is a remarkable compound that showcases the intersection of organic chemistry and practical applications in health and beauty. Its utility in various formulations underscores the importance of continual research in the field of chemistry.

Synonyms
Salsalate
552-94-3
sasapyrine
Salicylsalicylic acid
Disalicylic acid
2-Carboxyphenyl salicylate
Disalcid
Sasapyrinum
Sasapirin
Sasapyrin
Diacesal
Diplosal
Disalyl
Nobacid
Salical
Salicyloylsalicylic acid
Saloxium
Salysal
Salina
o-Salicylsalicylic acid
Sal Ester Sal
Disalicylsaeure
Salsalato
2-(2-hydroxybenzoyl)oxybenzoic acid
Salicylic acid, bimolecular ester
Salicylic acid, salicylate
Salsalatum
Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester
NSC-49171
O-Salicylcylsalicylsaeure
Salflex
Salsalatum [INN-Latin]
2-((2-Hydroxybenzoyl)oxy)benzoic acid
Salicyloxysalicylic acid
Salsalato [INN-Spanish]
Disalicyclic acid
EINECS 209-027-4
UNII-V9MO595C9I
MFCD00020252
NSC 49171
Sasapyrine (JAN)
BRN 2590908
CHEBI:9014
V9MO595C9I
Salsalate (Standard)
Salicylic acid bimolecular ester
DTXSID1023572
2-Hydroxybenzoic acid 2-carboxyphenyl ester
NSC49171
Salicylsalicylic acid;Disalicylic acid
DTXCID203572
Salsalate [USAN:USP:INN:BAN]
2-[(2-Hydroxybenzoyl)oxy]benzoic acid
NCGC00096014-01
Salsalatum (INN-Latin)
SASAPYRINE [JAN]
Salsalato (INN-Spanish)
SALSALATE (MART.)
SALSALATE [MART.]
SALSALATE (USP-RS)
SALSALATE [USP-RS]
SALSALATE (USP IMPURITY)
SALSALATE [USP IMPURITY]
SALSALATE (USP MONOGRAPH)
SALSALATE [USP MONOGRAPH]
Salsalate (USAN:USP:INN:BAN)
2-[(2-Hydroxybenzoyl)oxy]benzoic Acid (Salicylsalicylic Acid)
Mono-gesic
O-Salicyloylsalicylic Acid
Disalcid (TN)
CAS-552-94-3
Salsalate (USP/INN)
ACETYLSALICYLIC ACID IMPURITY E (EP IMPURITY)
ACETYLSALICYLIC ACID IMPURITY E [EP IMPURITY]
2-Salicyloyloxybenzoic Acid
Disalgesic
Disalicylsaure
SalsalateRx
Sasapyrine?
Salicylic acid salicylate;2-Hydroxybenzoic acid 2-carboxyphenyl ester
Aspirin Impurity E
2-(2-hydroxybenzoyloxy)benzoic acid
carboxyphenyl salicylate
O-Salicylcylsalicylsaure
Spectrum_001998
SALSALATE [INN]
SALSALATE [MI]
SALSALATE [USAN]
Spectrum2_000693
Spectrum3_000173
Spectrum4_000940
Spectrum5_000670
SALSALATE [VANDF]
SALSALATE [WHO-DD]
2-{[(2-hydroxyphenyl)carbonyl]oxy}benzoic acid
SCHEMBL15562
BSPBio_001665
KBioGR_001500
KBioSS_002572
SPECTRUM200331
Salsalate - Bio-X trade mark
SPBio_000845
CHEMBL154111
Salsalate, >=98% (HPLC)
BDBM85244
HY-B1245R
KBio2_002563
KBio2_005131
KBio2_007699
KBio3_001165
N02BA06
HMS2091A05
HMS3652P07
HMS3885J09
Pharmakon1600-00200331
HY-B1245
NSC_5161
Benzoic acid, 2-carboxyphenyl ester
Tox21_111548
CCG-39652
NSC755823
s4188
Salicylic Acid 2-Carboxyphenyl Ester
AKOS003368478
Tox21_111548_1
CS-4891
DB01399
FS27786
NSC-755823
NCGC00096014-02
NCGC00096014-03
AC-18298
AS-12645
BS300124
CAS_552-94-3
2-[(2-Hydroxybenzoyl)oxy]benzoic acid #
SBI-0206687.P002
DB-020760
CS-0694787
NS00009927
SW219189-1
2-[(2-hydroxyphenyl)carbonyloxy]benzoic acid
C75590
D00428
AB01563259_01
AB01563259_02
SR-05000001536
CARBASALATE CALCIUM IMPURITY D [EP IMPURITY]
Q1320691
SR-05000001536-1
BRD-K48892307-001-04-1
BRD-K48892307-001-05-8
DL-LYSINE ACETYLSALICYLATE IMPURITY M [EP IMPURITY]
Salsalate, United States Pharmacopeia (USP) Reference Standard
209-027-4
Salsalate (Aspirin Impurity E), Pharmaceutical Secondary Standard; Certified Reference Material