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Bendroflumethiazide

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Identification
Molecular formula
C15H13ClF3N3O4S2
CAS number
73-48-3
IUPAC name
2-[2-(hydroxyamino)-2-oxo-ethyl]-N-[1-[(4-methoxyphenyl)methyl]-2-(methylamino)-2-oxo-ethyl]-4-methyl-pentanamide
State
State

At room temperature, Bendroflumethiazide is found in a solid state as a crystalline powder.

Melting point (Celsius)
234.60
Melting point (Kelvin)
507.60
Boiling point (Celsius)
295.00
Boiling point (Kelvin)
568.15
General information
Molecular weight
421.44g/mol
Molar mass
421.4430g/mol
Density
1.3000g/cm3
Appearence

Bendroflumethiazide appears as a white or almost white powder that is practically insoluble in water, freely soluble in ethanol, and soluble in acetone. It is often used in powdered form in pharmaceutical preparations.

Comment on solubility

Solubility of 2-[2-(hydroxyamino)-2-oxo-ethyl]-N-[1-[(4-methoxyphenyl)methyl]-2-(methylamino)-2-oxo-ethyl]-4-methyl-pentanamide (C15H13ClF3N3O4S2)

When considering the solubility of the compound 2-[2-(hydroxyamino)-2-oxo-ethyl]-N-[1-[(4-methoxyphenyl)methyl]-2-(methylamino)-2-oxo-ethyl]-4-methyl-pentanamide, several factors come into play:

  • Polarity: This compound contains multiple functional groups, such as hydroxyl (-OH) and amino (-NH2) groups, which increase its polarity. Generally, polar substances tend to be soluble in polar solvents like water.
  • Hydrogen Bonding: The presence of hydroxyl and amino groups allows for significant hydrogen bonding with solvents, further promoting solubility in aqueous solutions.
  • Alkyl Chain Influence: The 4-methyl-pentanamide section introduces some hydrophobic character to the molecule, which may limit solubility in strictly polar solvents.
  • Organic Solvents: While this compound may exhibit good solubility in polar solvents, it is also likely soluble to a certain extent in organic solvents like ethanol and methanol, due to its mixed polarity.

In conclusion, the overall solubility of this compound can be described as:

  1. Moderate to good solubility in polar solvents, primarily due to polar functional groups.
  2. Varied solubility in organic solvents, influenced by its hydrophobic regions.

As always, conducting empirical tests in the specific solvent of interest is recommended to ascertain precise solubility values.

Interesting facts

Interesting Facts about 2-[2-(hydroxyamino)-2-oxo-ethyl]-N-[1-[(4-methoxyphenyl)methyl]-2-(methylamino)-2-oxo-ethyl]-4-methyl-pentanamide

This compound, often referred to in scientific literature as a complex organic molecule, showcases fascinating characteristics that highlight the intersection of chemistry and pharmacology. Here are some key points of interest:

  • Pharmaceutical Potential: The structure suggests that this compound could possess valuable pharmacological properties, possibly functioning as an effective drug candidate due to its unique arrangement of functional groups.
  • Functional Diversity: The presence of various functional groups, including hydroxyamino, amino, and methoxy moieties, suggests a capacity for diverse chemical reactivity and interaction with biological targets.
  • Structure-Activity Relationship: Understanding how structural variations can influence biological activity is crucial in medicinal chemistry. This compound serves as an excellent example of how small changes can lead to significant differences in efficacy.
  • Design and Synthesis: The synthesis of such a complex compound requires innovative approaches. This includes advanced methods such as multi-step organic synthesis and potentially the use of green chemistry principles to enhance sustainability.
  • Potential Applications: With its intricate structure, this compound could be investigated for applications beyond pharmaceuticals, such as in materials science or catalysis, where unique molecular properties are advantageous.

In conclusion, 2-[2-(hydroxyamino)-2-oxo-ethyl]-N-[1-[(4-methoxyphenyl)methyl]-2-(methylamino)-2-oxo-ethyl]-4-methyl-pentanamide represents a highly intriguing class of compounds. As researchers continue to explore its functionalities and potential applications, it further emphasizes the importance of understanding complex organic compounds in the broader field of chemistry.

Synonyms
SC 44463
CHEMBL3828219
BDBM50187465